Diplopia – An Unusual Primary Manifestation of Metastatic Renal Cell Carcinoma

Khaitan, A.

doi:10.1159/000080845

Cited by 6 publications

(2 citation statements)

References 8 publications

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“…The nuclear/cytoplasmic ratio remains low; necrosis and mitotic activity are not seen metastatic RCC needs to be ruled out. Metastatic RCC has a predilection for the sinonasal tract [3][4][5] and sinonasal metastatic disease may be the initial presentation [6][7][8]. RCC is the most common carcinoma to metastasize to the sinonasal tract [9].…”

Section: Discussionmentioning

confidence: 99%

Sinonasal Renal Cell-like Adenocarcinoma: A Report on Four Patients

Storck

Hadi

Simpson

et al. 2008

Head and Neck Pathol

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Section: Discussionmentioning

confidence: 99%

Sinonasal Renal Cell-like Adenocarcinoma: A Report on Four Patients

Storck

Hadi

Simpson

et al. 2008

Head and Neck Pathol

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“…5 This has been a presenting symptom in previously described metastatic sphenoid lesions. 7 A cavernous sinus lesion may progress to complete ophthalmoplegia that is usually painful and is commonly associated with deficits in the first or second division of the trigeminal nerve. Although the incidence of sphenoid sinus malignancies is low, the sphenoid is the most commonly involved sinus when cranial neuropathy is present.…”

Section: Discussionmentioning

confidence: 99%

Hepatocellular Carcinoma Presenting as An Isolated Sphenoid Sinus Lesion: A Case Report

Tandon¹,

Nair²,

Balasubramanya

et al. 2012

Ear Nose Throat J

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We report a rare case of a metastatic sphenoid sinus lesion originating from an undiagnosed hepatocellular carcinoma (HCC) in a 53-year-old man who presented with gradually progressive external ophthalmoplegia. Imaging showed a right sphenoid sinus lesion infiltrating the parasellar region. Although a primary sphenoid biopsy was inconclusive, positive hepatitis B surface antigen and CT-guided fine-needle aspiration cytology suggested an HCC. A repeat endoscopic biopsy from the sphenoid with immunohistochemistry confirmed the lesion to be metastatic HCC. Metastasis to the paranasal sinuses is extremely rare, and metastasis from a liver primary even more rare. Because of clinical and radiologic similarity between the primary and metastatic lesions, metastasis to the sphenoid sinus is often undiagnosed. Patients with features suggestive of sphenoid sinus malignancy should also be evaluated for the possibility of a metastatic tumor. In this article, we emphasize the rarity of the tumor, the unusual presenting symptoms, and problems with early diagnosis.

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Metastasis of Occult Prostatic Carcinoma to the Sphenoid Sinus: Report of a Rare Case and a Review of the Literature

Petersson

Hui

Loke

et al. 2011

Head and Neck Pathol

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We present a case (55-year-old) with a metastasis to the sphenoid sinus from an occult prostatic adenocarcinoma as the first evidence of disease. The patient's symptoms were progressive left-sided headache of a few months duration and a 2-week history of blurred vision with diplopia. Clinical examination revealed a left cranial nerve III palsy and ptosis. A computed tomography scan showed a 2 cm large, well delineated soft tissue lesion involving the left sphenoid sinus and extending to the left cavernous sinus with sclerosis of the adjacent sphenoid bone. Histological and immunohistochemical examinations revealed a poorly differentiated adenocarcinoma that was positive for prostate specific antigen (PSA) and broad-spectrum cytokeratins (Cam 5.2). Subsequent urological examination confirmed a locally advanced prostatic carcinoma with significantly increased serum-PSA (4,561 μg/l) and bone scintigraphy showed widespread metastasis.

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Diplopia – An Unusual Primary Manifestation of Metastatic Renal Cell Carcinoma

Cited by 6 publications

References 8 publications

Sinonasal Renal Cell-like Adenocarcinoma: A Report on Four Patients

Sinonasal Renal Cell-like Adenocarcinoma: A Report on Four Patients

Hepatocellular Carcinoma Presenting as An Isolated Sphenoid Sinus Lesion: A Case Report

Metastasis of Occult Prostatic Carcinoma to the Sphenoid Sinus: Report of a Rare Case and a Review of the Literature

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