Dihydromyricetin from Ampelopsis grossedentata inhibits melanogenesis through down-regulation of MAPK, PKA and PKC signaling pathways

Huang, Huey-Chun; Liao, Chun-Chieh; Peng, Chu-Chun; Lim, Jia-Min; Siao, Jen-Hung; Wei, Chien-Mei; Chen, Chien-Chih; Wu, Chia-Hung; Chang, Tsong-Min

doi:10.1016/j.cbi.2016.08.023

Cited by 34 publications

(20 citation statements)

References 41 publications

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“…In addition, DHM plays a therapeutic role in the treatment of ischemic stroke [12]. Vine tea has the capability to inhibit melanogenesis and is also used in depigmentation skin care products [13].…”

Section: Introductionmentioning

confidence: 99%

Annotation of genes involved in high level of dihydromyricetin production in vine tea (Ampelopsis grossedentata) by transcriptome analysis

Cao

et al. 2020

BMC Plant Biol

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Background: Leaves of the medicinal plant Ampelopsis grossedentata, which is commonly known as vine tea, are used widely in the traditional Chinese beverage in southwest China. The leaves contain a large amount of dihydromyricetin, a compound with various biological activities. However, the transcript profiles involved in its biosynthetic pathway in this plant are unknown. Results: We conducted a transcriptome analysis of both young and old leaves of the vine tea plant using Illumina sequencing. Of the transcriptome datasets, a total of 52.47 million and 47.25 million clean reads were obtained from young and old leaves, respectively. Among 471,658 transcripts and 177,422 genes generated, 7768 differentially expressed genes were identified in leaves at these two stages of development. The phenylpropanoid biosynthetic pathway of vine tea was investigated according to the transcriptome profiling analysis. Most of the genes encoding phenylpropanoid biosynthesis enzymes were identified and found to be differentially expressed in different tissues and leaf stages of vine tea and also greatly contributed to the biosynthesis of dihydromyricetin in vine tea. Conclusions: To the best of our knowledge, this is the first formal study to explore the transcriptome of A. grossedentata. The study provides an insight into the expression patterns and differential distribution of genes related to dihydromyricetin biosynthesis in vine tea. The information may pave the way to metabolically engineering plants with higher flavonoid content.

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Section: Introductionmentioning

confidence: 99%

Annotation of genes involved in high level of dihydromyricetin production in vine tea (Ampelopsis grossedentata) by transcriptome analysis

Cao

et al. 2020

BMC Plant Biol

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“…The MAPKs can be activated by various extracellular molecules, and induce the phosphorylation of many key signaling molecules related to inflammation, cell proliferation, and apoptosis . A recent study showed that DHM inhibited melanogenesis by inhibiting MAPK signaling pathway in mouse melanoma cells . In another study, DHM alleviated carbon tetrachloride‐induced acute liver injury via JNK‐dependent mechanism in mice .…”

Section: Resultsmentioning

confidence: 98%

Protective effect of dihydromyricetin on LPS-induced acute lung injury

Wang

Xiao

Yang

et al. 2018

Journal of Leukocyte Biology

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Dihydromyricetin (DHM), a bioactive flavonoid component isolated from Ampelopsis grossedentata, is known to have anti-inflammatory effect, but the effect of DHM on acute lung injury (ALI) is largely unknown. Here, we investigated the effect of DHM on ALI and the underlying mechanism by bioinformatic analyses and animal experiments. We found that pretreatment with DHM ameliorated lung pathological changes and suppressed the inflammation response in lung tissues after LPS challenge. The potential targets of DHM were predicted by DDI-CPI and DRAR-CPI tools and analyzed using the STRING server to predict the functionally related signaling pathways, such as MAPK signaling. Molecular docking calculations indicated that DHM could be embedded tightly into the binding pocket of ERK, JNK, and p38. Furthermore, the activation of MAPK signaling induced by LPS was inhibited by DHM. In conclusion, these findings suggest that DHM may exert its protective effect on ALI by inhibiting MAPK signaling. The present study supports a potential clinical application for DHM in treating ALI and provides a novel design that combines in silico methods with in vivo experiments for drug research.

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“…MAPK family, including p38 MAPK, ERK and JNK, is reported to increase in mammalian melanogenesis through MITF degradation [9,[51][52][53]. Interestingly, p38 MAPK, ERK and JNK are also reported to increase in MITF gene expression under oxidative stress [54,55]. Thus, MAPK has many issues to elucidate their roles in the regulation of melanogenesis.…”

Section: Discussionmentioning

confidence: 99%

Methyl-2-acetylamino-3-(4-hydroxyl-3,5-dimethoxybenzoylthio)propanoate suppresses melanogenesis through ERK signaling pathway mediated MITF proteasomal degradation

Jeong

Xuan

et al. 2018

Journal of Dermatological Science

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Dihydromyricetin from Ampelopsis grossedentata inhibits melanogenesis through down-regulation of MAPK, PKA and PKC signaling pathways

Cited by 34 publications

References 41 publications

Annotation of genes involved in high level of dihydromyricetin production in vine tea (Ampelopsis grossedentata) by transcriptome analysis

Annotation of genes involved in high level of dihydromyricetin production in vine tea (Ampelopsis grossedentata) by transcriptome analysis

Protective effect of dihydromyricetin on LPS-induced acute lung injury

Methyl-2-acetylamino-3-(4-hydroxyl-3,5-dimethoxybenzoylthio)propanoate suppresses melanogenesis through ERK signaling pathway mediated MITF proteasomal degradation

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