Dinitrosyl-iron triggers apoptosis in Jurkat cells despite overexpression of Bcl-2

Kleschyov, Andrei L.; Strand, Susanne; Schmitt, Steffen; Gottfried, Daniela; Skatchkov, M.; Sjakste, Nikolajs; Daiber, Andreas; Umansky, Victor; Münzel, Thomas

doi:10.1016/j.freeradbiomed.2005.12.001

Cited by 69 publications

(60 citation statements)

References 49 publications

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“…This, in its turn, stimulates the appearance in the cell environment, of significant amounts of NO and NO + , which initiate death of tumor cells. Aforementioned results obtained by our German colleagues who observed death of human leukaemia cells initiated by DNIC with thiosulfate [44] provide additional support in favor of validity of our hypothesis.…”

Section: Number Of Channelsupporting

confidence: 76%

“…By interacting with DNIC, iron chelators initiated their decomposition with a concomitant release of NО and NO + in amounts sufficient to exert toxic effects on rapidly proliferating cells. Such a scenario might have taken place in the studies by a group of German investigators who examined the proapoptotic effect of DNIC with thiosulfate on human Jurkat leukemia cells [44]. In our investigations we established that DNIC with glutathione exert a similar cytotoxic effect on an endometriosis model in rats [45].…”

Section: Introductionsupporting

confidence: 58%

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In-Vitro Antibacterial Activity of Processed Moringa Oleifera Seed Extract: Kill-Time Study

Idris¹,

Muyibi²,

Jamal³

et al. 2013

TOPROCJ

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Some present-day concepts of biological activities of dinitrosyl iron complexes (DNIC) with thiol-containing ligands are reviewed. These activities are determined by the ability of DNIC to act as donors of NO and nitrosonium ions (NO + ) in various body cells and tissues. DNIC are endowed with strong vasodilator activity. Due to the latter DNIC single dose injection into animal and human organisms induces long-lasting hypotension. Moreover, DNIC suppress platelet aggregation, increase red blood cell elasticity, accelerate skin wound healing, induce penis erection in animals and exert pronounced anti-apoptotic effect on cultured non-tumor cells. These regulatory effects are due to the slow release of NO and NO + from intact DNIC at both organism and in cell cultures. Fast decomposition of DNIC, e.g., in the presence of exogenous or endogenous iron-chelating agents, results in a toxic effect of DNIC on various cells and tissues and causes apoptosis of, e.g., HeLa and Jurkat human tumor cells. More recent model studies established the ability of DNIC to suppress endometriosis in rats.

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Section: Number Of Channelsupporting

confidence: 76%

Section: Introductionsupporting

confidence: 58%

In-Vitro Antibacterial Activity of Processed Moringa Oleifera Seed Extract: Kill-Time Study

Idris¹,

Muyibi²,

Jamal³

et al. 2013

TOPROCJ

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“…These compounds were stable under physiological conditions and were able to cleave supercoiled plasmid DNA in vitro [21]. The NO-iron complex DNIC-thiosulfate triggered apoptosis in Jurkat cells [22].…”

Section: Iron Compoundsmentioning

confidence: 99%

Non Platinum Metal Complexes as Anti‐cancer Drugs

Ott¹,

Gust

2007

Archiv der Pharmazie

544

403

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The development of metal complexes with platinum central atoms such as cisplatin or carboplatin had an enormous impact on current cancer chemotherapy. However, the spectrum of cancers that can be treated with platinum agents is narrow and treatment efficacy suffers from side effects and resistance phenomena. These unresolved problems in platinum-based anti-cancer therapy have stimulated increased research efforts in the search for novel non platinum-containing metal species as cytostatic agents. Preclinical and clinical investigations showed that the development of new metal agents with modes of action different from cisplatin is possible. Thus, complexes with iron, cobalt, or gold central atoms have shown promising results in preclinical studies and compounds with titanium, ruthenium, or gallium central atoms have already been evaluated in phase I and phase II trials. This review covers some relevant examples of preclinical and clinical research on novel non platinum metal complexes.

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“…DNICs induce apoptosis in Jurkat cells even when the anti-apoptotic molecule Bcl-2 is overexpressed (52). However, recent studies by Vanin and coworkers (53) demonstrated that DNICs (derived from GSH or cysteine) did not show any apoptotic activity in HeLa cells, in contrast to the pro-apoptotic effects of S-nitrosoglutathione (GSNO).…”

Section: Role Of Dnics In Cytotoxicitymentioning

confidence: 99%

Nitrogen Monoxide (NO) Storage and Transport by Dinitrosyl-Dithiol-Iron Complexes: Long-lived NO That Is Trafficked by Interacting Proteins

Rahmanto

Kalinowski

Lane

et al. 2012

Journal of Biological Chemistry

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Dinitrosyl-iron triggers apoptosis in Jurkat cells despite overexpression of Bcl-2

Cited by 69 publications

References 49 publications

In-Vitro Antibacterial Activity of Processed Moringa Oleifera Seed Extract: Kill-Time Study

In-Vitro Antibacterial Activity of Processed Moringa Oleifera Seed Extract: Kill-Time Study

Non Platinum Metal Complexes as Anti‐cancer Drugs

Nitrogen Monoxide (NO) Storage and Transport by Dinitrosyl-Dithiol-Iron Complexes: Long-lived NO That Is Trafficked by Interacting Proteins

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