Direct action of capsaicin in brown adipogenesis and activation of brown adipocytes

Kida, Ryosuke; Yoshida, Hiroo; Murakami, Masaru; Shirai, Mitsuyuki; Hashimoto, Osamu; Kawada, Teruo; Matsui, Tohru; Funaba, Masayuki

doi:10.1002/cbf.3162

Cited by 50 publications

(54 citation statements)

References 51 publications

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Section: Role Of Thermo-sensitive Trp Channels In Adipose Tissuementioning

confidence: 99%

“…13) TRPV1 is expressed in brown adipocytes, [55][56][57] and adipocyte cell lines such as the HB2 brown adipocyte cell line and the 3T3-L1 adipocyte cell line. 55) In 3T3-L1 cells, activation of TRPV1 by capsaicin induces calcium influx and prevents adipogenesis. 58) Opposite results were also reported and showed that treatment with capsaicin in the late stage slightly increased expression levels of fatty acid-binding protein 4 (Fabp4), Pparγ2, and peroxisome proliferator-activated receptor γ coactivator-1α (Pgc-1α) in the HB2 brown adipocyte cell line.…”

Section: Role Of Thermo-sensitive Trp Channels In Adipose Tissuementioning

confidence: 99%

“…58) Opposite results were also reported and showed that treatment with capsaicin in the late stage slightly increased expression levels of fatty acid-binding protein 4 (Fabp4), Pparγ2, and peroxisome proliferator-activated receptor γ coactivator-1α (Pgc-1α) in the HB2 brown adipocyte cell line. 55,59) Pharmacological inhibition of TRPV1 activity also enhanced expression levels of Pgc-1α mRNA, which is a key transcriptional coregulator of oxidative metabolism and thermogenesis. 60) In addition, activation of TRPV1 by capsaicin up-regulates expression of thermogenic genes and induces the "browning" phenotype in differentiating 3T3-L1 pre-adipocytes ( Fig.…”

Section: Role Of Thermo-sensitive Trp Channels In Adipose Tissuementioning

confidence: 99%

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Role of Thermo-Sensitive Transient Receptor Potential Channels in Brown Adipose Tissue

Uchida

Sun

Yamazaki

et al. 2018

Biological & Pharmaceutical Bulletin

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Brown and beige adipocytes are a major site of mammalian non-shivering thermogenesis and energy dissipation. Obesity is caused by an imbalance between energy intake and expenditure and has become a worldwide health problem. Therefore modulation of thermogenesis in brown and beige adipocytes could be an important application for body weight control and obesity prevention. Over the last few decades, the involvement of thermo-sensitive transient receptor potential (TRP) channels (including TRPV1, TRPV2, TRPV3, TRPV4, TRPM4, TRPM8, TRPC5, and TRPA1) in energy metabolism and adipogenesis in adipocytes has been extensively explored. In this review, we summarize the expression, function, and pathological/ physiological contributions of these TRP channels and discuss their potential as future therapeutic targets for preventing and combating human obesity and obesity-related metabolic disorders.

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Section: Role Of Thermo-sensitive Trp Channels In Adipose Tissuementioning

confidence: 99%

Section: Role Of Thermo-sensitive Trp Channels In Adipose Tissuementioning

confidence: 99%

Section: Role Of Thermo-sensitive Trp Channels In Adipose Tissuementioning

confidence: 99%

See 1 more Smart Citation

Role of Thermo-Sensitive Transient Receptor Potential Channels in Brown Adipose Tissue

Uchida

Sun

Yamazaki

et al. 2018

Biological & Pharmaceutical Bulletin

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“…Administration of capsaicin in mice has shown to induce thermogenesis via the activation of BAT [88]. This is evidenced by the increase in markers related to mitochondrial biogenesis such as PPARγ, PGC-1α and UCP1 [88].…”

Section: Phytochemicals In Obesitymentioning

confidence: 99%

“…This is evidenced by the increase in markers related to mitochondrial biogenesis such as PPARγ, PGC-1α and UCP1 [88]. Capsaicin also induces the development of beige adipocytes at an early stage of adipogenesis [88].…”

