Dimensão fractal na quantificação do grau de rejeição celular miocárdica pós-transplante cardíaco

Moreira, Roberto Douglas; Moriel, A R; Murta, Leonardo; Neves, Leandro Alves; Godoy, Moacir Fernandes de

doi:10.1590/s0102-76382011000200004

Cited by 21 publications

(18 citation statements)

References 11 publications

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“…However, currently these microscopic changes are evaluated qualitatively, which does not enable quantification of morphological changes. To this end, fractal analysis has been studied as it presents itself as a tool that enables the quantification of histological findings, in addition to eliminating variations between raters (Lee et al, 2014;Moreira et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Fractal Analysis of Skeletal Muscle Tissue of Rats Subjected to Stretch Injury

et al. 2015

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SUMMARY:The aim of this study was to analyze changes in the skeletal muscle tissue of rats after muscle stretch injury using fractal analysis. Nineteen rats were divided into three groups, Control (n= 5) (C), Lesion two days (n= 7) (L2), and Lesion seven days (n= 7) (L7). Histological slides of the gastrocnemius muscle of the animals were prepared and stained with Hematoxylin and eosin for analysis of the inflammatory process, and picrosirius for the demonstration of collagen. The stained slides were subsequently analyzed using Fractal Dimension (FD). The results showed high FD values of the inflammatory process in the experimental groups L2 and L7 in relation to C (p= 0.000). The analysis of collagen in the picrosirius stained slides showed high FD in the L2 group compared to the L7 (p= 0.0001), with no statistically significant difference among other groups. In summary, the present study demonstrated that fractal analysis was able to identify changes in the inflammatory process in injured skeletal muscle tissue.

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Section: Introductionmentioning

confidence: 99%

Fractal Analysis of Skeletal Muscle Tissue of Rats Subjected to Stretch Injury

et al. 2015

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“…Several studies have evaluated fractal dimensioning of histological slides to identify histological changes in several experiments, for example: assessing the degree of tumor invasiveness by quantifying the fractal dimension of the malignant epithelium/ stroma interface 40 , liver tissue with different degrees of cirrhosis due to hepatitis C 41 , identification of dysplasia of lesions in oral cavity epithelium 42 , in a study of quantification of the degree of myocardial cell rejection 43 , estimation of nephron integrity 14 and study pointed out that the vascular networks indirectly reflecting the architecture of stromal frameworks might have measurable and understandable differences between renal oncocytomas and ChRCCs (chromophobe renal cell carcinomas) 44 .…”

Section: ■ Discussionmentioning

confidence: 99%

New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory

et al. 2019

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“…It is well known that tissue structural changes can be quantified by the fractal dimension and Shannon entropy [ 11 . 12 ] .…”

Section: Introductionmentioning

confidence: 99%

“…Using fractal analysis. Arruda et al [ 11 ] and Douglas et al [ 12 ] correlated the degree of dedifferentiation and tumor invasiveness in prostate cancer and degree of rejection of cardiac tumors. respectively.…”

Section: Introductionmentioning

confidence: 99%

Comparison of fractal dimension and Shannon entropy in myocytes from rats treated with histidine-tryptophan-glutamate and histidine-tryptophan cetoglutarate.

Oliveira¹,

Brandi²,

Santos³

et al. 2014

Revista Brasileira De Cirurgia Cardiovascular

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IntroductionSolutions that cause elective cardiac arrest are constantly evolving, but the ideal compound has not yet been found. The authors compare a new cardioplegic solution with histidine-tryptophan-glutamate (Group 2) and other one with histidine-tryptophan-cetoglutarate (Group 1) in a model of isolated rat heart.ObjectiveTo quantify the fractal dimension and Shannon entropy in rat myocytes subjected to cardioplegia solution using histidine-tryptophan with glutamate in an experimental model, considering the caspase markers, IL-8 and KI-67.MethodsTwenty male Wistar rats were anesthetized and heparinized. The chest was opened, the heart was withdrawn and 40 ml/kg of cardioplegia (with histidine-tryptophan-cetoglutarate or histidine-tryptophan-glutamate solution) was infused. The hearts were kept for 2 hours at 4ºC in the same solution, and thereafter placed in the Langendorff apparatus for 30 min with Ringer-Locke solution. Analyzes were performed for immunohistochemical caspase, IL-8 and KI-67.ResultsThe fractal dimension and Shannon entropy were not different between groups histidine-tryptophan-glutamate and histidine-tryptophan-acetoglutarate.ConclusionThe amount of information measured by Shannon entropy and the distribution thereof (given by fractal dimension) of the slices treated with histidine-tryptophan-cetoglutarate and histidine-tryptophan-glutamate were not different, showing that the histidine-tryptophan-glutamate solution is as good as histidine-tryptophan-acetoglutarate to preserve myocytes in isolated rat heart.

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Dimensão fractal na quantificação do grau de rejeição celular miocárdica pós-transplante cardíaco

Cited by 21 publications

References 11 publications

Fractal Analysis of Skeletal Muscle Tissue of Rats Subjected to Stretch Injury

Fractal Analysis of Skeletal Muscle Tissue of Rats Subjected to Stretch Injury

New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory

Comparison of fractal dimension and Shannon entropy in myocytes from rats treated with histidine-tryptophan-glutamate and histidine-tryptophan cetoglutarate.

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