Dihydrophenanthrenes from medicinal plants of Orchidaceae: A review

Qi, Jiaxin; Zhou, Di; Jiang, Wanru; Chen, Gang; Li, Wei; Li, Ning

doi:10.1016/j.chmed.2021.10.004

Cited by 7 publications

(2 citation statements)

References 71 publications

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“…DKK1 overexpression could be a marker for efficient therapy of gastro-oesophageal carcinoma with DKN-01. This chemical is being tested in individuals with endometrial, uterus, or ovarian as monotherapy or conjunction with paclitaxel in phase 2 research (ClinicalTrials.gov Identifier: NCT03395080) 70 .…”

Section: Therapeutic Targets and Drugsmentioning

confidence: 99%

An in-Depth Analysis of Ovarian Cancer: Pathogenesis and Clinical Manifestation

Mahmood

Ved²,

Siddiqui

et al. 2022

Drug Res (Stuttg)

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Ovarian cancer is characterized by the establishment of tolerance, the recurrence of disease, as well as a poor prognosis. Gene signatures in ovarian cancer cells enable cancer medicine research, therapy, prevention, & management problematic. Notwithstanding advances in tumor puncture surgery, novel combinations regimens, and abdominal radiation, which can provide outstanding reaction times, the bulk of gynecological tumor patients suffer from side effects & relapse. As a consequence, more therapy alternatives for individuals with ovarian cancer must always be studied to minimize side effects and improve progression-free and total response rates. The development of cancer medications is presently undergoing a renaissance in the quest for descriptive and prognostic ovarian cancer biomarkers. Nevertheless, abnormalities in the BRCA2 or BRCA1 genes, a variety of hereditary predispositions, unexplained onset and progression, molecular tumor diversity, and illness staging can all compromise the responsiveness and accuracy of such indicators. As a result, current ovarian cancer treatments must be supplemented with broad-spectrum & customized targeted therapeutic approaches. The objective of this review is to highlight recent contributions to the knowledge of the interrelations between selected ovarian tumor markers, various perception signs, and biochemical and molecular signaling processes, as well as one’s interpretation of much more targeted and effective treatment interventions.

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Section: Therapeutic Targets and Drugsmentioning

confidence: 99%

An in-Depth Analysis of Ovarian Cancer: Pathogenesis and Clinical Manifestation

Mahmood

Ved²,

Siddiqui

et al. 2022

Drug Res (Stuttg)

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“…Dihydrophenanthrenes are important class of molecules which are found in several bioactive compounds such as lusianthridin, juncusol and erianthridin (Scheme 1B). [9] These compounds are used extensively in traditional Chinese medicine and display antitumor, antifibrotic, antioxidant, antiplatelet aggregation properties. [10] Owing to their diverse biological activities the dihydrophenanthrenes are important synthetic target (Scheme 1C).…”

Section: Introductionmentioning

confidence: 99%

Photocatalytic Electrocyclization for the Synthesis of Dihydrophenanthrenes

Singh,

Kant,

Tripathi

2024

Asian J Org Chem

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Palladium‐Catalyzed Skeletal Rearrangement of Substituted 2‐Silylaryl Triflates via 1,5‐C−Pd/C−Si Bond Exchange

Hayashi,

Tsuda,

Shintani

2023

Angewandte Chemie

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A palladium‐catalyzed skeletal rearrangement of 2‐(2‐allylarylsilyl)aryl triflates has been developed to give highly fused tetrahydrophenanthrosilole derivatives via unprecedented 1,5‐C−Pd/C−Si bond exchange. The reaction pathways can be switched toward 4‐membered ring‐forming C(sp2)−H alkylation by tuning the reaction conditions to give completely different products, fused dihydrodibenzosilepin derivatives, from the same starting materials. The inspection of the reaction conditions revealed the importance of carboxylates in promoting the C−Pd/C−Si bond exchange.

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Dihydrophenanthrenes from medicinal plants of Orchidaceae: A review

Cited by 7 publications

References 71 publications

An in-Depth Analysis of Ovarian Cancer: Pathogenesis and Clinical Manifestation

An in-Depth Analysis of Ovarian Cancer: Pathogenesis and Clinical Manifestation

Photocatalytic Electrocyclization for the Synthesis of Dihydrophenanthrenes

Palladium‐Catalyzed Skeletal Rearrangement of Substituted 2‐Silylaryl Triflates via 1,5‐C−Pd/C−Si Bond Exchange

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