Section: Phytochemicals In Obesitymentioning

confidence: 99%

Phytochemicals as novel agents for the induction of browning in white adipose tissue

et al. 2016

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Obesity and its associated metabolic syndrome continue to be a health epidemic in westernized societies and is catching up in the developing world. Despite such increases, little headway has been made to reverse adverse weight gain in the global population. Few medical options exist for the treatment of obesity which points to the necessity for exploration of anti-obesity therapies including pharmaceutical and nutraceutical compounds. Defects in brown adipose tissue, a major energy dissipating organ, has been identified in the obese and is hypothesized to contribute to the overall metabolic deficit observed in obesity. Not surprisingly, considerable attention has been placed on the discovery of methods to activate brown adipose tissue. A variety of plant-derived, natural compounds have shown promise to regulate brown adipose tissue activity and enhance the lipolytic and catabolic potential of white adipose tissue. Through activation of the sympathetic nervous system, thyroid hormone signaling, and transcriptional regulation of metabolism, natural compounds such as capsaicin and resveratrol may provide a relatively safe and effective option to upregulate energy expenditure. Through utilizing the energy dissipating potential of such nutraceutical compounds, the possibility exists to provide a therapeutic solution to correct the energy imbalance that underlines obesity.

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Role of estradiol and testosterone in Ucp1 expression in brown/beige adipocytes

Suzuki

Murakami

Shirai

et al. 2018

Cell Biochemistry & Function

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Activity of brown/beige adipocytes is higher in women than in men. The expression level of uncoupling protein 1 (UCP1) is largely consistent with the thermogenic activity in brown/beige adipocytes. The present study examined the direct effects of sex hormones on Ucp1 expression in brown adipocytes and beige adipocytes, which were differentiated from HB2 brown preadipocytes and 3T3‐L1 white preadipocytes, respectively; treatment with estradiol or testosterone was used during the early (days 0‐8) or late stage (days 8‐12) of brown adipogenesis and beige adipogenesis. On day 8 or day 12, cells were treated with or without isoproterenol (Iso), an agonist for the β‐adrenergic receptor, for 4 hours. Furthermore, the sex of cells was examined; the sex‐determining region y gene, which is located on the y chromosome, was present in HB2 cells, but not in 3T3‐L1 cells, suggesting that HB2 cells and 3T3‐L1 cells are male and female cells, respectively. Treatment with 17β‐estradiol during the early stage of brown adipogenesis enhanced the responsiveness to Iso on Ucp1 induction, whereas treatment during the late stage of brown adipogenesis decreased Ucp1 expression in unstimulated brown adipocytes. Estradiol decreased Iso‐induced Ucp1 expression during the early stage of beige adipogenesis. Treatment with testosterone during the early stage of brown adipogenesis did not affect Ucp1 expression but increased the responsiveness to Iso on Ucp1 induction by the treatment during the late stage of brown adipogenesis. The present results suggest that sex hormones modulate the expression level of Ucp1 in brown/beige adipocytes in a stage‐dependent manner. Direct effects of sex hormones in brown/beige adipogenesis were evaluated. Treatment with 17β‐estradiol during the early stage of brown adipogenesis enhanced the responsiveness to isoproterenol (Iso), an agonist for the β‐adrenergic receptor, on Ucp1 induction, whereas treatment during the late stage of brown adipogenesis decreased Ucp1 expression in unstimulated brown adipocytes. Estradiol decreased Iso‐induced Ucp1 expression during the early stage of beige adipogenesis. Testosterone during the late stage of brown adipogenesis increased the responsiveness to Iso on Ucp1 induction. Sex hormones modulate the expression level of Ucp1 in brown/beige adipocytes in a stage‐dependent manner.

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Direct action of capsaicin in brown adipogenesis and activation of brown adipocytes

Cited by 50 publications

References 51 publications

Role of Thermo-Sensitive Transient Receptor Potential Channels in Brown Adipose Tissue

Role of Thermo-Sensitive Transient Receptor Potential Channels in Brown Adipose Tissue

Phytochemicals as novel agents for the induction of browning in white adipose tissue

Role of estradiol and testosterone in Ucp1 expression in brown/beige adipocytes

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