Dihydromyricetin-Incorporated Multilayer Nanofibers Accelerate Chronic Wound Healing by Remodeling the Harsh Wound Microenvironment

Electroactive nanofibrous membrane with temperature monitoring for wound healing

“…37,38 When a wound that disrupts the epithelial barrier occurs, the wound surface immediately generates an EF pointing from the edge to the center. 39,40 When Ag/Zn@PLA dressings come into contact with blood or wound extrusions, a set of redox reactions between the Ag and Zn electrodes are expected to occur: 41,42 Ag electrode:…”

Amorphizing Metal Selenides-Based ROS Biocatalysts at Surface Nanolayer toward Ultrafast Inflammatory Diabetic Wound Healing

“…The inefficient healing of diabetic ulcers has been widely attributed to the high-ROS-level microenvironments, oxidative-stress effects, and inflammatory responses in chronic wounds, leading to the poor proliferation and differentiation of stem cells and also deterioration of many other functional cells. ,− Therefore, developing ROS-elimination materials to alleviate oxidative stress and relieve the inflammatory environments has provided opportunities to promote inflammatory and refractory wound healing, which include antioxidant nanostructures (catechol-based polymers, carbon nanomaterials, small-molecules-based reductants, , etc .) and antioxidase-like catalytic ROS-scavenging materials. − …”

Luminescent MOF-Based Nanofibers with Visual Monitoring and Antibacterial Properties for Diabetic Wound Healing

“…As one of the main complications of diabetes, diabetic chronic wounds bring huge burden to the global medical system and individuals. , Such wounds are difficult to heal because their hyperglycemic microenvironment is conducive to bacterial growth. − At present, a variety of dressings have been developed to accelerate wound healing, such as aerogels, , sponges, , hydrogels, , foams, , and electrospinning nanofibers (NFs). , Among them, electrospinning NFs have been proposed as competitive candidate materials for wound dressing due to their good biocompatibility, appropriate porosity, large specific surface, and three-dimensional (3D) network structure simulating the extracellular matrix. , The wound condition is usually assessed by professional medical personnel, and it is always needed to physically open the dressing for further empirical judgment, such a procedure will not only induce secondary infection of the wound but also cause pain to the patient . Previous reports have proved that the pH change of wound exudate can dynamically reflect the wound status during the healing process of infected wounds. − Therefore, it is urgent to develop a multifunctional wound dressing with effective antibacterial and visual pH monitoring capabilities for diabetic wound management.…”

“…3−5 At present, a variety of dressings have been developed to accelerate wound healing, such as aerogels, 6,7 sponges, 8,9 hydrogels, 10,11 foams, 12,13 and electrospinning nanofibers (NFs). 14,15 Among them, electrospinning NFs have been proposed as competitive candidate materials for wound dressing due to their good biocompatibility, appropriate porosity, large specific surface, and three-dimensional (3D) network structure simulating the extracellular matrix. 16,17 The wound condition is usually assessed by professional medical personnel, and it is always needed to physically open the dressing for further empirical judgment, such a procedure will not only induce secondary infection of the wound but also cause pain to the patient.…”