Oppositional defiant disorder dimensions: genetic influences and risk for later psychopathology

Mikolajewski, Amy J.; Taylor, Jeanette; Iacono, William G.

doi:10.1111/jcpp.12683

Cited by 33 publications

(19 citation statements)

References 39 publications

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“…Several studies demonstrate moderate genetic influences on irritability, with heritability estimates ranging from 31% to 54% across studies in the UK 17 , Sweden 18,19 and USA 20 . Moderate heritability estimates for defiant behavior, ranging from 41% to 45%, also have been reported in these studies, with moderate shared environmental influences as well.…”

Section: Introductionmentioning

confidence: 99%

External validation of a bifactor model of oppositional defiant disorder

et al. 2018

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Dimensions of irritability and defiant behavior, though correlated within the structure of ODD, convey separable developmental risks through adolescence and adulthood. Irritability predicts depression and anxiety, whereas defiant behavior is a precursor to antisocial outcomes. Previously we demonstrated that a bifactor model comprising irritability and defiant behavior dimensions, in addition to a general factor, provided the best fitting structure of ODD symptoms in five large datasets.1 Herein we extend our previous work by externally validating the bifactor model of ODD using multiple regression and multivariate behavior genetic analyses. We used parent ratings of DSM IV ODD symptoms, and symptom dimensions for ADHD (i.e., inattention and hyperactivity-impulsivity), Conduct Disorder (CD), Depression / Dysthymia, and Generalized Anxiety Disorder (GAD) from 846 6–18 year old twin pairs. We found that the ODD irritability factor was associated only with Depression / Dysthymia and GAD and the ODD defiant behavior factor was associated only with inattention, hyperactivity-impulsivity, and CD, whereas the ODD General factor was associated with all 5 symptom dimensions. Multivariate behavior genetic analyses found all 5 symptom dimensions shared genetic influences in common with the ODD General, irritability, and defiant behavior factors. In contrast, the defiant behavior factor shared genetic influences uniquely with inattention and hyperactivity-impulsivity, whereas the irritability factor shared genetic influences uniquely with Depression / Dysthymia and GAD, but not vice versa. This suggests that genes that influence irritability in early childhood also predispose to depression and anxiety in adolescence and adulthood. These multivariate genetic findings also support the external validity of the 3 ODD dimensions at the etiological level. Our study provides additional support for subtyping ODD based on these symptom dimensions, as in the revisions in the ICD-11, and suggests potential mechanisms underlying the development from ODD to behavioral or affective disorders.

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Section: Introductionmentioning

confidence: 99%

External validation of a bifactor model of oppositional defiant disorder

et al. 2018

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“… 18 This study derived a two-factor solution of ODD symptoms, namely, irritability and “headstrong” symptoms, and showed that irritability symptoms predicted anxiety disorders more strongly than headstrong symptoms (arguing with adults, defying adults’ requests). Another recent study conducted in twin pairs (n=1,225) by Mikolajewski et al 21 found consistent evidence of an “irritable” dimension predicting internalizing problems and a headstrong/hurtful dimension of substance-use disorder symptoms. Additionally, shared genetic risk between the dimension and the disorders was demonstrated.…”

Section: Nosology Of Oddmentioning

confidence: 86%

“…Shared environment was the weakest contributor. 21 A recent meta-analysis showed around 50% variance of CD comes from additive genetic effects. In this study, along with unshared environmental components, there was a significant shared environmental component, eg, parenting practices or neighborhood.…”

Section: Etiopathological Influencesmentioning

confidence: 99%

Oppositional defiant disorder: current insight

Ghosh¹,

Ray²,

Basu³

2017

PRBM

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Oppositional defiant disorder (ODD) is diagnosed broadly on the basis of frequent and persistent angry or irritable mood, argumentativeness/defiance, and vindictiveness. Since its inception in the third Diagnostic and Statistical Manual of Mental Disorders, epidemiological and longitudinal studies have strongly suggested a distinct existence of ODD that is different from other closely related externalizing disorders, with different course and outcome and possibly discrete subtypes. However, several issues, such as symptom threshold, dimensional versus categorical conceptualization, and sex-specific symptoms, are yet to be addressed. Although ODD was found to be highly heritable, no genetic polymorphism has been identified with confidence. There has been a definite genetic overlap with other externalizing disorders. Studies have begun to explore its epigenetics and gene–environment interaction. Neuroimaging findings converge to implicate various parts of the prefrontal cortex, amygdala, and insula. Alteration in cortisol levels has also been demonstrated consistently. Although a range of environmental factors, both familial and extrafamilial, have been studied in the past, current research has combined these with other biological parameters. Psychosocial treatment continues to be time-tested and effective. These include parental management training, school-based training, functional family therapy/brief strategic family therapy, and cognitive behavior therapy. Management of severe aggression and treatment of co-morbid disorders are indications for pharmacotherapy. In line with previous conceptualization of chronic irritability as a bipolar spectrum abnormality, most studies have explored antipsychotics and mood stabilizers in the management of aggression, with limited effects.

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“…According to the DSM-5 criteria, the diagnosis oppositional defiant disorder requires the presence of a specific pattern of a behavior which includes at least four out of 8 symptoms from any of the bellow listing categories that the child exhibits when interacting with at least one subject who is not a sibling (APA, 2013: 462): Recent research has shown that the oppositional defiant disorder might have two separate symptom dimensions: affective and behavioral. Based on these two phenomenologicallydistinct signs of the disorder, two types of oppositional defiant disorder have been distinguished: the one subtype is characterized by affective symptoms of irritability, temper tantrums, and resentful attitude, and the other subtype is characterized with the features of defiance like vindictiveness and arguing (Mikolajewski, Taylor & Iacono, 2017).…”

Section: Oppositional Defiant Disordermentioning

confidence: 99%

Family life satisfaction – Perception of the youth and their parents

Zloković¹,

Belaić²,

Čekolj³

2020

6th International E-Conference on Studies in Humanities and Social Sciences: Conference Proceedings

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Family satisfaction is significant and complex concept that includes personal satisfaction and relationship satisfaction among family members. The aim of this paper is to present and discuss the preliminary young people’s and their parents’ perception family satisfaction analysis. The research was conducted on a convenient sample of students/young people (N=50) and their parents (N=84). For the purposes of this research The Family Satisfaction Scale from FACES IV instrument (Olson, 2010) was used. The mentioned scale measures the positive aspects of relationship among the family members. The results indicate that young people and their parents are generally satisfied with their family life. On some items of the scale there is statistically significant difference among young people and their parents. Parents are more satisfied with their family life than their children. These results are encouraging especially in the context of COVID 19 pandemics and increasing numbers of undesirable family relationships.

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Oppositional defiant disorder dimensions: genetic influences and risk for later psychopathology

Cited by 33 publications

References 39 publications

External validation of a bifactor model of oppositional defiant disorder

External validation of a bifactor model of oppositional defiant disorder

Oppositional defiant disorder: current insight

Family life satisfaction – Perception of the youth and their parents

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