Digital Medicine – The New Frontier for AI in Healthcare

Ho, Dean; Teo, Gavin

doi:10.1002/adtp.202000015

Cited by 7 publications

(9 citation statements)

References 23 publications

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“…Artificial intelligence (AI) can also be integrated into the functioning of nanoparticle-based dressings [ 278 , 279 ]. AI avails of health benefits by automated learning and proctoring myriads of clinical records for manging wound care decision making with predictive data [ 280 ].…”

Section: Advanced Nanotechnologymentioning

confidence: 99%

Engineered Nanotechnology: An Effective Therapeutic Platform for the Chronic Cutaneous Wound

et al. 2022

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The healing of chronic wound infections, especially cutaneous wounds, involves a complex cascade of events demanding mutual interaction between immunity and other natural host processes. Wound infections are caused by the consortia of microbial species that keep on proliferating and produce various types of virulence factors that cause the development of chronic infections. The mono- or polymicrobial nature of surface wound infections is best characterized by its ability to form biofilm that renders antimicrobial resistance to commonly administered drugs due to poor biofilm matrix permeability. With an increasing incidence of chronic wound biofilm infections, there is an urgent need for non-conventional antimicrobial approaches, such as developing nanomaterials that have intrinsic antimicrobial-antibiofilm properties modulating the biochemical or biophysical parameters in the wound microenvironment in order to cause disruption and removal of biofilms, such as designing nanomaterials as efficient drug-delivery vehicles carrying antibiotics, bioactive compounds, growth factor antioxidants or stem cells reaching the infection sites and having a distinct mechanism of action in comparison to antibiotics—functionalized nanoparticles (NPs) for better incursion through the biofilm matrix. NPs are thought to act by modulating the microbial colonization and biofilm formation in wounds due to their differential particle size, shape, surface charge and composition through alterations in bacterial cell membrane composition, as well as their conductivity, loss of respiratory activity, generation of reactive oxygen species (ROS), nitrosation of cysteines of proteins, lipid peroxidation, DNA unwinding and modulation of metabolic pathways. For the treatment of chronic wounds, extensive research is ongoing to explore a variety of nanoplatforms, including metallic and nonmetallic NPs, nanofibers and self-accumulating nanocarriers. As the use of the magnetic nanoparticle (MNP)-entrenched pre-designed hydrogel sheet (MPS) is found to enhance wound healing, the bio-nanocomposites consisting of bacterial cellulose and magnetic nanoparticles (magnetite) are now successfully used for the healing of chronic wounds. With the objective of precise targeting, some kinds of “intelligent” nanoparticles are constructed to react according to the required environment, which are later incorporated in the dressings, so that the wound can be treated with nano-impregnated dressing material in situ. For the effective healing of skin wounds, high-expressing, transiently modified stem cells, controlled by nano 3D architectures, have been developed to encourage angiogenesis and tissue regeneration. In order to overcome the challenge of time and dose constraints during drug administration, the approach of combinatorial nano therapy is adopted, whereby AI will help to exploit the full potential of nanomedicine to treat chronic wounds.

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Section: Advanced Nanotechnologymentioning

confidence: 99%

Engineered Nanotechnology: An Effective Therapeutic Platform for the Chronic Cutaneous Wound

et al. 2022

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“…The technological significance of our novel tool and others in this space is immaterial if those commissioning and practicing medicine fail to see the relevance of its impact on both the efficiency and effectiveness of clinical care. The growth of software use in the healthcare sector has been driven in part by meeting clinical need but also through the expansion of software providers looking to exploit new markets [68]. Sometimes these tools fail to meet the basic needs of utility and usability required by clinicians and support staff [69] and there has been a previous reluctance to engage end-users in the procurement of healthcare technologies leading to a reluctance to engage with digital solutions [70][71][72][73][74].…”

Section: Winning Hearts and Mindsmentioning

confidence: 99%

Automated conflict resolution for patients with multiple morbidity being treated using more than one set of single condition clinical guidance: A case study

Litchfield

Turner

Filho

et al. 2022

Computers in Biology and Medicine

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“…In the future, nanoparticle-based dressings can also integrate their functionality with artificial intelligence (AI). − In cancer research, AI has been developed based on a convolutional neural network to rapidly identify various tumor cells from normal mammalian cells with 96% accuracy . A novel technology named “quantitative live cell histology” has been reported using AI to identify melanoma cells and predict the spread of melanoma .…”

Section: Challenges and Perspectivesmentioning

confidence: 99%

Intelligent Nanoparticle-Based Dressings for Bacterial Wound Infections

Jiang

Loo

2020

ACS Appl. Bio Mater.

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Conventional wound dressing materials containing free antibiotics for bacterial wound infections are presented with several limitations, that is, lack of controlled and triggered release capabilities, and may often not be adequate to address the complex bacteria microenvironment of such infections. Additionally, the improper usage of antibiotics may also result in the emergence of drug resistant strains. While delivery systems (i.e., nanoparticles) that encapsulate antibiotics may potentially overcome some of these limitations, their therapeutic outcomes are still less than desirable. For example, premature drug release or unintended drug activation may occur, which would greatly reduce treatment efficacy. To address this, responsive nanoparticle-based antimicrobial therapies could be a promising strategy. Such nanoparticles can be functionalized to react to a single stimulus or multi stimulus within the bacteria microenvironment and subsequently elicit a therapeutic response. Such "intelligent" nanoparticles can be designed to respond to the microenvironment, that is, an acidic pH, the presence of specific enzymes, bacterial toxins, etc. or to an external stimulus, for example, light, thermal, etc. These responsive nanoparticles can be further incorporated into wound dressings to better promote wound healing. This review summarizes and highlights the recent progress on such intelligent nanoparticle-based dressings as potential wound dressings for bacteria-infected wounds, along with the current challenges and prospects for these technologies to be successfully translated into the clinic.

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Digital Medicine – The New Frontier for AI in Healthcare

Cited by 7 publications

References 23 publications

Engineered Nanotechnology: An Effective Therapeutic Platform for the Chronic Cutaneous Wound

Engineered Nanotechnology: An Effective Therapeutic Platform for the Chronic Cutaneous Wound

Automated conflict resolution for patients with multiple morbidity being treated using more than one set of single condition clinical guidance: A case study

Intelligent Nanoparticle-Based Dressings for Bacterial Wound Infections

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