Diphenyl diselenide exerts antidepressant-like and anxiolytic-like effects in mice: Involvement of l-arginine-nitric oxide-soluble guanylate cyclase pathway in its antidepressant-like action

Antinociceptive and anti-hyperalgesic effects of bis(4-methylbenzoyl) diselenide in mice: Evidence for the mechanism of action

“…In the last two decades, the interest in organoselenium biochemistry and pharmacology has increased due to a variety of compounds that show biological activity (May, 1999;Nogueira et al, 2004, Nogueira & Rocha, 2011. In fact, its compounds show antioxidant (Gerzson et al, 2012;Luchese et al, 2009;Nogueira et al, 2004;Prigol et al, 2009), neuroprotective (Porciúncula et al, 2003), antidepressant-like (Gerzson et al, 2012;Oliveira et al, 2012;Savegnago et al, 2008), antihypertensive, anticancer, antiviral, immunosuppressive, and antimicrobial properties (May, 1999;Nogueira et al, 2004;Schewe, 1995). Recently, our group of research showed hepatoprotective effect of bis(4-methylbenzoyl) diselenide (BMD), an disubstituted diaryl diselenide, against carbon tetrachloride (CCl 4 )-induced oxidative damage in mice possibly by modulating the antioxidant status (Filho et al, 2013).…”

Effects of diphenyl diselenide on depressive-like behavior in ovariectomized mice submitted to subchronic stress: involvement of the serotonergic system

“…Based upon this point of view, diphenyl diselenide (PhSe) 2 , an organoselenium compound, has been reported as a potential pharmacological agent (Nogueira et al 2004;Nogueira and Rocha 2010) with antidepressantlike properties (Ghisleni et al 2008;Savegnago et al 2007Savegnago et al , 2008.…”

Antioxidant effect of functionalized alkyl-organotellurides: a studyin vitro

“…The resulting mixture was stirred for 1 h at room temperature then quenched with water and diluted with hexane/ethyl acetate (5 mL, 1:1). The organic and aqueous phases were separated and the organic phase was washed with NH 4 Cl solution (3 × 15 mL) and brine (3 × 15 mL) and then dried with MgSO 4 . The solution was filtered and the solvent was evaporated.…”

“…sol., 2 × 20 mL), water (2 × 20 mL), and brine (20 mL). The organic phases were combined, dried with MgSO 4 , and filtered and the solvents were removed under reduced pressure. The residue was purified by silica gel column chromatography, eluting with a mixture of hexane/ …”

“…Evidence has been provided that organochalcogenides, such as organoselenium and organotellurium compounds, are promising pharmacological agents [1][2][3][4] . Organotellurium compounds have been synthesized since 1840 5 , and it is known that these compounds are much more effective bioactive agents than their corresponding selenium and sulfur analogs, with evident chemoprotective, antioxidative, and cytotoxic properties 3,6 , making these compounds extremely attractive in medical therapies.…”