Digestion, Absorption, and Fermentation of Carbohydrates in the Newborn

Kien, C. Lawrence

doi:10.1016/s0095-5108(18)30239-2

Cited by 82 publications

(58 citation statements)

References 118 publications

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“…The microbiota also produces metabolites such as short chain fatty acids (acetate, propionate and butyrate) that result from fermentation (Kien, 1996). As well as a major energy source for epithelial cells, butyrate affects cellular proliferation and differentiation, increases intestinal blood flow, and may also aid in the strengthening of tight junctions (Neu, 2007;Sanderson, 2004).…”

Section: Microbial Barriermentioning

confidence: 99%

“…These may be released from neurons or other cell types and act on receptors located on a variety of cells including smooth muscle and enteric neurons. Factors that affect neuromodulation can also affect smooth muscle contractility and hence affect transit (Kien, 1996). For example, butyrate produced by bacteria stimulates serotonin (5HT) release from enterochromaffin cells (Fukumoto et al, 2003).…”

Section: The Role Of Motility In Intestinal Barrier Functionmentioning

confidence: 99%

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The Role of Intestinal Barrier Function in Early Life in the Development of Colitis

Anderson¹,

Dalziel²,

Gopal³

et al. 2012

Colitis

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Section: Microbial Barriermentioning

confidence: 99%

Section: The Role Of Motility In Intestinal Barrier Functionmentioning

confidence: 99%

The Role of Intestinal Barrier Function in Early Life in the Development of Colitis

Anderson¹,

Dalziel²,

Gopal³

et al. 2012

Colitis

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“…An increase in transit time will result in increased delivery of carbohydrates to the large bowel and consequently greater bacterial fermentation (Kien et al, 1987(Kien et al, , 1989(Kien et al, , 1992(Kien et al, , 1996. The quantitative contribution of the bacterial fermentation products, that is short chain fatty acids, to whole body energy metabolism, remains inconclusive (Kien et al, 1989). Short chain fatty acids produced by bacterial fermentation have been shown to affect whole body glucose metabolism (Thorburn et al, 1993).…”

Section: Type Of Carbohydratementioning

confidence: 99%

Carbohydrate as nutrient in the infant and child: range of acceptable intake

Kalhan

Kılıç

1999

Eur J Clin Nutr

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Carbohydrates are the major source of energy for humans. Following their digestion, almost all ingested carbohydrates are converted to glucose. Glucose is the primary oxidative fuel for the brain. Although few studies have been done in infants and children to de®ne the upper and lower limits of carbohydrate intake, such information may be derived from the published data on glucose metabolism in vivo. The upper and lower limits are determined by the need to provide for total energy expenditure, need for other essential nutrients such as protein and fats, requirements of the glucose dependent tissues such as the brain, and the need to minimize the protein cost of gluconeogenesis and thus irreversible loss of nitrogen. With these considerations, the upper and lower boundaries of carbohydrate intake in relation to age are described.

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“…This condition was worsened by a moderate physical activity. [28][29][30][31][32][33][34] The main features of the patient's metabolic acidosis, resulting from this process, recall the findings of monosaccharide intolerance (normal lactacidemia, normal anion gap, low fecal pH, fecal clinitest +++). This aspect is further confirmed by temporal link between these attacks and an excessive carbohydrates intake, which confirms the role played by monosaccharides in causing these symptoms.…”

Section: Discussionmentioning

confidence: 96%

Clinical case and short review of extreme short bowel syndrome: an update 21 years after

et al. 2016

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Short bowel syndrome refers to the malabsorptive state caused by loss of significant portions of the small intestine, whose clinical framework is characterized by malnutrition, diarrhea, dehydration, weight loss, and low-weight-related symptoms/signs. These clinical conditions seem to be related to the length of resection. Twenty-one years ago we reported the clinical case of an infant, who underwent a massive resection of the loops of the small intestine, of the cecum and of part of the ascending colon, due to intestinal malrotation with volvulus. The residual small intestine measured just 11 cm and consisted of the duodenum and a small part of jejunum, in the absence of the ileocecal valve, configuring the case of a ultra-short bowel syndrome. In this report, we update the case, reporting the patient succeeded to obtain a good weight gain and to conduct a quite normal lifestyle, despite the long-term consequences of such resection.

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Digestion, Absorption, and Fermentation of Carbohydrates in the Newborn

Cited by 82 publications

References 118 publications

The Role of Intestinal Barrier Function in Early Life in the Development of Colitis

The Role of Intestinal Barrier Function in Early Life in the Development of Colitis

Carbohydrate as nutrient in the infant and child: range of acceptable intake

Clinical case and short review of extreme short bowel syndrome: an update 21 years after

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