Dimensionless analysis on liquid–liquid two-phase flow patterns in a numbered-up microfluidic device

Asadi-Saghandi, Hamid; Karimi-Sabet, Javad; Ghorbanian, Sohrab Ali; Moosavian, Seyed Mohammad Ali

doi:10.1016/j.cej.2021.132428

Cited by 21 publications

(10 citation statements)

References 32 publications

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“…These maps could be sketched according to the flow rate of binary systems, but they cannot be used as a general representation as they do not take into account all factors that impact the flow sketches. Therefore, researchers have suggested dimensionless quantities, such as Re, We, and Ca, to create general flow configuration maps 45 . Various mixtures of these dimensionless quantities were utilized as coordinates for generalized flow diagrams.…”

Section: Introductionmentioning

confidence: 99%

Computational fluid dynamics simulation of two-phase flow patterns in a serpentine microfluidic device

Amini

Ghazanfari

Heydari

et al. 2023

Sci Rep

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In the current research work, the flow behavior of a liquid–liquid extraction (LLE) process in a serpentine microchannel was analyzed. The simulation was performed using a 3D model and the results were found to be consistent with experimental data. The impact of the flow of chloroform and water on the flow model was also examined. The data indicate that once the aqua and organic phases flow rates are low and similar, a slug flow pattern is observed. However, as the overall flow rate raises, the slug flow transforms into parallel plug flow or droplet flow. An increment in the aqua flows while maintaining a constant organic phase flow rate results in a transition from slug flow to either droplet flow or plug flow. Finally, the patterns of flow rate in the serpentine micro-channel were characterized and depicted. The results of this study will provide valuable insights into the behavior of two-phase flow patterns in serpentine microfluidic devices. This information can be used to optimize the design of microfluidic devices for various applications. Furthermore, the study will demonstrate the applicability of CFD simulation in investigating the behavior of fluids in microfluidic devices, which can be a cost-effective and efficient alternative to experimental studies.

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Section: Introductionmentioning

confidence: 99%

Computational fluid dynamics simulation of two-phase flow patterns in a serpentine microfluidic device

Amini

Ghazanfari

Heydari

et al. 2023

Sci Rep

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“…These regimes depend on the physical properties of the fluids (i.e. interfacial tension and viscosity) (Tice et al, 2004), the linear velocity (Burns and Ramshaw, 1999) and the flowrates of the fluids (Zhao and Middelberg, 2011), the microchannel size, geometry (Kashid and Agar, 2007), material (Ahmed et al, 2006) and wettability (Asadi-Saghandi et al, 2021;Dessimoz et al, 2008). 𝜚, 𝑢, 𝛾 and 𝑙 are viscosity, density, superficial velocity, interfacial tension and characteristic length, respectively).…”

Section: Introductionmentioning

confidence: 99%

“…Later on, Cao et al (2018) studied experimentally four different liquid-liquid systems in a non-circular glass microchannel and presented clear transitions between the different drop formation patterns by using 𝑅𝑒 and 𝑊𝑒 as coordinates. In a recent study, Asadi-Saghandi et al (2021) performed experiments with six liquid-liquid systems in a microdevice with 4 microchannels with Y inlets. They were able to reduce the overlapping of the flow regimes from 10.1% to 3% by using 𝐶𝑎 0.31 , 𝑊𝑒 0.07 and 𝑊𝑒 0.25 𝑂ℎ 0.31 as coordinates to the flow pattern maps.…”

Section: Introductionmentioning

confidence: 99%

“…Most available studies on the drop formation flow regimes in microchannels have been conducted with pure fluids (Asadi-Saghandi et al, 2021;Cao et al, 2018;Cubaud and Mason, 2008;Darekar et al, 2017;Dessimoz et al, 2008;Kashid and Agar, 2007;Lei et al, 2021;Mastiani et al, 2017;Salim et al, 2008;Shahriari et al, 2016;Tsaoulidis et al, 2013;Wu et al, 2017;Yagodnitsyna et al, 2016;Zhao et al, 2006), and only limited works have considered surfactants (Anna and Mayer, 2006;Carneiro et al, 2019;Fu et al, 2012;Kovalchuk et al, 2019Kovalchuk et al, , 2018bRoumpea et al, 2019). Roumpea et al (2019) and Kovalchuk et al (2018b) identified 4 different regimes, including squeezing, dripping, threading and jetting flows, using silicone oil as the continuous phase and water-glycerol solutions with and without different 4 cationic surfactants as the dispersed phase.…”

Section: Introductionmentioning

confidence: 99%

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Effect of surfactants on drop formation flow patterns in a flow-focusing microchannel

Kalli

Angeli

2022

Chemical Engineering Science

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“…In isotropic etching, since a material is under attack in all directions, a geometry is created that is very similar to a semicircle (Ziaie et al 2004; Sadeghi, Sadeghi & Saidi 2016). Accordingly, semicircular microchannels are used not only by the scientific community (Hisamoto et al 2003; Asadi-Saghandi et al 2022) but also in commercial products such as the Dolomite Y-junction chips designed for the observation of the dispersion process (). The datasheet of the Dolomite product, sketched schematically in figure 1( a ) by exaggerating the differences it has from a semicircular geometry, indicates a channel radius-to-depth ratio of , which is very close to unity.…”

Section: Introductionmentioning

confidence: 99%

Unsteady convective–diffusive transport in semicircular microchannels with irreversible wall reaction

Azari

Sadeghi

2022

J. Fluid Mech.

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The unsteady dispersion of a solute band by a steady pressure-driven flow in a semicircular microchannel is theoretically studied via the generalized dispersion model. Considering an irreversible first-order reaction at the curved wall while assuming a no-flux boundary condition at the flat wall, analytical solutions are obtained for the exchange, convection and dispersion coefficients as well as the dimensionless forms of solute concentration and mean solute concentration. The solutions are obtained assuming an initial solute band of arbitrary cross-sectional shape and axial distribution and the results are presented for both circular and semicircular shapes with the uniform distribution being a special case of the latter. Besides the general solutions, special solutions are also derived for uniform velocity and no-reaction cases. In the following, the influences of the initial concentration distribution and the Damköhler number, a measure of the reaction rate, on the transport coefficients and the concentration distribution are investigated in depth. It is demonstrated that the combination of the initial concentration distribution and the Damköhler number specifies the variations of the transport coefficients in the short term but the Damköhler number is the only parameter dominating the long-term values: the exchange and convection coefficients are increasing functions of the Damköhler number whereas the opposite is true for the dispersion coefficient. Moreover, we show that, provided the solute injection is appropriately positioned and shaped, liquid-phase transportation with little dispersion is possible in typical microchannels utilizing semicircular geometry.

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Dimensionless analysis on liquid–liquid two-phase flow patterns in a numbered-up microfluidic device

Cited by 21 publications

References 32 publications

Computational fluid dynamics simulation of two-phase flow patterns in a serpentine microfluidic device

Computational fluid dynamics simulation of two-phase flow patterns in a serpentine microfluidic device

Effect of surfactants on drop formation flow patterns in a flow-focusing microchannel

Unsteady convective–diffusive transport in semicircular microchannels with irreversible wall reaction

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