Diminished ovarian reserve is associated with reduced euploid rates via preimplantation genetic testing for aneuploidy independently from age: evidence for concomitant reduction in oocyte quality with quantity

Jaswa, Eleni Greenwood; McCulloch, Charles E.; Simbulan, Rhodel; Cedars, Marcelle I.; Rosen, Mitchell P.

doi:10.1016/j.fertnstert.2020.10.051

Cited by 54 publications

(43 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such evidence comes from a recent study examining whether serum AMH predicts CLBR in women with DOR independent of age (2). It addresses the question posed by Jaswa et al (1) and supports a similar conclusion to the PGT-A model. Higher CLBRs in women with DOR are noted with higher AMH values independent of age, indirectly supporting the concept of a greater percent-age of euploid embryos resulting in a greater CLBR per cycle start.…”

supporting

confidence: 66%

“…Furthermore, although there were no observed differences in miscarriage rates based on DOR reported in the Jaswa et al study (1), there are reports of an inverse correlation between AMH and risk of miscarriage in women attempting natural conception (3) and those undergoing ART, independent of age (4). These data further support the concept that there is both a reduction in quantity and quality of oocytes and resultant embryos present in women with DOR as assessed by AMH independent of age.…”

supporting

confidence: 56%

“…As previously mentioned, although the study by Jaswa et al (1) did not examine the correlation between PGT-A euploidy embryos and AMH, such studies have been attempted in the past but have had limited sample size and used early developed and less consistent assay methods (5). If a strong correlation were demonstrated between euploidy embryos and a contemporary automated AMH assay, this would offer a practical approach to predict the number of expected euploid embryos obtained by PGT-A before starting a given cycle.…”

mentioning

confidence: 85%

“…Jaswa et al (1) present their extensive preimplantation genetic testing for euploidy (PGT-A) experience between 2010 and 2019. In >1,150 women aged 19-42 with 8,000 biopsied blastocysts, the authors compare euploidy rates in women with or without diminished ovarian reserve (DOR).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Connecting the dots between oocyte quantity and quality in diminished ovarian reserve

Seifer

2021

Fertility and Sterility

View full text Add to dashboard Cite

supporting

confidence: 66%

supporting

confidence: 56%

mentioning

confidence: 85%

mentioning

confidence: 99%

See 2 more Smart Citations

Connecting the dots between oocyte quantity and quality in diminished ovarian reserve

Seifer

2021

Fertility and Sterility

View full text Add to dashboard Cite

“…Ovarian reserve decreases with age and is often linked to oocyte quantity and quality [ 26 ]. Notably, however, oocyte quantity can also be used as an independent predictor of oocyte quality and live-birth rate.…”

Section: Introductionmentioning

confidence: 99%

VEGF Concentration in a Preovulatory Leading Follicle Relates to Ovarian Reserve and Oocyte Maturation during Ovarian Stimulation with GnRH Antagonist Protocol in In Vitro Fertilization Cycle

Chen

Lin

et al. 2021

JCM

View full text Add to dashboard Cite

Serum vascular endothelial growth factor (VEGF) is involved in follicular vascularization, oxygenation, and consequently in oocyte maturation and embryo development. Unanswered questions remain regarding the relationship of intrafollicular VEGF level in preovulatory leading follicles to oocyte maturation and ovarian reserve during ovarian stimulation. We conducted this study to investigate the relationship of intrafollicular VEGF level in the fluid of single preovulatory leading follicles to ovarian reserve and oocyte maturation in patients receiving GnRH antagonist in vitro fertilization (IVF) protocol treatment. One hundred and eighty-five patients receiving IVF treatment were recruited and assigned to low-, normal-, and high-ovarian-reserve groups according to their serum anti-Müllerian hormone (AMH) level. Follicular fluid (FF) in preovulatory leading follicles, serum profiles, and clinical variables were collected for analysis. The result disclosed a significant among-group difference in FF VEGF concentration. Moreover, the serum AMH level was also negatively correlated with FF VEGF level. The oocyte maturation rate tended to be increased at higher AMH levels. FF VEGF concentration was significantly positively correlated with basal FSH level. In conclusion, FF VEGF concentration has a negative association with ovarian reserve level and oocyte maturation rate in patients undergoing GnRH antagonist IVF protocols.

show abstract

Evaluating the efficacy of ovulation stimulation with intrauterine insemination in women with diminished ovarian reserve compared to women with normal ovarian reserve

Kaleli

Kervancıoğlu

Erol

et al. 2022

Intl J Gynecology & Obste

View full text Add to dashboard Cite

Objective To assess the efficacy of ovulation induction and intrauterine insemination (IUI) in couples with diminished ovarian reserve (DOR). Methods Women aged 20–39 years and men younger than 50 years were included. Four “ovarian reserve groups” were created according to anti‐Müllerian hormone (AMH) and the partner's age. Gestational sac finding on ultrasound examination was the primary outcome measure. Results The study was carried out on a total of 770 cycles of 362 women in an infertility cohort that consisted of 75 women with DOR treated by 153 cycles and 287 women without DOR treated by 617 cycles. The pregnancy rate was similar in the four ovarian reserve groups in terms of first, second, third plus fourth, and total attempts of IUI cycles. Moreover, the pregnancy rate, miscarriage rate, and multiple pregnancy rate were similar. We found no difference in the cumulative pregnancy rate among the groups after four IUI cycles. Multivariate logistic regression analysis of the entire cohort revealed that infertility duration, post‐wash sperm count, and follicle number greater than 11 mm on the day of human chorionic gonadotropin trigger were independent predictors of pregnancy (P < 0.001). Neither age nor AMH predicted pregnancy after ovulation stimulation and IUI. Conclusions Ovulation stimulation and IUI are equally effective in women with DOR and in women with normal ovarian reserve in terms of pregnancy rate, multiple pregnancy rate, and miscarriage rate per IUI cycle or cumulative pregnancy rate after four cycles of IUI.

show abstract

Diminished ovarian reserve is associated with reduced euploid rates via preimplantation genetic testing for aneuploidy independently from age: evidence for concomitant reduction in oocyte quality with quantity

Cited by 54 publications

References 26 publications

Connecting the dots between oocyte quantity and quality in diminished ovarian reserve

Connecting the dots between oocyte quantity and quality in diminished ovarian reserve

VEGF Concentration in a Preovulatory Leading Follicle Relates to Ovarian Reserve and Oocyte Maturation during Ovarian Stimulation with GnRH Antagonist Protocol in In Vitro Fertilization Cycle

Evaluating the efficacy of ovulation stimulation with intrauterine insemination in women with diminished ovarian reserve compared to women with normal ovarian reserve

Contact Info

Product

Resources

About