Dimerization of 3,4-Disubstituted Cinnamic Acids and Esters

Green and Efficient: Iron-Catalyzed Selective Oxidation of Olefins to Carbonyls with O2

“…However, when a cis/trans mixture of isoeugenol 5c was subjected to the reaction conditions, the dimeric γ-diisoeugenol was obtained quantitatively at a catalyst loading as low as 0.75 mol%. Although diisoeugenol dimers have attracted great interest in drug design, to the best of our knowledge, there are only a few methods for its selective preparation, with all requiring high catalysts loadings and/or toxic or hazardous reagents. , Thus, the iron-catalyzed dimerization appears to be an efficient and greener alternative for selectively synthesizing γ-diisoeugenol.…”

1-Ethyl-3-(4-hydroxy-3-methoxyphenyl)-6-methoxy-2-methylindan-5-ol

“…Products displaying anti-oxidant activity have acquired a great importance from the biological point of view, since they can show a series of activities ranging from the delay of cell deterioration to the inhibition of certain types of cancer (Liao et al, 2003). We stress the importance of our method of synthesis (described in the experimental section) because we have obtained a unique condensation product, in contrast to reported syntheses (Angle & Arnaiz, 1992;Al-Farhan et al, 1992;Alesso et al, 2003) for which mixtures of diastereoisomers were obtained.…”

Synthesis of 1-ethyl-2-methyl-3-arylindanes. Stereochemistry of five-membered ring formation

“…14 In this work, different pathways are described to obtain the natural asarone cyclodimer 2 and it is studied how the substitution pattern, in the aromatic rings of precursors, determines the steric course of cyclodimerisation.…”