Dipeptidyl Peptidase IV: A Target for Improving Metabolic Syndrome Components in Obese Children and Adolescents

Alameey, Inas R. El; Ahmed, Hanaa H.; AbuShady, Mones M.

doi:10.13005/bpj/1799

Cited by 3 publications

(1 citation statement)

References 44 publications

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“…Thus, DPP-IV inhibitors can extend GLP-1 and GIP action, and also enhance blood glucose regulation, which is considered a novel treatment against T2D [ 58 ]. DPP-IV activity has been related to metabolic syndrome (MS) in obese children and adolescents by El-Alameey et al [ 60 ], where serum DPP-IV activity of obese patients with MS was significantly elevated in relation to obese patients without MS and control subjects. Trzaskalski et al [ 61 ] also attributed to DDP-IV an important role in metabolic disease.…”

Section: Resultsmentioning

confidence: 99%

Critical Review for the Production of Antidiabetic Peptides by a Bibliometric Approach

et al. 2022

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The current bibliometric review evaluated recent papers that researched dietary protein sources to generate antidiabetic bioactive peptides/hydrolysates for the management of diabetes. Scopus and PubMed databases were searched to extract bibliometric data and, after a systematic four-step process was performed to select the articles, 75 papers were included in this review. The countries of origin of the authors who published the most were China (67%); Ireland (59%); and Spain (37%). The journals that published most articles on the subject were Food Chemistry (n = 12); Food & Function (n = 8); and Food Research International (n = 6). The most used keywords were ‘bioactive peptides’ (occurrence 28) and ‘antidiabetic’ (occurrence 10). The most used enzymes were Alcalase® (17%), Trypsin (17%), Pepsin, and Flavourzyme® (15% each). It was found that different sources of protein have been used to generate dipeptidyl peptidase IV (DPP-IV), α-amylase, and α-glucosidase inhibitory peptides. In addition to antidiabetic properties, some articles (n = 30) carried out studies on multifunctional bioactive peptides, and the most cited were reported to have antioxidant and antihypertensive activities (n = 19 and 17, respectively). The present review intended to offer bibliometric data on the most recent research on the production of antidiabetic peptides from dietary proteins to those interested in their obtention to act as hypoglycemic functional ingredients. The studies available in this period, compiled, are not yet enough to point out the best strategies for the production of antidiabetic peptides from food proteins and a more systematic effort in this direction is necessary to allow a future scale-up for the production of these possible functional ingredients.

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Section: Resultsmentioning

confidence: 99%

Critical Review for the Production of Antidiabetic Peptides by a Bibliometric Approach

et al. 2022

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Adipokines in the Crosstalk between Adipose Tissues and Other Organs: Implications in Cardiometabolic Diseases

Hemat Jouy,

Mohan,

Scichilone

et al. 2024

Biomedicines

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Adipose tissue was previously regarded as a dormant organ for lipid storage until the identification of adiponectin and leptin in the early 1990s. This revelation unveiled the dynamic endocrine function of adipose tissue, which has expanded further. Adipose tissue has emerged in recent decades as a multifunctional organ that plays a significant role in energy metabolism and homeostasis. Currently, it is evident that adipose tissue primarily performs its function by secreting a diverse array of signaling molecules known as adipokines. Apart from their pivotal function in energy expenditure and metabolism regulation, these adipokines exert significant influence over a multitude of biological processes, including but not limited to inflammation, thermoregulation, immune response, vascular function, and insulin sensitivity. Adipokines are pivotal in regulating numerous biological processes within adipose tissue and facilitating communication between adipose tissue and various organs, including the brain, gut, pancreas, endothelial cells, liver, muscle, and more. Dysregulated adipokines have been implicated in several metabolic diseases, like obesity and diabetes, as well as cardiovascular diseases. In this article, we attempted to describe the significance of adipokines in developing metabolic and cardiovascular diseases and highlight their role in the crosstalk between adipose tissues and other tissues and organs.

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Assessment of retinol-binding protein-4, fibroblast growth factor-21, and dipeptidyl peptidase-4 in relation to obesity and insulin resistance of type 2 diabetes mellitus among Egyptian patients

Ghanem,

Bassyouni,

Omar

2021

Journal of the Arab Society for Medical Research

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Background/aim The relation between obesity, inflammation, and insulin resistance (IR) shows that adipose tissue plays a significant secretory role. Adipokines such as retinol-binding protein-4 (RBP-4), fibroblast growth factor-21 (FGF21), and dipeptidyl peptidase-4 (DPP4) exhibit pleiotropic biological activities and might be valuable biomarkers involved in the pathogenesis of type 2 diabetes mellitus (T2DM). The present study aims to assess serum levels of RBP-4, FGF21, and DPP4 and correlate their relation with obesity and IR in Egyptian patients with T2DM. Patients and methods This study included 130 patients with T2DM (70 obese and 60 nonobese) enrolled from the inpatient and outpatient clinics of the National Institute of Diabetes and Endocrinology (NIDE), Cairo, Egypt, in addition to 70 age-matched and sex-matched healthy individuals (35 obese and 35 nonobese). Serum level assessments of RBP-4, FGF21, and DPP4 were carried out on all participants using Enzyme Linked Immuno-Sorbent Assay technique. Results Serum levels of RBP-4, FGF21, and DPP4 showed statistically significant differences in all studied groups (P<0.01). RBP-4, FGF21, and DPP4 were all correlated positively with BMI, fasting insulin, and HOMA-IR. RPB-4 was negatively correlated with high-density lipoprotein-cholesterol. Both RBP-4 and FGF21 were significantly associated with IR (odds ratio=1.264; P<0.001, and odds ratio=1.059; P<0.01, respectively), whereas receiver operating characteristic curves analysis revealed that serum levels of RBP-4 were most significant [area under curve (AUC)=0.826, P=<0.001], followed by FGF21 (AUC=0.774, P<0.001) and finally DPP4 (AUC=0.677, P<0.001). Conclusions Obesity and IR were found to be significantly associated with RBP-4, FGF21, and DPP4. They were higher in all obese groups, with the diabetic obese group having the highest concentrations. Of the three adipokines studied, RBP-4 has the strongest link. This finding will bolster the adipose-derived factors use as biomarkers and targets for treating and managing obesity and T2DM.

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Dipeptidyl Peptidase IV: A Target for Improving Metabolic Syndrome Components in Obese Children and Adolescents

Cited by 3 publications

References 44 publications

Critical Review for the Production of Antidiabetic Peptides by a Bibliometric Approach

Critical Review for the Production of Antidiabetic Peptides by a Bibliometric Approach

Adipokines in the Crosstalk between Adipose Tissues and Other Organs: Implications in Cardiometabolic Diseases

Assessment of retinol-binding protein-4, fibroblast growth factor-21, and dipeptidyl peptidase-4 in relation to obesity and insulin resistance of type 2 diabetes mellitus among Egyptian patients

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