Dimecarbin, a new antihypertensive agent

Nenitzescu Synthesis of 5‐Hydroxyindoles with Zinc, Iron and Magnesium Salts in Cyclopentyl Methyl Ether

“…Interestingly compound 4 ad was obtained with a considerably higher yield (50 %) compared to literature (15 %). [7] The reaction was run on a gram scale to give dimecarbine (mecarbinate, 5) an antihypertensive drug [42] and an intermediate in the synthesis of antiviral Arbidol, (6) [43] with an isolated yield of 65 % (Figure 1). The use of CPME have some additional advantages over other solvents, for instance the possibility to telescope the reactions shown in Scheme 4.…”