Digital Necrosis and Lupus-Like Syndrome Preceeding Ovarian Carcinoma

Chtourou, Maher; Aubin, F.; Savariault, I.; Chabot, Pierre; Manchet, G.; Montcuquet, Ph.; Humbert, P

doi:10.1159/000017912

Cited by 18 publications

(9 citation statements)

References 11 publications

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“…She achieved lasting remission from SLE after 21 years. In the other case, a 54-year-old woman was diagnosed with SLE (lymphopenia, digital necrosis, positive antinuclear antibody, positive anti-dsDNA antibody, positive anticardiolipin antibody) and ovarian adenocarcinoma (17). No involvement of the renal or central nervous systems was seen.…”

Section: Discussionmentioning

confidence: 99%

Systemic Lupus Erythematosus Associated with Ovarian Cancer

et al. 2019

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Systemic lupus erythematosus (SLE) may be associated with various types of malignancy. However, SLE occurring with ovarian cancer seems rare, and reliable therapeutic approaches for such cases have yet to be identified. We herein report a case of SLE with ovarian cancer that was successfully treated with corticosteroid, plasmapheresis and chemotherapy. This case may provide new insights into treatment approaches for SLE with ovarian cancer.

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Section: Discussionmentioning

confidence: 99%

Systemic Lupus Erythematosus Associated with Ovarian Cancer

et al. 2019

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“…An SLE-like syndrome has been described in association with malignancies. A syndrome characterized by non-deforming arthritis, polyserositis, glomerulonephritis and Raynaud's phenomenon, has been related to breast, lung and ovary cancer, as well as leukemias and lymphomas (31,40,(169)(170)(171)(172)(173)(174)(175)(176). Positive ANA and anti-DNA or anti-phospholipid antibodies have been detected (40,57).…”

Section: N Systemic Lupus Erythematosusmentioning

confidence: 99%

Paraneoplastic rheumatic disorders: a narrative review

et al. 2018

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Paraneoplastic syndromes (PS) are a heterogeneous group of diseases related to a neoplasm, indirectly dependent on it. Diagnosis and the treatment are often a challenge for clinicians, not least because the pathogenetic mechanisms are highly complex and not entirely known. Nonetheless, in most cases, PS precede the diagnosis of malignancies, thus their identification is particularly important in addressing physicians’ diagnostic work-up with regard to early cancer diagnosis. Among paraneoplastic syndromes, those of rheumatologic interest represent a large component. In this paper, we review the main rheumatic PS.

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“…Since then, few other cases have been described in literature, in association with different types of primary tumor [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] (Table 1). In the most cases the patients were elderly women with adenocarcinomas of digestive or gynaecologic apparatuses [10,11].…”

Section: Introductionmentioning

confidence: 99%

Acrocyanosis, Digital Ischemia and Acronecrosis as first manifestations of Endometrial Adenocarcinoma: Case Presentation and Literature Review

Spinelli¹,

Miele²,

Russo³

et al. 2016

Int J Gynecol Clin Pract

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The association between digital ischemia and cancer is rarely reported in literature and the exact mechanism of this occurrence has not been completely understood. We report here a case of a 73 yearold woman who presented digital ischemia as first manifestation of endometrial adenocarcinoma. Reporting this rare clinical case and with a brief literature review, we recommend to consider an intensive search for primary and metastatic cancer in all patients who experience a digital ischemia, with the aim to early detect and treat the disease.

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Digital Necrosis and Lupus-Like Syndrome Preceeding Ovarian Carcinoma

Abstract: Since 1967, about 40 cases of digital necrosis associated with neoplasia have been reported. We report a new case of digital necrosis associated with an ovarian carcinoma and with a lupus-like syndrome. Immunologic cross-reactivity to tumoral antigen could explain the lupus-like syndrome.

Cited by 18 publications

References 11 publications

Systemic Lupus Erythematosus Associated with Ovarian Cancer

Systemic Lupus Erythematosus Associated with Ovarian Cancer

Paraneoplastic rheumatic disorders: a narrative review

Acrocyanosis, Digital Ischemia and Acronecrosis as first manifestations of Endometrial Adenocarcinoma: Case Presentation and Literature Review

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