1995
DOI: 10.1002/mas.1280140204
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Dimethyl ether chemical ionization mass spectrometry

Abstract: The uses of dimethyl ether (DME) as an unusual positive ion reagent for chemical ionization mass spectrometry (CIMS) are reviewed. The fragment–molecule adducts formed by ion–molecule reactions of organic substrates with the ionized gas are highly characteristic for the substrates and frequently can be used to differentiate among isomers. The fragmentation mechanisms of the adducts have been studied by collision‐induced dissociation and with deuterium labeling, and, in some cases, are well‐understood. DME CIMS… Show more

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Cited by 24 publications
(10 citation statements)
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“…Since then, in the past 5È6 years DME has been extensively used for the characterization of a variety of classes of organic compounds, and was the topic of a recent review. 13 IonÈmolecule reactions of DME gave rise to fragmentÈ molecule adducts which were especially useful in di †er-entiation among isomeric substituted aromatics.14h18 DME CIMS has further been applied to such diverse biologically important or environmentally signiÐcant classes of compounds as benzodiazepines,19 cinchona alkaloids,20 trichothecene biotoxins,21 nucleic acid bases and nucleosides,22 nucleoside antibiotics,23 nitramine munitions18,24 and polynuclear aromatic hydrocarbons. 25 A rationale for the application of DME CIMS to individual amino acids was suggested by the ongoing work of OÏHair and co-workers in which the gas-phase reactions of the simplest amino acid, glycine, with a variety of electrophiles including the dimethylchloronium ion and the methoxymethylene (CH 3 ) 2 Clc ation were studied.…”
Section: Introductionmentioning
confidence: 99%
“…Since then, in the past 5È6 years DME has been extensively used for the characterization of a variety of classes of organic compounds, and was the topic of a recent review. 13 IonÈmolecule reactions of DME gave rise to fragmentÈ molecule adducts which were especially useful in di †er-entiation among isomeric substituted aromatics.14h18 DME CIMS has further been applied to such diverse biologically important or environmentally signiÐcant classes of compounds as benzodiazepines,19 cinchona alkaloids,20 trichothecene biotoxins,21 nucleic acid bases and nucleosides,22 nucleoside antibiotics,23 nitramine munitions18,24 and polynuclear aromatic hydrocarbons. 25 A rationale for the application of DME CIMS to individual amino acids was suggested by the ongoing work of OÏHair and co-workers in which the gas-phase reactions of the simplest amino acid, glycine, with a variety of electrophiles including the dimethylchloronium ion and the methoxymethylene (CH 3 ) 2 Clc ation were studied.…”
Section: Introductionmentioning
confidence: 99%
“…The structure of the four isomers is very similar therefore their proton affinity is probably close. Their positive chemical ionization mass spectra with ammonia 1,2 were also identical: MH is the base peak and MNH 4 has an intensity of 5%. When tandem mass spectrometry analysis were conducted on the M Á ion, exocyclic diastereoisomers could be distinguished from endocyclic isomers, but not (À)-alloaromadendrene from ()-aromadendrene as expected.…”
Section: Resultsmentioning
confidence: 93%
“…The relative intensity of the abstraction [M À H] ion, with DME as reagent gas, allows us to clearly distinguish between three isomers, alloaromadendrene (1), aromadendrene (2) and ledene (4).…”
Section: Discussionmentioning
confidence: 99%
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“…[12][13][14][15][16][17][18][19][20][21][22] A review describing the use of dimethyl ether as a reagent for chemical ionization (CI) has also been published. 23 The present work describes the ion/molecule reactions of the CH 3 OCH 2 ion with the group of arylalkylamines shown in Table 1, which include a group of biologically important molecules (biogenic amines). This study is focused first on the analysis of the CI mass spectra in terms of the relative …”
mentioning
confidence: 99%