Diminished response to pleasant stimuli by depressed women.

Sloan, Denise M.; Strauss, Milton E.; Wisner, Katherine L.

doi:10.1037/0021-843x.110.3.488

Cited by 195 publications

(210 citation statements)

References 28 publications

(32 reference statements)

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“…The findings emerging from the present study are consistent with and extend prior reports in depression of reduced reactivity to pleasant cues (e.g., Sloan et al, 2001;Suslow et al, 2001), blunted reward responsiveness (e.g., Henriques and Davidson, 2000), and diminished attentional positivity bias (e.g., McCabe and Gotlib, 1995;Wang et al, 2006). Unlike prior studies, however, the current work provides initial evidence that clinically depressed subjects show a diminished propensity to modulate behavior as a function of reinforcement history, particularly in the absence of immediate reinforcement.…”

Section: Discussionsupporting

confidence: 92%

“…Interestingly, resting activity within left prefrontal regions has been linked to individuals' propensity to respond to rewardrelated cues , providing convergent evidence that depressed subjects might display reduced hedonic capacity. Finally, studies employing various paradigms have shown that depressed subjects display a blunted emotional response to pleasant cues (e.g., Sloan et al, 2001;Suslow et al, 2001), decreased reward responsiveness (e.g., Henriques and Davidson, 2000), a lack of a positivity bias in attentional tasks (e.g., McCabe and Gotlib, 1995;Wang et al, 2006), and dysfunctions within the brain reward system (e.g., Keedwell et al, 2005;Tremblay et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…To this end, we computed the probability of specific responses (e.g., selecting the more frequently rewarded response) as a function of the immediately preceding trial (e.g., which stimulus was rewarded in the preceding trial). Unlike prior studies (e.g., Henriques and Davidson, 2000;Sloan et al, 2001;Suslow et al, 2001), this approach allowed us to evaluate whether blunted hedonic capacity in depression is due to reduced responsiveness to single rewards, or more generally, reduced ability to integrate reinforcement history over time. The third and final goal was to test the hypothesis that reduced hedonic capacity would be most pronounced in MDD subjects reporting elevated anhedonic symptoms in their daily life.…”

Section: Introductionmentioning

confidence: 99%

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Reduced hedonic capacity in major depressive disorder: Evidence from a probabilistic reward task

Pizzagalli

Iosifescu

Hallett

et al. 2008

Journal of Psychiatric Research

664

693

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Objective-Anhedonia, the lack of reactivity to pleasurable stimuli, is a cardinal feature of depression that has received renewed interest as a potential endophenotype of this debilitating disease. The goal of the present study was to test the hypothesis that individuals with major depression are characterized by blunted reward responsiveness, particularly when anhedonic symptoms are prominent.Methods-A probabilistic reward task rooted within signal-detection theory was utilized to objectively assess hedonic capacity in 23 unmedicated subjects meeting DSM-IV criteria for major depressive disorder (MDD) and 25 matched control subjects recruited from the community. Hedonic capacity was defined as reward responsiveness -i.e., the participants' propensity to modulate behavior as a function of reward.Results-Compared to controls, MDD subjects showed significantly reduced reward responsiveness. Trial-by-trial probability analyses revealed that MDD subjects, while responsive to delivery of single rewards, were impaired at integrating reinforcement history over time and expressing a response bias toward a more frequently rewarded cue in the absence of immediate reward. This selective impairment correlated with self-reported anhedonic symptoms, even after considering anxiety symptoms and general distress.Conclusions-These findings indicate that MDD is characterized by an impaired tendency to modulate behavior as a function of prior reinforcements, and provides initial clues about which aspects of hedonic processing might be dysfunctional in depression.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Reduced hedonic capacity in major depressive disorder: Evidence from a probabilistic reward task

Pizzagalli

Iosifescu

Hallett

et al. 2008

Journal of Psychiatric Research

664

693

View full text Add to dashboard Cite

show abstract

“…However, in comparison to nondepressed participants, individuals with clinical and subclinical depression do not show an increased activity of the zygomaticus major muscle in response to happy expressions (Sloan et al, 2002), pleasant images (Sloan et al, 2001), and happy imagery (Schwartz et al, 1976). Based on these findings, we expect that there are normal affective responses to negative events but reduced affective responses to positive events in depression.…”

