Difructose Anhydride III Enhances Zinc Absorption in vivo: Zinc Gluconate is More Suitable for the Effects of Difructose Anhydride III than Zinc Yeast

Abstract

Summary We examined the effect of difructose anhydride III (DFAIII) on zinc absorption in rats in two experiments. First, we compared the absorption of zinc from zinc gluconate and zinc yeast with or without DFAIII by measuring concentrations in plasma collected from the portal vein after a single oral administration of zinc gluconate or zinc yeast with or without DFAIII. The peak plasma zinc concentration and the incremental area under the curve (IAUC) of plasma zinc 6 h after administration were highest in the zinc gluconate with DFAIII group. Second, we examined the effect of DFAIII on the absorption of zinc with phytic acid. with or without DFAIII. Plasma zinc levels in groups both with and without DFAIII were nearly the same as those at the baseline. Our results showed that DFAIII was better with zinc gluconate than zinc yeast for zinc absorption, and that DFAIII does not alter the inhibitory effects of phytic acid on zinc absorption.