The development of innovative potential of the region through the formation of a regional innovation system, in the context of innovative development of the construction complex of the region, is relevant. The article considers the regions of the North-Western Federal district, analyzes the state of innovation activity, which allowed to determine that high innovation activity is inherent in St. Petersburg, as well as some regions of the Arctic zone of the Russian Federation: Murmansk region, Arkhangelsk region and the Republic of Komi. Also, the list of stages, which must be followed in the innovative development of the construction complex of the region, namely: 1) creation of conditions for increasing the intellectual potential of the construction complex within the existing legislation; 2) creation of information specialized data Bank on patents, advanced technologies, inventions, research organizations, scientists; 3) Association and coordination of activities of enterprises of the construction complex for innovative development; 4) saturation of the labor market with highly qualified specialists in the field of construction. In this connection, the article forms a model of the regional innovation system, where the building complex acts as a factor of innovative development. The model reflects in the context of the micro-level, meso-level and macro-level the points that need to be worked out for the development of the construction complex as a driver of the regional innovation system. In accordance with the model, the integral innovative potential of the construction enterprise is determined, subsystems are identified: organizational and institutional mechanisms; investments; the level of scientific and technical development; factors and conditions of the external and internal environment; human resources. In accordance with the subsystems selected targets and built a strategic map of the integrated innovation potential of the construction complex of the region.