Digoxin-like immunoreactive substance in pregnancy

Gonzalez, Antonio; Phelps, Stephanie J.; Cochran, Emily B.; Sibai, Baha M.

doi:10.1016/s0002-9378(87)80024-8

Cited by 39 publications

(12 citation statements)

References 12 publications

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“…This conclusion is supported by the finding by Morris et al (1988) that in vivo umbilical venous blood levels are higher than arterial, although others have found no difference between the concentrations in these vessels (Gonzales et al 1987). Placental release into the fetal circulation could account for the levels of DLIS in cord blood being higher than those in maternal blood (Gonzales et al 1987) although relatively high concentrations are found in the adrenals (Shilo et al 1987;Guedeney et aE.…”

Section: Discussionmentioning

confidence: 83%

“…DLIS have also been reported to be present in human placental tissues and umbilical cord blood (Diamandis et al 1985;Gonzales et al 1987;Morris et al 1988;Balzan et al 1991aBalzan et al , 1991b. Therefore, we think it of interest to report that the human placenta, after delivery at term and perfused in v i m , continuously releases DLIS into the fetal venous perfusate.…”

Section: Introductionmentioning

confidence: 86%

See 1 more Smart Citation

Release of a Substance From the Human Placenta Having Digoxin‐like Immunoreactivity

Grande

Boura

Read

et al. 1993

Clin Exp Pharma Physio

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1. The human placental lobule, perfused with a constant flow (5 mL/min) of Krebs' solution after delivery at term, released into the fetal perfusate a digoxin-like substance, as measured by a fluorescence polarization immunoassay. 2. Initially the venous concentration was 360 +/- 66.7 pmol/L digoxin equivalents. This level did not change significantly during fetal vasoconstriction induced by prostaglandin F2 alpha infusion and persisted for the duration of the experiment (1.5-2 h). 3. Infusion into the fetal circulation of Fab fragments of sheep antibodies to digoxin caused vasodilatation, indicated by a fall in perfusion pressure. 4. Thus a digoxin-like immunoreactive substance, previously reported to be present in the placenta, is released into the fetal circulation and may play a role in placental control of fetal vascular tone.

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Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 86%

Release of a Substance From the Human Placenta Having Digoxin‐like Immunoreactivity

Grande

Boura

Read

et al. 1993

Clin Exp Pharma Physio

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“…37 The various physiological changes of pregnancy alter the pharmacokinetics of digoxin variably 38 and regular monitoring of serum levels is essential; however, in the third trimester they can appear spuriously high due to digoxin-like substances that interfere with the radioassay. 39 Although digoxin is excreted in breast milk, the dose ingested by infants is small and unlikely to be of clinical significance. 40 Class IA antiarrhythmic agents: quinidine, procainamide and disopyramide These drugs predominantly block sodium channels and also potassium channels.…”

Section: Digoxinmentioning

confidence: 99%

Maternal cardiac arrhythmias during pregnancy and lactation

Cordina

McGuire

2010

Obstet Med

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Arrhythmias occurring during pregnancy can cause significant symptoms and even death in mother and fetus. The management of these arrhythmias is complicated by the need to avoid harm to the fetus and neonate. It is useful to classify patients with arrhythmias into those with and without structural heart disease. Those with a primary electrical problem, but an otherwise normal heart, often tolerate rapid heart rates without compromise whereas patients with problems such as rheumatic heart disease, congenital heart disease or cardiomyopathy may quickly decompensate during an arrhythmia.

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“…Gusdon et al [6] and Valdes [7] reported significantly higher concentrations of digoxinlike immune factor in the serum of preeclamptic women, whereas Gonzalez et al [8] and Phelps et al [9] did not confirm these observations. One recent report found a linear correlation in serum concentrations of digoxin-like immune factor versus the severity of the maternal pre eclampsia [10].…”

Section: Commentmentioning

confidence: 96%