This literature-based chapter addresses the vital issues and challenges of KM in respect of knowledge transfer barriers and mechanisms of Hasnain, Jasimuddin, and Fuller-Love and makes an endeavor to materialize those with TM strategies mainly identified by Whelan and Carcary in the context of the COVID-19 pandemic. The contributions of talent management (TM) and knowledge management (KM) are undisputedly acknowledged by researchers and business organizations. Both TM researchers and KM researchers have hardly addressed the strategies of integrating TM and KM for implementing TM strategies against KM challenges in the context of the COVID-19 pandemic. Positioning and integrating appropriately the TM strategies against KM challenges could derive huge benefits for the organizations during hostilities. The COVID-19 pandemic has made the world environment volatile and complex. Therefore, numerous challenges of KM have emerged demanding TM strategies.