Section: Reward and Punishment Consumption From A Facial Expressions mentioning

confidence: 80%

“…The few studies that focus on facial EMG activity in depression demonstrate that individuals with clinical and subclinical depression respond with increased activity of the corrugator supercilii muscle to unhappy expressions (Sloan, Bradley, Dimoulas, & Lang, 2002), unpleasant images (Sloan, Strauss, & Wisner, 2001), and sad imagery (Schwartz, Fair, Salt, Mandel, & Klerman, 1976), just as do nondepressed control participants. However, in comparison to nondepressed participants, individuals with clinical and subclinical depression do not show an increased activity of the zygomaticus major muscle in response to happy expressions (Sloan et al, 2002), pleasant images (Sloan et al, 2001), and happy imagery (Schwartz et al, 1976).…”

Section: Reward and Punishment Consumption From A Facial Expressions mentioning

confidence: 99%

Wanting and liking in dysphoria: Cardiovascular and facial EMG responses during incentive processing

Franzén

Brinkmann

2016

Biological Psychology

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Theories and research on depression point to reduced responsiveness during reward anticipation and in part also during punishment anticipation. They also suggest weaker affective responses to reward consumption and unchanged affective responses to punishment consumption. However, studies investigating incentive anticipation using effort mobilization and incentive consumption using facial expressions are scarce. The present studies tested reward and punishment responsiveness in a subclinically depressed sample, manipulating a monetary reward (Study 1) and a monetary punishment (Study 2). Effort mobilization was operationalized as cardiovascular reactivity, while facial expressions were measured by facial electromyographic reactivity. Compared to nondysphorics, dysphorics showed reduced preejection period (PEP) reactivity and blunted self-reported wanting during reward anticipation but reduced PEP reactivity and normal self-reported wanting during punishment anticipation.Compared to nondysphorics, dysphorics showed reduced zygomaticus major muscle reactivity and blunted self-reported liking during reward consumption but normal corrugator supercilii muscle reactivity and normal self-reported disliking during punishment consumption.

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Neural Processing of Reward and Loss in Girls at Risk for Major Depression

Gotlib¹,

Hamilton²,

Cooney³

et al. 2010

Arch Gen Psychiatry

308

237

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Context Deficits in reward processing and their neural correlates have been associated with major depression. It is unclear, however, if these deficits precede the onset of depression or are a consequence of this disorder. Objective To determine whether anomalous neural processing of reward characterizes children at familial risk for depression in the absence of a personal history of psychopathology. Design Comparing neural activity of children at low and high risk for depression as they process reward and loss. Setting University fMRI facility. Participants Thirteen 10– 14-year-old never-disordered daughters of mothers with recurrent depression (“high risk”) and 13 age-matched never-disordered daughters with no family history of depression (“low risk”). Main Outcome Measure Neural activity, as measured with fMRI, in key reward and attention neural circuitry during anticipation and receipt of reward and loss. Results While anticipating gains, high-risk participants showed less activation than did their low-risk counterparts in the putamen and left insula, but greater activation in the right insula. When receiving punishment, high-risk participants showed greater activation in the dorsal anterior cingulate gyrus than did low-risk participants, who showed greater activation in the caudate and putamen. Conclusions Familial risk for depression affects neural mechanisms underlying the processing of reward and loss; young girls at risk for depression exhibit anomalies in the processing of reward and loss prior to the onset of depressive symptoms. Longitudinal studies are needed to examine whether these characteristics predict the subsequent onset of depression.

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Diminished response to pleasant stimuli by depressed women.

Cited by 195 publications

References 28 publications

Reduced hedonic capacity in major depressive disorder: Evidence from a probabilistic reward task

Reduced hedonic capacity in major depressive disorder: Evidence from a probabilistic reward task

Wanting and liking in dysphoria: Cardiovascular and facial EMG responses during incentive processing

Neural Processing of Reward and Loss in Girls at Risk for Major Depression

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