Dimethylsulphoxide in Amyloidosis

Oral dimethyl sulfoxide for systemic amyloid A amyloidosis complication in chronic inflammatory disease: a retrospective patient chart review

“…Previous reports and our own experience have suggested that this drug may be advocated for patients with amyloid A amyloidosis. 5,8,14 However, all our patients were concomitantly treated with corticosteroids and other antiinflammatory drugs. A potentiation effect of DMSO on conventional treatments may therefore be postulated.…”

A Case of Pulmonary Amyloidosis Associated with Multiple Myeloma Successfully Treated with Dimethyl Sulfoxide

“…Single doses of this drug in human subjects have resulted in transient excretion of Congo philic, amyloid-like fibrils in the urine. These urinary fi brils may be fragments of amyloid-fibrillar subunits dis lodged from renal amyloid deposits [16], The use of DMSO is still experimental, but it has been reported to have clinical value [8][9][10]. Three scries of patients with amyloidosis treated with DMSO have thus far been re- 92 Iwasaki/Hamano/Aizawa/Kobayashi/ Kakishita Dimethyl Sulfoxide Therapy ported.…”

“…A potentiation of melphalan effect by DMSO could be postulated, so that these results cannot be interpreted as demonstrating an unequivocal therapeutic effect of DMSO on myeloma-as sociated amyloidosis. Two patients with amyloidosis sec ondary to rheumatoid arthritis were included in the scries reported by van Rijswijk et al [9], but the results of DMSO were inconclusive. The patients who responded to DMSO in that series were only 3 with amyloidosis secondary to rheumatoid arthritis.…”

“…Dimethyl sulfoxide (DMSO), an industrial solvent first introduced into treatment of amy loidosis by Isobe and Osserman [5], causes partial or total disappearance of experimentally induced amyloid depos its in mice [5][6][7]. Therapeutic trials on a small number of patients indicated that prolonged treatment with this agent may be effective in certain types of systemic amyloi dosis [8][9][10]. We present a case of multiple myeloma com plicated by systemic amyloidosis.…”

Anti-Amyloid Drugs

“…Dimethyl sulphoxide (DMSO) was claimed a decade ago to be effective in 'solubilising' amyloid fibrils) [52][53][54] The early promise of this compound was not fulfilled. The original observations claiming direct dissolution of amyloid by DMSO could not be repeated, and patients given DMSO for prolonged periods of time developed a body odour which proved socially unacceptable.…”