Diminished Quality of Life and Increased Brain Functional Connectivity in Patients with Hypothyroidism After Total Thyroidectomy

Abstract

Local brain FC is increased in the acute hypothyroid state. Higher FC correlates with a poorer mental QoL and increased depression in the hypothyroid state.

Quality of Life and Cost-Effectiveness of Radiofrequency Ablation versus Open Surgery for Benign Thyroid Nodules: a retrospective cohort study

“…Moreover, patients following thyroid surgery have a high frequency of hypothyroidism and neck scar complaints, which adversely affects the health-related quality of life (HRQoL)4. To reduce these side effects, recently various nonsurgical minimally invasive techniques have been introduced—radiofrequency ablation (RFA) being just one of them5.…”

Is it time to reconsider lobectomy in low‐risk paediatric thyroid cancer?

“…Thyroid lobectomy is associated with a lower risk of surgical complications including recurrent laryngeal nerve palsy and (transient) hypoparathyroidism . Moreover, most patients who undergo less‐than‐total thyroidectomy retain autonomous thyroid function, making it easier to achieve a euthyroid state in these patients and potentially avoiding negative impact on quality of life associated with total thyroidectomy and lifelong thyroid replacement . Nonetheless, a subset of children undergoing lobectomy may still require levothyroxine treatment to achieve adequate TSH suppression.…”

“…4,10 Moreover, most patients who undergo less-than-total thyroidectomy retain autonomous thyroid function, making it easier to achieve a euthyroid state in these patients 15 and potentially avoiding negative impact on quality of life associated with total thyroidectomy and lifelong thyroid replacement. [16][17][18] Nonetheless, a subset of children undergoing lobectomy may still require levothyroxine treatment to achieve adequate TSH suppression. We readily acknowledge that these data do not specifically address the outcomes that formed the basis for the ATA recommendation for total thyroidectomy, specifically: recurrence and survival in low-risk children.…”

Low fT3 is associated with diminished health-related quality of life in patients with acute coronary syndrome treated with drug-eluting stent: a longitudinal observational study

“…In addition, thyroid hormones are essential in the nervous system development of the human brain [ 36 ]. A lack of thyroid hormones during human brain development could lead to irreversible mental retardation and neurological deficits [ 37 ], thus lead to diminished mental quality of life [ 38 ]. The sensitivity of brain to fluctuation in the thyroid hormone concentration might also be responsible for depression in patients with CAD [ 39 ].…”