Comparison of fractal dimension and Shannon entropy in myocytes from rats treated with histidine-tryptophan-glutamate and histidine-tryptophan cetoglutarate.

Oliveira, Marcos Aurélio Barboza de; Brandi, Antônio Carlos; Santos, Carlos Alberto dos; Botelho, Paulo Henrique Husseni; Cortez, Jose L.; Godoy, Moacir Fernandes de; Braile, Domingo Marcolino

doi:10.5935/1678-9741.20140052

Cited by 13 publications

(11 citation statements)

References 23 publications

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“…Another interesting aspect would be the analysis of variations of the HTK solution. A Brazilian study, published in 2014, found no difference between the original composition and another one with glutamate replacing ketoglutarate in an experimental model with rats [25] .…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Myocardial Protection with HTK Solution and Hypothermic Hyperkalemic Blood Solution in the Correction of Acyanogenic Congenital Cardiopathies – A Randomized Study

Valente

Lustosa

Mota

et al. 2019

Braz J Cardiovasc Surg

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Objective The goal of the present study was to compare the myocardial protection obtained with histidine-tryptophan-ketoglutarate (HTK) cardioplegic solution (Custodiol ® ) and with intermittent hypothermic blood solution. Methods Two homogenous groups of 25 children with acyanotic congenital heart disease who underwent total correction with mean aortic clamping time of 60 minutes were evaluated in this randomized study. Troponin and creatine kinase-MB curves, vasoactive-inotropic score, and left ventricular function were obtained by echocardiogram in each group. The values were correlated and presented through graphs and tables after adequate statistical treatment. Results It was observed that values of all the studied variables varied over time, but there was no difference between the groups. Conclusion We conclude that in patients with acyanotic congenital cardiopathies submitted to total surgical correction, mean aortic clamping time around one hour, and cardiopulmonary bypass with moderate hypothermia, the HTK crystalloid cardioplegic solution offers the same myocardial protection as the cold-blood hyperkalemic cardioplegic solution analyzed, according to the variables considered in our study model.

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Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Myocardial Protection with HTK Solution and Hypothermic Hyperkalemic Blood Solution in the Correction of Acyanogenic Congenital Cardiopathies – A Randomized Study

Valente

Lustosa

Mota

et al. 2019

Braz J Cardiovasc Surg

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“…Outro estudo 25 observou em seus estudos a eficácia da utilização da DF para verificar alterações morfológicas sobre o tecido muscular cardíaco de ratos. O miocárdio ventricular pode adaptar-se a estresses sofridos em sua estrutura, conservando sua inicialmente sua dimensão fractal.…”

Section: Discussionunclassified

Ingestão De Dicromato De Potássio Induz Alterações Morfológicas Em Cardiomiócitos De Ratos

Magalhães

Lorençoni

2020

COLLOQ VITAE

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The aim of this studywas to analyze the effects of diet’s potassium dichromate supplementation on cardiac muscle tissue morphology in rats. Forty male rats were used, divided into G0: basal diet, G1: basal diet + 12 mg.Kg-1potassium dichromate, G2: basal diet + 24 mg.Kg-1and G3: basal diet + 36 mg.Kg-1for 90 days. The animals were euthanized, with heart extraction for morphological analysis and fractal dimension analysis. Anova One-Way, Kruskall-Wallis, Tukey and Dunnwere used to compare the results, with p<0.05. There is no differences on body mass and heart mass. G1showed greater tissue inflammation of compared to G2 and G0. It was concluded that potassium dichromate generatesmorphological changes byproinflammatory effect in rat cardiomyocytes.

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“…Many authors have discussed the effects of the different types of cardioplegia [ 9 - 11 ] . Antegrade and/or retrograde delivery of cardioplegia has also been a matter of constant debate [ 12 - 14 ] .…”

Section: Discussionmentioning

confidence: 99%

Coronary Perfusion Pressure during Antegrade Cardioplegia in On-Pump CABG Patients

Lopes¹,

Júnior²

2017

Braz J Cardiovasc Surg

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ObjectiveThe aim of this study was to investigate whether aortic tension estimated by palpation and cardioplegia infusion line pressure provide results equivalent to those obtained with direct aortic intraluminal pressure measurement.MethodsSixty consecutive patients who underwent coronary artery bypass graft surgeries with extracorporeal circulation were analyzed. Sanguineous cardioplegic solution in a ratio of 4:1 was administered using a triple lumen antegrade cannula. After crossclamping, cardioplegia was infused and aortic root pressure was recorded by surgeon (A) considering the aortic tension he felt in his fingertips. At the same time, another surgeon (B) recorded his results for the same measurement. Concomitantly, the anesthesiologist recorded intraluminal pressure in the aortic root and the perfusionist recorded delta pressure in cardioplegia infusion line. None of the participants involved in these measurements was allowed to be informed about the values provided by the other examiners.ResultsThe Bland-Altman test showed that a considerable variation between aortic wall tension was found as measured by palpation and by intraluminal pressure, with a bias of -9.911±18.75% (95% limits of agreement: -46.7 to 26.9). No strong correlation was observed between intraluminal pressure and cardioplegia line pressure (Spearman's r=0.61, 95% confidence interval 0.5-0.7; P<0.0001).ConclusionThese findings reinforce that cardioplegia infusion should be controlled by measuring intraluminal pressure, and that palpation and cardioplegia line pressure are inaccurate methods, the latter should always be used to complement intraluminal measurement to ensure greater safety in handling the cardioplegia circuit.

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Comparison of fractal dimension and Shannon entropy in myocytes from rats treated with histidine-tryptophan-glutamate and histidine-tryptophan cetoglutarate.

Cited by 13 publications

References 23 publications

Comparative Analysis of Myocardial Protection with HTK Solution and Hypothermic Hyperkalemic Blood Solution in the Correction of Acyanogenic Congenital Cardiopathies – A Randomized Study

Comparative Analysis of Myocardial Protection with HTK Solution and Hypothermic Hyperkalemic Blood Solution in the Correction of Acyanogenic Congenital Cardiopathies – A Randomized Study

Ingestão De Dicromato De Potássio Induz Alterações Morfológicas Em Cardiomiócitos De Ratos

Coronary Perfusion Pressure during Antegrade Cardioplegia in On-Pump CABG Patients

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