Dinuclear iron, ruthenium and cobalt complexes containing 1,4-dimethyl-1,4,7-triazacyclononane ligands as well as carboxylato and oxo or hydroxo bridges
“…4 ) being in the range 2.802–2.861 Å [ [75] , [76] , [77] , [78] ]. In 2 , the Co1…Co2 distance is 3.577 Å lying within the range reported in the literature for dinuclear cobalt complexes bearing the structural motif II [ [71] , [72] , [73] , [74] ]. Fig.…”
Section: Resultssupporting
confidence: 82%
“…In type I, there are only two bridging carboxylato-O,O′ ligands showing a Co…Co distance in the range 3.917–4.030 Å [ 69 , 70 ]. The two carboxylato-O,O′ bridges may be also combined with one aqua bridge (type II) or two hydroxo bridges (type III) increasing the total number of bridges to three [ [71] , [72] , [73] , [74] ] and four [ 69 ], respectively. The Co…Co distance is in the range 3.358–3.574 Å in the structure of complexes showing bridging motif II [ [71] , [72] , [73] , [74] ], while for complexes of type III the Co…Co distance is shorter within the range 3.051–3.067 Å [ 69 ].…”
The interaction of cobalt chloride with the non-steroidal anti-inflammatory drug indomethacin (Hindo) led to the formation of the polymeric complex [Co(indo-O)
2
(H
2
O)
2
(μ-Cl)]
n
·n(MeOH·H
2
O) bearing one chlorido bridge between the cobalt atoms. The presence of the nitrogen-donor co-ligands 2,2′-bipyridine (bipy), 2,2′-bipyridylamine (bipyam), 1,10-phenanthroline (phen) or 1
H
-imidazole (Himi) resulted in the isolation of complexes [Co
2
(μ-indo-O,O′)
2
(indo-O)
2
(bipy)
2
(μ-H
2
O)]·3.3MeOH, [Co(indo-O,O′)
2
(bipyam)]·0.9MeOH·0.2H
2
O, [Co(indo-O,O′)
2
(phen)] (
4
) and [Co(indo-O)
2
(Himi)
2
] (
5
), respectively, where the indomethacin ligands were coordinated in diverse manners. The study of the affinity of the complexes for calf-thymus DNA revealed their intercalation between the DNA-bases. The binding of the complexes to albumins was also examined and the corresponding binding constants and binding subdomain were determined. The free radical scavenging activity of the compounds was evaluated towards 1,1-diphenyl-picrylhydrazyl and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid). Molecular modeling calculations may usually provide a molecular basis for the understanding of both the impairment of DNA by its binding with the studied complexes and the ability of these compounds to transportation through serum albumin proteins. This study can provide information for the elucidation of the mechanism of action of the compounds in a molecular level.
“…4 ) being in the range 2.802–2.861 Å [ [75] , [76] , [77] , [78] ]. In 2 , the Co1…Co2 distance is 3.577 Å lying within the range reported in the literature for dinuclear cobalt complexes bearing the structural motif II [ [71] , [72] , [73] , [74] ]. Fig.…”
Section: Resultssupporting
confidence: 82%
“…In type I, there are only two bridging carboxylato-O,O′ ligands showing a Co…Co distance in the range 3.917–4.030 Å [ 69 , 70 ]. The two carboxylato-O,O′ bridges may be also combined with one aqua bridge (type II) or two hydroxo bridges (type III) increasing the total number of bridges to three [ [71] , [72] , [73] , [74] ] and four [ 69 ], respectively. The Co…Co distance is in the range 3.358–3.574 Å in the structure of complexes showing bridging motif II [ [71] , [72] , [73] , [74] ], while for complexes of type III the Co…Co distance is shorter within the range 3.051–3.067 Å [ 69 ].…”
The interaction of cobalt chloride with the non-steroidal anti-inflammatory drug indomethacin (Hindo) led to the formation of the polymeric complex [Co(indo-O)
2
(H
2
O)
2
(μ-Cl)]
n
·n(MeOH·H
2
O) bearing one chlorido bridge between the cobalt atoms. The presence of the nitrogen-donor co-ligands 2,2′-bipyridine (bipy), 2,2′-bipyridylamine (bipyam), 1,10-phenanthroline (phen) or 1
H
-imidazole (Himi) resulted in the isolation of complexes [Co
2
(μ-indo-O,O′)
2
(indo-O)
2
(bipy)
2
(μ-H
2
O)]·3.3MeOH, [Co(indo-O,O′)
2
(bipyam)]·0.9MeOH·0.2H
2
O, [Co(indo-O,O′)
2
(phen)] (
4
) and [Co(indo-O)
2
(Himi)
2
] (
5
), respectively, where the indomethacin ligands were coordinated in diverse manners. The study of the affinity of the complexes for calf-thymus DNA revealed their intercalation between the DNA-bases. The binding of the complexes to albumins was also examined and the corresponding binding constants and binding subdomain were determined. The free radical scavenging activity of the compounds was evaluated towards 1,1-diphenyl-picrylhydrazyl and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid). Molecular modeling calculations may usually provide a molecular basis for the understanding of both the impairment of DNA by its binding with the studied complexes and the ability of these compounds to transportation through serum albumin proteins. This study can provide information for the elucidation of the mechanism of action of the compounds in a molecular level.
“…The Ru–Ru distances of 3.396 and 3.409 Å, in 1 and 2 , respectively, however, match well with that of [Ru III 2 (μ-O)(μ-C 3 H 7 COO)(tpa) 2 ](PF 6 ) 3 (3.399 Å) . Bond parameters involving {Ru(acac) 2 } and {Ru–acetate–Ru} fragments are in general agreement with the reported analogous systems. , …”
supporting
confidence: 84%
“…Diruthenium complexes involving a μ-oxo and bis(μ-carboxylato) tribridging core, {Ru(μ-O)(μ-RCOO) 2 Ru} ( A ), had been explored extensively in combination with varying ancillary ligands as a model system for the iron- and manganese-derived metalloproteins, hemerythrin, and oxygen-evolving complex (OEC) in photosystem II, respectively . The primary thrust was to scrutinize structural aspects, electron-transfer processes, and their application potential in homogeneous catalysis . The corresponding doubly bridged diruthenium core {Ru(μ-O)(μ-RCOO)Ru} ( B ) is, however, rare.…”
An unprecedented diastereomeric pair
[meso, ΔΛ (1); rac, ΔΔ/ΛΛ (2)] involving a doubly
oxido–carboxylato-bridged mixed-valent RuIIIRuIV (d5d4, S = 1/2) state in [(acac)2RuIII(μ-O)(μ-CH3COO)RuIV(acac)2] (acac = acetylacetonate)
was structurally characterized. 1
n
and 2
n
(n = +, 0, −) display comparable spectroelectrochemical features
for the accessible redox states.
“…These complexes are known to provide new reactivity patterns, because the interactions between the metals in these complexes help in promoting reaction as they will have greater oxidizing power. Some of the macrocyclic complexes used in catalyzing chemical reactions are given in Refs 27–44,. and these have been used as catalysts in chemical reactions.…”
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