Dimensions of Oppositional Defiant Disorder in Young Children: Heterotypic Continuity with Anxiety and Depression

Lavigne, John V.; Gouze, Karen R.; Bryant, Fred B.; Hopkins, Joyce

doi:10.1007/s10802-014-9853-1

Cited by 40 publications

(37 citation statements)

References 51 publications

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“…substance use disorders), or were not assessed at intake in at least part of the sample (internalizing disorders), and thus could not be accounted for in models. Not surprisingly, others have found weaker relationships between ODD and later psychopathology after adjusting for initial psychopathology (Lavigne et al., ; Stringaris & Goodman, ). Second, as with many longitudinal studies, attrition occurred in this study, resulting in decreased sample size (and power) during the follow‐up assessment.…”

Section: Discussionmentioning

confidence: 93%

Oppositional defiant disorder dimensions: genetic influences and risk for later psychopathology

Mikolajewski

Taylor

Iacono

2017

Child Psychology Psychiatry

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Background This study was undertaken to determine how well two Oppositional Defiant Disorder (ODD) dimensions (irritable and headstrong/hurtful) assessed in childhood predict late adolescent psychopathology and the degree to which these outcomes can be attributed to genetic influences shared with ODD dimensions. Methods Psychopathology was assessed via diagnostic interviews of 1225 twin pairs at ages 11 and 17. Results Consistent with hypotheses, the irritable dimension uniquely predicted overall internalizing problems, whereas the headstrong/hurtful dimension uniquely predicted substance use disorder symptoms. Both dimensions were predictive of antisocial behavior, and overall externalizing problems. The expected relationships between the irritable dimension and specific internalizing disorders were not found. Twin modeling showed the irritable and headstrong/hurtful dimensions were related to late adolescent psychopathology symptoms through common genetic influences. Conclusions Symptoms of ODD in childhood pose a significant risk for various mental health outcomes in late adolescence. Further, common genetic influences underlie the covariance between irritable symptoms in childhood and overall internalizing problems in late adolescence, whereas headstrong/hurtful symptoms share genetic influences with substance use disorder symptoms. Antisocial behavior and overall externalizing share common genetic influences with both the irritable and headstrong/hurtful dimensions.

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Section: Discussionmentioning

confidence: 93%

Oppositional defiant disorder dimensions: genetic influences and risk for later psychopathology

Mikolajewski

Taylor

Iacono

2017

Child Psychology Psychiatry

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“…This is demonstrated in the correlation between infant RT scores and parent‐rated child behaviors a decade or more later. This demonstrates a kind of correlation that is called heterotypic continuity (Lavigne et al ., ; Miller et al ., ; Putnam et al ., ). So, while the weak correlation is a weakness, there are some indications that the genetic associations are valid.…”

Section: Discussionmentioning

confidence: 99%

“…For this study, we used summary scores for Inattention (which included six items), Impulsivity (which included nine items), and ADHD Symptoms (which is a summary of Inattention and Impulsivity). These scores were used in an attempt to establish heterotypic continuity (Lavigne, Gouze, Bryant & Hopkins, 2014;Miller, Vaillancourt & Boyle, 2009;Putnam, Rothbart & Gartstein, 2008) between the infant reflexive attention task and later child behavior.…”

Section: Child Scoresmentioning

confidence: 99%

Genetic associations with reflexive visual attention in infancy and childhood

Lundwall

Dannemiller

Goldsmith

2015

Developmental Science

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This study elucidates genetic influences on reflexive (as opposed to sustained) attention in children (aged 9 –16 years; N = 332) who previously participated as infants in visual attention studies using orienting to a moving bar (Dannemiller, 2004). We investigated genetic associations with reflexive attention measures in infancy and childhood in the same group of children. The genetic markers (single nucleotide polymorphisms and variable number tandem repeats on the genes APOE, BDNF, CHRNA4, COMT, DRD4, HTR4, IGF2, MAOA, SLC5A7, SLC6A3, and SNAP25) are related to brain development and/or to the availability of neurotransmitters such as acetylcholine, dopamine, or serotonin. This study shows that typically developing children have differences in reflexive attention associated with their genes, as we found in adults (Lundwall, Guo, & Dannemiller, 2012). This effort to extend our previous findings to outcomes in infancy and childhood was necessary because genetic influence may differ over the course of development. Although two of the genes that were tested in our adult study (Lundwall et al., 2012) were significant in either our infant study (SLC6A3) or child study (DRD4), the specific markers tested differed. Performance on the infant task was associated with SLC6A3. In addition, several genetic associations with an analogous child task occurred with markers on CHRNA4, COMT, and DRD4. Interestingly, the child version of the task involved an interaction such that which genotype group performed poorer on the child task depended on whether we were examining the higher or lower infant scoring group. These findings are discussed in terms of genetic influences on reflexive attention in infancy and childhood.

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“…Such findings establish heterotypic continuity (Putnam et al, 2008; Miller et al, 2009; Lavigne et al, 2014) between the infant reflexive attention task and later child behavior.…”

Section: Discussionmentioning

confidence: 67%

MAOA Influences the Trajectory of Attentional Development

Lundwall

Rasmussen

2016

Front. Hum. Neurosci.

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Attention is vital to success in all aspects of life (Meck and Benson, 2002; Erickson et al., 2015), hence it is important to identify biomarkers of later attentional problems early enough to intervene. Our objective was to determine if any of 11 genes (APOE, BDNF, HTR4, CHRNA4, COMT, DRD4, IGF2, MAOA, SLC5A7, SLC6A3, and SNAP25) predicted the trajectory of attentional development within the same group of children between infancy and childhood. We recruited follow up participants from children who participated as infants in visual attention studies and used a similar task at both time points. Using multilevel modeling, we associated changes in the participant’s position in the distribution of scores in infancy to his/her position in childhood with genetic markers on each of 11 genes. While all 11 genes predicted reaction time (RT) residual scores, only Monoamine oxidase A (MAOA) had a significant interaction including time point. We conclude that the MAOA single nucleotide polymorphism (SNP) rs1137070 is useful in predicting which girls are likely to develop slower RTs on an attention task between infancy and childhood. This early identification is likely to be helpful in early intervention.

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Dimensions of Oppositional Defiant Disorder in Young Children: Heterotypic Continuity with Anxiety and Depression

Cited by 40 publications

References 51 publications

Oppositional defiant disorder dimensions: genetic influences and risk for later psychopathology

Oppositional defiant disorder dimensions: genetic influences and risk for later psychopathology

Genetic associations with reflexive visual attention in infancy and childhood

MAOA Influences the Trajectory of Attentional Development

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