Diffusion-weighted MR imaging including bi-exponential fitting for the detection of recurrent or residual tumour after (chemo)radiotherapy for laryngeal and hypopharyngeal cancers

Vogel, Dechen W. Tshering; Zbaeren, Peter; Geretschlaeger, Andreas; Vermathen, Peter; Keyzer, Frederik De; Thoeny, Harriet C.

doi:10.1007/s00330-012-2596-x

Cited by 76 publications

(77 citation statements)

References 20 publications

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“…6–10 Although morphological MRI sequences have a limited performance regarding the detection of nodal metastases, 63 DW MRI with ADC measurements allows detection of subcentimetre metastatic neck nodes. 8 Nevertheless, DW MRI cannot reliably depict nodal metastases <4 mm.…”

Section: Current Evidence About Mri In Hnsccmentioning

confidence: 99%

“…10 However, no data are currently available on the value of DW MRI for the staging of recurrent HNSCC (restaging), in particular, as recent reports have suggested that MRI and CT may grossly underestimate the extent of submucosal tumour spread leading to inadequate treatment in many cases. 65,66 Underestimation of submucosal spread in recurrent HNSCC is caused by post-therapeutic inflammation with fibrosis on the one hand and by the fact that recurrent tumours show a different pattern of submucosal spread on the other hand.…”

Section: Current Evidence About Mri In Hnsccmentioning

confidence: 99%

“…1,2 Clinical MRI has evolved towards higher field strengths (3 T), faster sequences, whole-body imaging, as well as functional imaging capabilities, including DW MRI and perfusion imaging. 4–10 Despite all these technical advances, considerable expertise is required for the diagnostic interpretation of head and neck imaging studies because of the complex regional anatomy, the variable appearance of primary and recurrent tumours and functional phenomena mimicking disease.…”

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confidence: 99%

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Imaging in head and neck squamous cell carcinoma: the potential role of PET/MRI

Becker

Zaidi²

2014

BJR

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In head and neck oncology, the information provided by positron emission tomography (PET)/CT and MRI is often complementary because both the methods are based on different biophysical foundations. Therefore, combining diagnostic information from both modalities can provide additional diagnostic gain. Debates about integrated PET/MRI systems have become fashionable during the past few years, since the introduction and wide adoption of software-based multimodality image registration and fusion and the hardware implementation of integrated hybrid PET/MRI systems in pre-clinical and clinical settings. However, combining PET with MRI has proven to be technically and clinically more challenging than initially expected and, as such, research into the potential clinical role of PET/MRI in comparison with PET/CT, diffusion-weighted MRI (DW MRI) or the combination thereof is still ongoing. This review focuses on the clinical applications of PET/MRI in head and neck squamous cell carcinoma (HNSCC). We first discuss current evidence about the use of combined PET/CT and DW MRI, and, then, we explain the rationale and principles of PET/MR image fusion before summarizing the state-of-the-art knowledge regarding the diagnostic performance of PET/MRI in HNSCC. Feasibility and quantification issues, diagnostic pitfalls and challenges in clinical settings as well as ongoing research and potential future applications are also discussed.

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Section: Current Evidence About Mri In Hnsccmentioning

confidence: 99%

Section: Current Evidence About Mri In Hnsccmentioning

confidence: 99%

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confidence: 99%

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Imaging in head and neck squamous cell carcinoma: the potential role of PET/MRI

Becker

Zaidi²

2014

BJR

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“…Requiring such a long disease-free period creates a selection bias favoring patients without tumor recurrence. We considered another six studies to be at high risk of bias because a non-random selection was carried out as patients with at high risk for recurrence or with a suspicion of recurrence were included only [18]B,[21,23,27,28,31]. Moreover, in one study it was only stated that they included nasopharyngeal carcinomas without explicitly mentioning the inclusion of squamous cell carcinomas, providing an additional argument to classify this study as high risk [31].…”

Section: Resultsmentioning

confidence: 99%

“…In the index test domain a total of nine studies were considered to be of unclear risk as it was not described whether the results were interpreted without the knowledge of the reference standard [16,18]A,[18]B,[19,21,22,24,25,28,29]. The other seven studies were classified as low risk [17,19,20,23,26,27,31].…”

Section: Resultsmentioning

confidence: 99%

Diagnostic accuracy of magnetic resonance imaging techniques for treatment response evaluation in patients with head and neck tumors, a systematic review and meta-analysis

et al. 2017

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BackgroundNovel advanced MRI techniques are investigated in patients treated for head and neck tumors as conventional anatomical MRI is unreliable to differentiate tumor from treatment related imaging changes.PurposeAs the diagnostic accuracy of MRI techniques to detect tumor residual or recurrence during or after treatment is variable reported in the literature, we performed a systematic meta-analysis.Data sourcesPubmed, EMBASE and Web of Science were searched from their first record to September 23th 2014.Study selectionStudies reporting diagnostic accuracy of anatomical, ADC, perfusion or spectroscopy to identify tumor response confirmed by histology or follow-up in treated patients for head and neck tumors were selected by two authors independently.Data analysisTwo authors independently performed data extraction including true positives, false positives, true negatives, false negatives and general study characteristics. Meta-analysis was performed using bivariate random effect models when ≥5 studies per test were included.Data synthesisWe identified 16 relevant studies with anatomical MRI and ADC. No perfusion or spectroscopy studies were identified. Pooled analysis of anatomical MRI of the primary site (11 studies, N = 854) displayed a sensitivity of 84% (95%CI 72–92) and specificity of 82% (71–89). ADC of the primary site (6 studies, N = 287) showed a pooled sensitivity of 89% (74–96) and specificity of 86% (69–94).LimitationsMain limitation are the low, but comparable quality of the included studies and the variability between the studies.ConclusionsThe higher diagnostic accuracy of ADC values over anatomical MRI for the primary tumor location emphases the relevance to include DWI with ADC for response evaluation of treated head and neck tumor patients.

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