Digital subtraction angiography abnormalities in sudden unilateral profound hearing loss

Psillas, George; Kekes, Georgios; Giavroglou, Konstantinos; Daniilidis, J

doi:10.1080/00016480510029275

Cited by 2 publications

(2 citation statements)

References 24 publications

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“…Recently, many studies have been performed to explore the cause and pathogenesis of SSNHL [11][12][13][14][15]. Thus far, These signals may reflect minor hemorrhage or the increased concentration of protein in the inner ear, which has passed through blood vessels with increased permeability [5].…”

Section: Discussionmentioning

confidence: 99%

A comparison of inner ear imaging features at different time points of sudden sensorineural hearing loss with three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging

Zhu

et al. 2014

Eur Arch Otorhinolaryngol

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It has been reported that about half of patients with sudden sensorineural hearing loss (SSNHL) show high signals in the affected inner ear on three-dimensional, fluid-attenuated inversion recovery magnetic resonance imaging (3D-FLAIR MRI). These signals may reflect minor hemorrhage or an increased concentration of protein in the inner ear, which has passed through blood vessels with increased permeability. Our objective was to compare the positive ratio of the high signal in affected inner ears at different time points to determine the suitable imaging time point for 3D-FLAIR MRI in SSNHL. 3D-FLAIR MRI images were taken at three times, precontrast and approximately 10 min and 4 h after intravenous injection of a single dose of gadodiamide (Gd) (0.1 mmol/kg), in 46 patients with SNHL. We compared the positive findings of the high signals in the inner ear of patients with SNHL as well as the signal intensity ratio (SIR) between the affected cochleae and unaffected cochleae at three time points. The positive ratios of the high signals in the affected inner ear at the time points of precontrast and 10 min and 4 h after the intravenous Gd injection were 26.1, 32.6, and 41.3%, respectively. The high signal intensity ratios of affected inner ears at the three time points were 1.28, 1.31, and 1.48, respectively. The difference between the positive ratios precontrast and at 10 min after the intravenous Gd injection was statistically significant (P = 0.006); the differences between the positive ratios at 4 h after the intravenous Gd injection and precontrast and between the ratios at 4 h and 10 min after the intravenous Gd injection were not statistically significant. The time effects of the median value of SIR were not significant (P = 0.064). We do not recommend 4 h after intravenous Gd injection as a time point to image the inner ear in SNHL. We believe that imaging precontrast and at 10 min after the intravenous Gd injection are suitable time points.

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Section: Discussionmentioning

confidence: 99%

A comparison of inner ear imaging features at different time points of sudden sensorineural hearing loss with three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging

Zhu

et al. 2014

Eur Arch Otorhinolaryngol

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“…Sudden hearing loss is often the first symptom of an underlying autoimmune disease that manifests systemically later (Ottaviani et al, 1999; Cadoni et al, 2002; Garcia‐Berrocal et al, 2003; Agrup, 2008; Amor Dorado et al, 2009; Deroee et al, 2009; Hervier et al, 2010). Also, sudden hearing loss has been correlated with inner ear anomalies of semicircular canal hypoplasia and enlarged internal auditory canals (Sugiura et al, 2005), as well as reduced size of anterior inferior cerebellar arteries that serve the affected inner ear (Psillas et al, 2005). None of these underlying genetic influences are known during treatment and subsequent statistical analyses of steroid efficacy.…”

Section: Misconceptions About Corticosteroid Therapy For Hearing and mentioning

confidence: 99%

Corticosteroid Therapy for Hearing and Balance Disorders

Trune

Canlon

2012

The Anatomical Record

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This review addresses the current status of steroid therapies for hearing and vestibular disorders and how certain misconceptions may be undermining the efficacy in restoring normal ear function, both experimentally and clinically. Specific misconceptions addressed are that steroid therapy is not effective, steroid-responsive hearing loss proves an underlying inflammatory problem in the ear, and steroids only have application to the hearing disorders listed below. Glucocorticoid therapy for hearing and balance disorders has been employed for over 60 years. It is recommended in cases of sudden hearing loss, Meniére’s disease, immune-mediated hearing loss, and any vestibular dysfunction suspected of having an inflammatory etiology. The predominant steroids employed today are dexamethasone, prednisone, prednisolone, and methyl-prednisolone. In spite of years of use, little is known of the steroid responsive mechanisms in the ear that are influenced by glucocorticoid therapy. Furthermore, meta-analyses and clinical study reviews occasionally question whether steroids offer any benefit at all. Foremost in the minds of clinicians is the immune suppression and antiinflammatory functions of steroids because of their efficacy for autoimmune hearing loss. However, glucocorticoids have a strong binding affinity for the mineralocorticoid (aldosterone) and glucocorticoid receptors, both of which are prominent in the ear. Because the auditory and vestibular end organs require tightly regulated endolymph and perilymph fluids, this ion homeostasis role of the mineralocorticoid receptor cannot be overlooked in both normal and pathologic functions of the ear. The function of the glucocorticoid receptor is to provide anti-inflammatory and anti-apoptotic signals by mediating survival factors.

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Digital subtraction angiography abnormalities in sudden unilateral profound hearing loss

Cited by 2 publications

References 24 publications

A comparison of inner ear imaging features at different time points of sudden sensorineural hearing loss with three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging

A comparison of inner ear imaging features at different time points of sudden sensorineural hearing loss with three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging

Corticosteroid Therapy for Hearing and Balance Disorders

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