Direct and facile synthesis of 9-aminoacridine and acridin-9-yl-ureas

Боровлев, И. В.; Демидов, О. П.; Amangasieva, Gulminat A.; Avakyan, Elena K.

doi:10.1016/j.tetlet.2016.06.103

Cited by 11 publications

(3 citation statements)

References 18 publications

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“…The synthesized compound 3 showed complex NMR spectra (see ESI, Supporting information, Figure S1) which is typical for the 9‐amido acridine derivatives due to their existence in tautomeric equilibrium 41 (Scheme 2).…”

Section: Experimental Section/methodsmentioning

confidence: 99%

Photoactive mussels inspired polymer coatings: Preparation and antibacterial activity

Bryaskova

Philipova

Georgiev

et al. 2021

J of Applied Polymer Sci

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In this article we report on the facile preparation of photoactive antibacterial mussel inspired polymer coatings deposited on a stainless steel (SS) substrate from water based precursors. The coating is prepared by the sequential deposition of aqueous based solutions of an anchoring layer based on bio‐inspired glue, a cationic polymer bearing pendent catechols, a nanogel decorated by ortho‐quinones and a photosensitizer of the aminoacridine type. This latter is grafted to the coating by reaction of its amino group with the o‐quinone of the deposited nanogel. The deposition of all layers is followed in‐line by Quartz crystal microbalance coupled with dissipation (QCM‐D) and AFM shows that the thin polymer film repeated the roughness of the SS substrate. The prepared coatings show good mechanical properties applying nanoindentation techniques. The established antibacterial activity of the prepared photoactive polymer coatings on SS against Gram‐negative E. coli strain demonstrate their potential as a power tool for medical applications.

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Section: Experimental Section/methodsmentioning

confidence: 99%

Photoactive mussels inspired polymer coatings: Preparation and antibacterial activity

Bryaskova

Philipova

Georgiev

et al. 2021

J of Applied Polymer Sci

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“…Various attempts to functionalize compound 2 at its 16-position proved unsuccessful. For example, our efforts to introduce an amino group, as reported for the conversion of acridine into its 9-amino derivative (urea and sodium hydride in dimethylsulfoxide), 32 only led to the recovery of the starting material. Similarly, our attempt to oxidize 2 into the corresponding acridone, as reported in the case of acridines (sodium hydride in dimethylsulfoxide), 33 failed (starting material recovered, even after heating at 80 °C overnight).…”

Section: Articlementioning

confidence: 99%

Aza-aromatic polycycles based on triphenylene and acridine or acridone: synthesis and properties

et al. 2021

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“…Compound 6 was synthesized according to the published literature [11] and the characterization data was consistent with the literature.…”

Section: Synthesis Of 2-mercapto-4-hydroxyquinazoline (6)mentioning

confidence: 99%

Design, Synthesis and Antitumor Activity Evaluation of 4-Aminoquinazoline Derivatives Containing Urea Moiety

李二冬¹,

孟娅琪²,

张路野³

et al. 2019

Chinese Journal of Organic Chemistry

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a 郑州大学药学院郑州 450001) (b 新药创制与药物安全性评价河南省协同创新中心郑州 450001) (c 河南省药物质量评价重点实验室郑州 450001) (d 教育部药物制备关键技术重点实验室郑州 450001) 摘要为了寻找新的具有靶向治疗作用的抗肿瘤药物, 设计并合成了一系列新型的含脲砌块的 4-氨基喹唑啉类衍生物, 并采用噻唑蓝(MTT)法测定目标化合物对 MCF-7(人乳腺癌细胞)、MGC-803(人胃癌细胞)、SW620(人结肠癌细胞)、 A549(人肺癌细胞)四种肿瘤细胞的抗肿瘤活性. 结果显示大部分化合物具有较好的抗肿瘤活性, 其中 2-((4-((3,4,5-三甲氧基苯基)-氨基)喹唑啉-2-基)-硫代)-N-((3,4,5-三甲氧基苯基)氨基甲酰基)乙酰胺(10p)对 MGC-803、SW620 和 A549 三种细胞显示出最好的抗肿瘤活性, IC 50 值分别为(7.02±0.46)、(6.00±0.78)和(7.04±1.11) µmol•L-1 , 其抗肿瘤活性和阳性对照品吉非替尼相当. 分子对接结果显示, 化合物 10p 能与 EGFR 很好地结合, 有可能成为潜在的抗肿瘤药物.

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Direct and facile synthesis of 9-aminoacridine and acridin-9-yl-ureas

Cited by 11 publications

References 18 publications

Photoactive mussels inspired polymer coatings: Preparation and antibacterial activity

Photoactive mussels inspired polymer coatings: Preparation and antibacterial activity

Aza-aromatic polycycles based on triphenylene and acridine or acridone: synthesis and properties

Design, Synthesis and Antitumor Activity Evaluation of 4-Aminoquinazoline Derivatives Containing Urea Moiety

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