Diminished ovarian reserve in Behçet’s disease patients

Mont'Alverne, A.R.S.; Yamakami, Lucas Yugo Shiguehara; Gonçalves, Célio Roberto; Baracat, Edmund Chada; Bonfá, Eloísa; Silva, Clóvis A.

doi:10.1007/s10067-014-2680-5

Cited by 31 publications

(16 citation statements)

References 22 publications

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“…Both methods may be used in the ovarian reserve assessment [24]. The comparable results obtained herein and in accordance to other studies in autoimmune rheumatic diseases with high positive correlation between the two AMH assays [6,23,25,26] minimized the instability in terms of AMH Gen II ELISA values reported previously [27].…”

Section: Discussionsupporting

confidence: 92%

Reduced ovarian reserve in patients with adult polymyositis

et al. 2015

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Polymyositis (PM) affects female gender during reproductive age; however, there is no study assessing ovarian reserve in these patients to evaluate ovarian reserve markers in PM. Eight female patients with PM (Bohan and Peter criteria, 1975) with aged 18-40 years, followed at our tertiary centre from March 2011 to May 2014, were invited to participate. They were age-matched with 16 healthy individuals (control group). All were evaluated at early follicular phase of menstrual cycle. Follicle stimulating hormone (FSH), estradiol, inhibin B, anti-Müllerian hormone (AMH) serum levels (ELISA) and sonographic antral follicle count (AFC) were determined. PM patients and controls had comparable mean age (31.4 ± 6.5 vs. 30.7 ± 6.2 years, P = 0.946), ethnicity and socioeconomic class (P > 0.05). PM mean age of onset was 27.3 ± 6.5 years and disease duration of 6.5 ± 4.1 years. Menstrual cycles were alike in both groups with a similar frequency of age at menarche, gynaecological age, duration and length of menstrual cycle (P > 0.05). The median serum level of AMH was significantly lower in PM compared to controls [0.7(0.3-3.4) vs. 3.1(1.4-4.0), P = 0.021]. AMH levels ≤1 ng/mL (50 vs. 6.3 %, P = 0.024) and very low AFC (37.5 vs. 6.3 %, P = 0.037) were significantly in PM patients versus controls. The other hormones (FSH, inhibin B and estradiol levels) were similar between both groups (P > 0.05). The present study was the first to identify subclinical ovarian dysfunction in PM patients during reproductive ages. Further study is necessary to assess the possible role of PM-related factors that may influence the ovarian function of these patients.

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Section: Discussionsupporting

confidence: 92%

Reduced ovarian reserve in patients with adult polymyositis

et al. 2015

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“…We did not detect any difference between ovarian volumes of BD patients and controls like Cil et al (18) and Mont'Alverne et al (4). There are several limitations in our study.…”

Section: Original Papercontrasting

confidence: 54%

“…Apart from genital aphthous ulcers, BD can cause ovarian vein thrombosis (2), placental necrotizing vasculitis, decidual villitis (3), and diminished ovarian reserve (4) in the female reproductive system. BD may have an impact on the female reproductive vasculature since BD vasculitis can also affect arteries or veins (5).…”

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confidence: 99%

Color Doppler analysis of female reproductive vasculature in Behçet’s disease

et al. 2016

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summaryBehçet's disease (BD) may affect female reproductive vasculature. We aimed to evaluate Doppler sonographic characteristics of female reproductive vasculature and also ovarian volume, endometrial thickness (EMT) and antral follicle count of BD patients in comparison with a healthy control group. Seventeen premenopausal women aged between 18-45 years with BD, and a control group of 31 age-and body mass index-matched healthy women was included in the study. Uterine, spiral and intraovarian artery blood flow were examined by Doppler sonography in the late follicular phase. Resistance index, pulsatility index and systolic/diastolic ratio were recorded together with ovarian volume, EMT and antral follicle count. In particular this is a pilot study including the evaluation of the spiral and uterine arteries in BD. Doppler sonographic parameters, ovarian volume, EMT and antral follicle count of BD patients and healthy controls were not found to be statistically different. As a result of our analysis, we found similar Doppler sonographic features of both BD patients and the control group. Further studies conducted on a larger sample population with more aggressive BD symptoms may reveal the actual effect of BD on the female reproductive system.

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“…There are a few studies in the literature about the role of AMH levels in evaluating ovarian reserves in rheumatic diseases. Mont'Alverne et al evaluated AMH levels and ovarian reserves in 10 patients with Behçet's disease and in 22 healthy controls [ 17 ]. In that study, AMH levels were markedly lower in patients with Behçet's disease (BD), whereas FSH levels were higher [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Ovarian Reserve with Anti-Müllerian Hormone in Familial Mediterranean Fever

Şahin

Karakuş

Durmaz

et al. 2015

International Journal of Rheumatology

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Objective. To investigate ovarian reserves in attack-free familial Mediterranean fever (AF-FMF) patients at the reproductive age by anti-Müllerian hormone (AMH), antral follicle count (AFC), ovarian volume, and hormonal parameters. Methods. Thirty-three AF-FMF patients aging 18–45 years and 34 healthy women were enrolled and FSH, LH, E2, PRL, and AMH levels were measured in the morning blood samples at 2nd–4th days of menstruation by ELISA. Concomitant pelvic ultrasonography was performed to calculate AFC and ovarian volumes. Results. In FMF patient group, median AMH levels were statistically significantly lower in the M69V mutation positive group than in the negative ones (P = 0.018). There was no statistically significant difference in median AMH levels between E148Q mutation positive patients and the negative ones (P = 0.920). There was also no statistically significant difference in median AMH levels between M680I mutation positive patients and the negative ones (P = 0.868). No statistically significant difference was observed in median AMH levels between patients who had at least one mutation and those with no mutations (P = 0.868). We realized that there was no difference in comparisons between ovarian volumes, number of follicles, and AMH levels ovarian reserves when compared with FMF patients and healthy individuals. Conclusions. Ovarian reserves of FMF pateints were similar to those of healthy subjects according to AMH. However, AMH levels were lower in FMF patients with M694V mutation.

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Diminished ovarian reserve in Behçet’s disease patients

Cited by 31 publications

References 22 publications

Reduced ovarian reserve in patients with adult polymyositis

Reduced ovarian reserve in patients with adult polymyositis

Color Doppler analysis of female reproductive vasculature in Behçet’s disease

Evaluation of Ovarian Reserve with Anti-Müllerian Hormone in Familial Mediterranean Fever

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