Diffusional Anisotropy in Cerebral White Matter in Patients with Dementia.

Hanyu, Haruo; Iwamoto, Teruyo; Takasaki, Masaya; Shindo, Hiroaki; Kakizaki, Dai; K, Abe

doi:10.3143/geriatrics.33.761

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found diminished anisotropy in AD patients despite avoiding WMH in ROI placement and correcting for global and focal measures of WMH severity. In the only prior studies of DWI in AD that we are aware of, Hanyu et al [21,22] also found reduced diffusional anisotropy in the white matter of patients with AD. Although they did not attempt to correct for WMH, a subset of AD patients without periventricular hyperintensities had diminished anisotropic ratios compared to the control group.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Diffusion-Weighted Magnetic Resonance Imaging in Alzheimer’s Disease

Sandson

Félician

Edelman

et al. 1999

Dement Geriatr Cogn Disord

101

View full text Add to dashboard Cite

Diffusion-weighted imaging (DWI) is a powerful new magnetic resonance imaging technique for evaluating tissue pathophysiology in vivo. We performed DWI in three orthogonal spatial directions in 10 patients with mild to moderate Alzheimer’s disease (AD) and 11 control subjects. Average apparent diffusion coefficients (ADCavg) were calculated for gray matter regions, and anisotropy indexes were calculated for white matter regions. Global measures of atrophy and white matter hyperintensities (WMH) were obtained on T₂-weighted images to control for their potential confounding effects on ADCavg and anisotropy. The measures of atrophy and WMH differed between the groups and were used as covariates in the subsequent statistical analyses. Patients with AD demonstrated diminished anisotropy in the posterior white matter (p < 0.0001) and increased ADCavg in the hippocampus (p < 0.05) when compared to the control group. Diffusion measures did not correlate with the severity of dementia. DWI provides a unique, quantitative parameter that may be sensitive to the pathophysiological and/or microstructural abnormalities that occur in AD.

show abstract

Section: Discussionmentioning

confidence: 99%

“…ADCavg is diminished in the acute stage of ischemic stroke, which is thought to be related to intracellular water accumulation caused by rapid failure of energy metabolism [19,20]. There have been very few prior studies of DWI in neurodegenerative conditions [21,22].…”

Section: Discussionmentioning

confidence: 99%

Diffusion-Weighted Magnetic Resonance Imaging in Alzheimer’s Disease

Sandson

Félician

Edelman

et al. 1999

Dement Geriatr Cogn Disord

101

View full text Add to dashboard Cite

show abstract

“…DW-MRI is now commonly used to diagnose and evaluate ischemic stroke (1)(2)(3)(4)(5) and is also being applied in many other clinical areas (6)(7)(8)(9)(10)(11). The most common applications of DW-MRI use single-shot echo-planar imaging (SSEPI) methods.…”

mentioning

confidence: 99%

High-resolution diffusion imaging with DIFRAD-FSE (Diffusion-Weighted Radial Acquisition of Data With Fast Spin-Echo) MRI

et al. 1999

View full text Add to dashboard Cite

A novel MRI method, DIFRAD-FSE (diffusion-weighted radial acquisition of data with fast spin-echo), is demonstrated that enables rapid, high-resolution multi-shot diffusion-weighted MRI without significant artifacts due to motion. Following a diffusion-weighting spin-echo preparation period, multiple radial lines of Fourier data are acquired using spin-echo refocusing. Images can be reconstructed from the radial data set using a magnitude-only filtered back-projection reconstruction algorithm that removes phase errors due to motion. Results from human brain imaging demonstrate the ability of DIFRAD-FSE to acquire multiple radial lines of Fourier data each TR period without significant artifacts due to relaxation and to produce high-resolution diffusion-weighted MR images without significant artifacts from motion. Magn Reson Med 42:11

show abstract

Diffusional Anisotropy in Cerebral White Matter in Patients with Dementia.

Cited by 2 publications

References 0 publications

Diffusion-Weighted Magnetic Resonance Imaging in Alzheimer’s Disease

Diffusion-Weighted Magnetic Resonance Imaging in Alzheimer’s Disease

High-resolution diffusion imaging with DIFRAD-FSE (Diffusion-Weighted Radial Acquisition of Data With Fast Spin-Echo) MRI

Contact Info

Product

Resources

About