Diphenylarsinic acid induced activation of MAP kinases, transcription factors, and oxidative stress-responsive factors and hypersecretion of cytokines in cultured normal human cerebellar astrocytes

Sasaki, Shoto; Negishi, Takayuki; Tsuzuki, Takamasa; Yukawa, Kazunori

doi:10.1016/j.neuro.2021.12.002

Cited by 7 publications

(2 citation statements)

References 38 publications

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“…However, DPAA and related substances have been found to contaminate fish, shellfish, and soil [8][9][10][11][12][13][14]. The clinical findings in DPAA poisoning patients [15] and animal studies [93][94][95] are consistent with the brain being the target organ. Toxicological information on DPAA suggests that it may be the most dangerous of the arsenic compounds.…”

Section: Diphenylchloroarsine (Da) and Diphenylcyanoarsine (Dc)mentioning

confidence: 93%

“…Before this incident, there was no toxicological data on DPAA. DPAA can pass through the BBB in trace amounts and target the cerebellum, causing disruption of the glutamatergic system [93,94]. A summary document published by the Japanese Ministry of the Environment [95] revealed that DPAA is mainly absorbed in the gastrointestinal tract, while a mere amount is absorbed through the skin.…”

Section: Diphenylchloroarsine (Da) and Diphenylcyanoarsine (Dc)mentioning

confidence: 99%

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Arsenic Exposure and Health Effects: Differences by Chemical Structure, Chemical Form and Arsenic Methylation Capacity

Yamauchi¹,

Yoshida²,

Takata³

2023

Arsenic in the Environment - Sources, Impacts and Remedies

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Large-scale chronic arsenic poisoning in several areas worldwide has not been eradicated. Adverse health effects of inorganic arsenic (iAs) exposure are associated with decreased arsenic methylation capacity (AMC). The AMC results from 21 children and 39 adults with acute arsenic poisoning support and effectively guide the analysis and evaluation of AMC in chronic arsenic poisoning. Results of the 65th-year follow-up for 6,223 cases of infants, who survived subacute arsenic poisoning, contribut to future projections against health effects (cancer and cognitive dysfunction). Currently, arsenolipids from fish and shellfish are attracting attention because of their direct association with brain dysfunction. Accordingly, the European Food Safety Authority is considering legal restrictions on their dietary intake. Modern society overlooks the environmental contamination and health hazards caused by arsenic chemical weapons mainly produced during World War II. This review aims to evaluation the various health effects of AMC reduction in acute, subacute, and chronic arsenic poisoning, in addition to the methylarsenic compounds such as arsenolipids, arsenosugars, and arsenobetaine, as well as arsenic chemical weapons like lewisite, diphenylchloroarsin, and diphenylcyanoarsine.

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