Dilatation of the Ascending Aorta Is Associated with Low Serum Prolidase Activity

Akçakoyun, Mustafa; Pala, Selçuk; Esen, Özlem; Açar, Göksel; Kargın, Ramazan; Emiroğlu, Yunus; Tigen, Kürşat; Özcan, Ömer; İpçioğlu, Osman Metin; Esen, Ali Metin

doi:10.1620/tjem.220.273

Cited by 13 publications

(9 citation statements)

References 19 publications

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“…We found that the SPA was significantly lower in patients with PEX syndrome versus healthy controls, but the differences between PEX syndrome with and without glaucoma were not significant. Low SPA was reported in some degenerative diseases like Parkinson's Disease, ascending aortic aneurysm, and degenerative myopia [27][28][29]. Low SPA increases proline-rich protein.…”

Section: Discussionmentioning

confidence: 99%

Serum prolidase activity and oxidative stress in patients with pseudoexfoliation syndrome

Tetikoğlu

Sağdık

Aktaş

et al. 2016

Graefes Arch Clin Exp Ophthalmol

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Section: Discussionmentioning

confidence: 99%

Serum prolidase activity and oxidative stress in patients with pseudoexfoliation syndrome

Tetikoğlu

Sağdık

Aktaş

et al. 2016

Graefes Arch Clin Exp Ophthalmol

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“…Mutations in the prolidase gene (PEPD, 19cen-q13.11) cause prolidase deficiency (PD; MIM 170100) [ 21 ]. Low prolidase activity may cause many diseases [ 21 – 24 ]. Mental retardation, extraordinary facial appearance, skeletal deformities, joint dislocations, hematological anomalies, splenomegaly, chronic infections and chronic skin ulcers in particular may be observed due to prolidase deficiency [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Prolidase activity in chronic plaque psoriasis patients

Sürücü

Aksoy

Ozgöztas

et al. 2015

pdia

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IntroductionPsoriasis is a chronic, inflammatory, T-cell-mediated and hyperproliferative skin disease characterized by erythematous, squamous, sharply circumscribed and infiltrated plaques. The metabolisms of the collagen proteins undergo considerable changes due to the acceleration of their turnovers as a result of increased prolidase activity in psoriasis patients.AimTo determine the level of prolidase activity in psoriasis patients and evaluate its relationship with the oxidative system.Material and methodsThe serum prolidase enzyme activity, total antioxidant levels and total oxidant levels of 40 psoriasis patients and a control group including 47 healthy individuals were analyzed by using their serum samples, and their oxidative stress indices were calculated.ResultsThe prolidase levels (p < 0.01), total oxidant levels (p < 0.01) and oxidative stress index levels (p < 0.001) of the patient group were higher than the corresponding parameters in the control group. The total antioxidant level was low (p < 0.01). Although a positive correlation was found between the prolidase and total antioxidant levels and the total oxidant level, no correlation was found between prolidase and the oxidative stress index.ConclusionsIt has been determined that the activity of the prolidase enzyme increases due to the increased collage turnover in psoriasis patients. Increased serum oxidant levels and oxidative stress indices values may play a role in the pathogenesis of psoriasis.

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“…Previous studies have mentioned that this occurs via the interaction of a type 1 collagen with the b1-integrin receptor in human skin, [7] Savaş et al [18] designed a similar study in which they measured the serum prolidase levels in patients with erectile dysfunction and obtained significant results as elevated serum prolidase activity is related with erectile dysfunction. In addition, Akçakoyun et al [19] reported low serum prolidase levels in patients with ascending aortic dilatation. A study by Surazynski et al [20] claimed that prolidase may have an unrecognized role in angiogenic signaling, and they determined that the overexpression of prolidase is related to increased levels of nuclear hypoxia-inducible factor-1 alpha (HIF-1).…”

Section: Discussionmentioning

confidence: 99%

Can elevated prolidase activity predict the duration of ischemic exposure in different types of ischemia?

Yavuz¹

2013

Turk Gogus Kalp Dama

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Bu çalışmada farklı iskemi tiplerinde serum prolidaz aktivitesi ve iskemi süresi arasındaki ilişkinin belirlenmesi amaçlandı. Ça lış ma pla nı: Kırk erkek Sprague-Dawley cinsi sıçan beş eşit gruba bölündü. Grup 1'deki sıçanlar (kontrol grubu) bazal serum prolidaz düzeylerinin belirlenmesi için herhangi bir işlem uygulanmadan sakrifiye edildi ve kan örnekleri alındı. Grup 2 ve 3'de mezenterik iskemi oluşturmak için basit laparotomi yapılarak, superior mezenterik arterler klemplendi. Grup 4 ve 5'de periferik iskemi oluşturmak için sağ ana femoral arter klemplenerek sırasıyla 120. ve 360. dakikalarda kan örnekleri alındı. Tüm gruplardan elde edilen örneklerden serum prolidaz düzeyi ölçüldü. Bul gu lar: Sıçanlardaki bazal prolidaz düzeyleri 266.8±20.5 U/L olarak bulundu. Periferik (404.0±105.6 U/L) ve mezenterik iskeminin (317.1±121.4 U/L) iki saat sonrasında serum prolidaz aktiviteleri arttı. Ancak, periferik (346.1±104.9 U/L) ve mezenterik iskeminin (233.4±36.6 U/L) altı saat sonrasında serum prolidaz düzeyleri azaldı. Serum prolidaz düzeyleri mezenterik iskemide artmasında rağmen, bu periferik iskemide iki saat sonra elde edilen enzim düzeylerinden daha düşüktü (p=0.006). So nuç: Serum prolidaz aktivitesi, iskemi süresinin belirlenmesinde önemli bir öngördürücü biyobelirteç olabilir. Anah tar söz cük ler: Biyobelirteç; iskemi süresi; mezenterik iskemi; periferik iskemi; prolidaz düzeyi. Background:This study aims to determine the relationship between serum prolidase activity and ischemia duration in different ischemia types. Methods: Forty male Sprague Dawley rats were divided into five equal groups. The rats were sacrificed and blood samples were obtained to determine the basal serum prolidase levels in group 1 (control group) without any intervention. In groups 2 and 3, the superior mesenteric arteries were clamped with simple laparotomy to induce mesenteric ischemia. In groups 4 and 5, the right common femoral artery was clamped to induce peripheral ischemia and blood samples were taken at 120 and at 360 minutes, respectively. The serum prolidase levels were measured using the samples obtained from each group. Results: The basal prolidase level in rats was found to be 266.8±20.5 U/L. The serum prolidase levels increased after two-hours of peripheral (404.0±105.6 U/L) and mesenteric ischemia (317.1±121.4 U/L). However, the serum prolidase levels decreased after six-hours of peripheral (346.1±104.9 U/L) and mesenteric ischemia (233.4±36.6 U/L). Although the serum prolidase levels were elevated in the second hour of mesenteric ischemia, they were lower than the enzyme levels obtained after twohours of peripheral ischemia (p= 0.006). Conclusion: The serum prolidase level may be an important predictive biomarker for identifying the duration of ischemia.

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Dilatation of the Ascending Aorta Is Associated with Low Serum Prolidase Activity

Cited by 13 publications

References 19 publications

Serum prolidase activity and oxidative stress in patients with pseudoexfoliation syndrome

Serum prolidase activity and oxidative stress in patients with pseudoexfoliation syndrome

Prolidase activity in chronic plaque psoriasis patients

Can elevated prolidase activity predict the duration of ischemic exposure in different types of ischemia?

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