Dimethylarsinic acid: Results of chronic toxicity/oncogenicity studies in F344 rats and in B6C3F1 mice

Arnold, Lora L.; Eldan, Michal; Nyska, Abraham; Gemert, Marcia van; Cohen, Samuel M.

doi:10.1016/j.tox.2006.03.013

Cited by 75 publications

(101 citation statements)

References 36 publications

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“…Rat, mouse and dog Arnold et al (1999Arnold et al ( , 2003Arnold et al ( , 2006; Cohen et al (2001); Waner and Nyska (1988); Wei et al (1999Wei et al ( , 2002 Body weight, developmental and reproductive effects Decreased body weight, decreased fetal weight, increased fetal incidence of incomplete ossification and malformation and reduced fertility…”

Section: Hematological Effectsmentioning

confidence: 99%

“…Respiratory arrest and decreased lung ornithine decarboxilase activity Mouse Ahmad et al (1999); Kaise et al (1989) Endocrine effects Hypertrophy of thyroid follicle epithelium Rat Arnold et al (2006); Crown et al (1987); Rubin et al (1989) …”

Section: Respiratory Effectsmentioning

confidence: 99%

“…Decreased spontaneous motility, increased startle response and ataxia Mouse Kaise et al (1989) Cancer Bladder tumors, lung adenoma or carcinoma Rat and mouse Arnold et al (2006); Hayashi et al (1998);Wei et al (1999Wei et al ( , 2002) Genotoxicity DNA single-stand breaks in lung, DNA adduct formation Rat and mouse Yamanaka et al (1989Yamanaka et al ( , 1993Yamanaka et al ( , 2001; Yamanaka and Okada (1994) Inhalation exposure (inorganic arsenic, mainly arsenic trioxide dust) Respiratory effects Respiratory irritant effects Humans Dunlap (1921); Morton and Caron (1989); Pinto and Mcgill (1953) …”

Section: Neurological Effectsmentioning

confidence: 99%

See 2 more Smart Citations

A review on exposure and effects of arsenic in passerine birds

Sánchez‐Virosta

Espín

García-Fernández

et al. 2015

Science of The Total Environment

109

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Section: Hematological Effectsmentioning

confidence: 99%

Section: Respiratory Effectsmentioning

confidence: 99%

Section: Neurological Effectsmentioning

confidence: 99%

See 1 more Smart Citation

A review on exposure and effects of arsenic in passerine birds

Sánchez‐Virosta

Espín

García-Fernández

et al. 2015

Science of The Total Environment

109

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“…F344 rats are the only identified laboratory animals that develop urinary bladder transitional cell carcinoma from arsenic in drinking water [Wei et al, 2002] or diet [Arnold et al, 2006]. Females were chosen because their urinary bladders are more susceptible to arsenic toxicity than males [Arnold et al, 1999;Shen et al, 2006].…”

Section: Animals and Animal Carementioning

confidence: 99%

“…Animals were treated via drinking water for 7 days with either 100 ppm DMA(V) [Groups A through D], or 100 ppm As(V) [Group I ]. The concentration of DMA(V) was chosen because of the increase in bladder transitional cell carcinoma in rats exposed to 100 ppm DMA(V) in 2 year exposure studies [Wei et al, 1999;Arnold et al, 2006], and the As(V) concentration was chosen to provide comparison to DMA(V) exposure. A single oral gavage of CP (11.75 mg CP/kg BW, equivalent to 1/8 LD 50 ) was given at the end of 7-day exposure to DMA(V), and animals were allowed to recover for either 1 day [Group A] or 5 days [Group B] before the terminal surgery to collect urinary bladder cells and bone marrow.…”

Section: Animals and Animal Carementioning

confidence: 99%

Arsenate and dimethylarsinic acid in drinking water did not affect DNA damage repair in urinary bladder transitional cells or micronuclei in bone marrow

Wang

Kligerman

Holladay

et al. 2009

Environ and Mol Mutagen

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Arsenic is a human skin, lung, and urinary bladder carcinogen, and may act as a cocarcinogen in the skin and urinary bladder. Possible modes of action of arsenic carcinogenesis/cocarcinogenesis include oxidative stress induction and inhibition of DNA damage repair. We investigated the effects of arsenic in drinking water on DNA damage repair in urinary bladder transitional cells and on micronucleus formation in bone marrow. F344 rats were given 100 ppm arsenate [As(V)] or dimethylarsinic acid [DMA(V)] in drinking water for 1 week. The in vivo repair of cyclophosphamide (CP)-induced DNA damage resulting from a single oral gavage of CP, and the in vitro repair of hydrogen peroxide (H(2)O(2))- or formaldehyde-induced DNA damage, resulting from adding H(2)O(2) or formaldehyde into cell medium, were measured by the Comet assay. DMA(V) effects were not observed on either CP-induced DNA damage induction or on DNA repair. Neither DMA(V) nor As(V) increased the H(2)O(2)- or formaldehyde-induced DNA damage, and neither inhibited the repair of H(2)O(2)-induced DNA damage. Neither DMA(V) nor As(V) increased the micronucleus frequency, nor did they elevate micronucleus frequency resulting from CP treatment above the level observed by the treatment with CP alone. These results suggest that arsenic carcinogenesis/cocarcinogenesis in the urinary bladder may not be via DNA damage repair inhibition. To our knowledge this is the first report of arsenic effects on DNA damage repair in the urinary bladder.

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Methylarsenverbindungen [MAK Value Documentation in German language, 2014]

2014

The MAK‐Collection for Occupational Health and Safety

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Dimethylarsinic acid: Results of chronic toxicity/oncogenicity studies in F344 rats and in B6C3F1 mice

Cited by 75 publications

References 36 publications

A review on exposure and effects of arsenic in passerine birds

A review on exposure and effects of arsenic in passerine birds

Arsenate and dimethylarsinic acid in drinking water did not affect DNA damage repair in urinary bladder transitional cells or micronuclei in bone marrow

Methylarsenverbindungen [MAK Value Documentation in German language, 2014]

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