Dimethoate-induced oxidative stress and DNA damage in Oncorhynchus mykiss

Evaluation of genotoxic and oxidative stress response to dimethoate in freshwater fish Channa punctatus (Bloch)

“…The DNA damage can be correlated with the clastogenecity of the mutagen because an increase in both micronuclei and DNA migration due to environmental mutagen has been reported in fish (Russo et al, 2004). There are few previous studies which showed dimethoate to be toxic particularly in fish (Dogan et al, 2011). Dimethoate belongs to the phosphorous ester group and is capable of phosphorylation and alkylation.…”

“…The mutagenic potential of dimethoate has been studied in fish and other aquatic organism (Dogan et al, 2011). Dimethoate poisoning is usually associated with neuromuscular transmission block in both animals and humans (Desi et al, 1998;Dongren et al, 1999).…”

Adverse Effect of Insecticides on Various Aspects of Fish’s Biology and Physiology

“…Genotoxic chemicals such as insecticides have common chemicals and physical properties that enable them interact with genetic materials (Campana et al, 1999;Çava & Ergene-Gözükara, 2003;Candioti et al, 2010;Dogan et al, 2011). The mutation that may result from an interaction between a chemical and the genetic material is a heritable change in the cell genotype, and thus the error may be transferred to the daughter cell or the next generation.…”

“…ROS can indiscriminately attack and react with susceptible vital macromolecules -lipids, proteins and DNA-in living cells, inducing cytotoxicity and can result in serious disturbances in physiological cell processes (Dogan et al, 2011;Jin et al, 2011). Lipid peroxidation, the major contributor to the loss of cell function, DNA damage, enzyme inactivation, and hormone oxidation are bio-indicators of oxidative cell damage and examples of toxic mechanisms of insecticide induced ROS being involved in pathological processes and in the etiology of many fish diseases (Üner et al, 2006;Dogan et al, 2011).…”

A new method for analysis of the toxicity of organophosphorus pesticide, dimethoate on rotifer based on response surface methodology

“…Extensive use of dimethoate and the subsequent release into environments may pose a series effect on non-target organisms and alter the balance of biological communities. As a broad used member of the OPs pesticides group, most aquatic toxicity tests of dimethoate have focused on fish [3,4], snail [5][6][7] and crab [2]. Studies on zooplankton are limited [8].…”