Digalloylresveratrol, a novel resveratrol analog inhibits the growth of human pancreatic cancer cells

Saiko, Philipp; Graser, Geraldine; Giessrigl, Benedikt; Steinmann, Marie-Thérèse; Schuster, Heike; Lackner, Andreas; Grusch, Michael; Krupitza, Georg; Jaeger, Walter; Venkateswarlu, Somepalli; Golakoti, Trimurtulu; Fritzer‐Szekeres, Monika; Szekeres, Thomas

doi:10.1007/s10637-013-0009-x

Cited by 14 publications

(7 citation statements)

References 48 publications

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“…Digalloylresveratrol (DIG) is a recently synthesized compound that combines the effects of gallic acid and resveratrol (ratio 2:1). Treatment of both AsPC‐1 and BxPC‐3 cells with DIG for 48 h led to an arrest in S phase . Exposure of AsPC‐1 cells to DIG resulted in the phosphorylation of ATM at Ser1981; normally, ATM is activated upon DNA damage and, in turn, causes the phosphorylation of Chk2 at the activating Thr68 site.…”

Section: Effects Of Resveratrol On the Proliferation Of Pancreatic Camentioning

confidence: 99%

Resveratrol in the treatment of pancreatic cancer

Xu¹,

Zong²,

Chen³

et al. 2015

Annals of the New York Academy of Sciences

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Pancreatic cancer (PCa), which is now the fourth most frequent cause of cancer-related death, has a median survival of less than 6 months and a 5-year survival rate of <6%. The hallmarks of this cancer include poor outcome, short survival duration, and resistance to therapy. The poor prognosis of PCa is related to its local recurrence, lymph node and liver metastases, and peritoneal dissemination. Recent studies have indicated that resveratrol has cancer-chemopreventive and anticancer activities. In this short review we summarize the chemopreventive and treatment effects of resveratrol in PCa, as follows: resveratrol inhibits the proliferation of pancreatic cancer cells; induces apoptosis and cell cycle arrest; inhibits metastasis and invasion of PCa cells; inhibits the proliferation and viability of PCa stem cells; enhances the chemoradiosensitization of PCa cells; and can affect diabetes mellitus in addition to PCa. On the basis of these data, resveratrol may be considered a potential anticancer agent for the treatment of PCa.

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Section: Effects Of Resveratrol On the Proliferation Of Pancreatic Camentioning

confidence: 99%

Resveratrol in the treatment of pancreatic cancer

Xu¹,

Zong²,

Chen³

et al. 2015

Annals of the New York Academy of Sciences

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“…Multiple cellular targets include the estrogen and androgen receptors (14), Akt/PKB (4), protein kinase C (15,16), ribonucleotide reductase (12,17), mTOR (13,18), and tubulin (19). In addition, 1 was found to be a radiation sensitizer for melanoma (20).…”

Section: Introductionmentioning

confidence: 99%

Anti-tumor properties of cis-resveratrol methylated analogs in metastatic mouse melanoma cells

et al. 2015

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Resveratrol (E-3,5,4’-trihydroxystilbene) is a polyphenol found in red wine that has been shown to have multiple anti-cancer properties. Although cis (Z) and trans (E) isomers of resveratrol occur in nature, the cis form is not biologically active. However, methylation at key positions of the cis form results in more potent anti-cancer properties. This study determined that synthetic cis-polymethoxystilbenes (methylated analogues of cis-resveratrol) inhibited cancer-related phenotypes of metastatic B16 F10 and non-metastatic B16 F1 mouse melanoma cells. In contrast with cis or trans-resveratrol and trans-polymethoxystilbene which were ineffective at 10 μM, cis-polymethoxystilbenes inhibited motility and proliferation of melanoma cells with low micromolar specificity (IC50 <10 μM). Inhibitory effects by cis-polymethoxystilbenes were significantly stronger with B16 F10 cells and were accompanied by decreased expression of β-tubulin and pleckstrin homology domain-interacting protein, a marker of metastatic B16 cells. Thus, cis-polymethoxystilbenes have potential as chemotherapeutic agents for metastatic melanoma.

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“…Resveratrol has also generated considerable interest because of its anti-cancer potential, and consequently, a number of groups have synthesized analogs of resveratrol with an aim to enhance its efficacy [ 147 , 148 , 149 , 150 , 151 , 152 , 153 ] ( Table 3 ). The DMU-212 analog of resveratrol has not just been reported to exhibit enhanced anti-tumor effects, but, interestingly, its mechanism of action has been reported to be distinct from the parent compound, resveratrol [ 154 ].…”

Section: Challenges For Phytochemicals In Cancer Therapy and Emergmentioning

confidence: 99%

Cancer Chemoprevention by Phytochemicals: Nature’s Healing Touch

et al. 2017

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Phytochemicals are an important part of traditional medicine and have been investigated in detail for possible inclusion in modern medicine as well. These compounds often serve as the backbone for the synthesis of novel therapeutic agents. For many years, phytochemicals have demonstrated encouraging activity against various human cancer models in pre-clinical assays. Here, we discuss select phytochemicals—curcumin, epigallocatechin-3-gallate (EGCG), resveratrol, plumbagin and honokiol—in the context of their reported effects on the processes of inflammation and oxidative stress, which play a key role in tumorigenesis. We also discuss the emerging evidence on modulation of tumor microenvironment by these phytochemicals which can possibly define their cancer-specific action. Finally, we provide recent updates on how low bioavailability, a major concern with phytochemicals, is being circumvented and the general efficacy being improved, by synthesis of novel chemical analogs and nanoformulations.

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Digalloylresveratrol, a novel resveratrol analog inhibits the growth of human pancreatic cancer cells

Cited by 14 publications

References 48 publications

Resveratrol in the treatment of pancreatic cancer

Resveratrol in the treatment of pancreatic cancer

Anti-tumor properties of cis-resveratrol methylated analogs in metastatic mouse melanoma cells

Cancer Chemoprevention by Phytochemicals: Nature’s Healing Touch

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