2015
DOI: 10.1016/j.carres.2015.06.003
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Direct aqueous synthesis of non-protected glycosyl sulfoxides; weak inhibitory activity against glycosidases

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Cited by 3 publications
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“…5 Recently, endocyclic sulfur or selenium containing carbohydrate mimetics with the positively charged heteroatom have been reported to act as potent glycosidase inhibitors, 6 while glycosyl sulfoxides displayed only weak activity towards glycosidases. 7 Various fuco-configured pyrrolidotriazoles have been found to exhibit enhanced inhibition of α-fucosidase and their impact on several α-glucosidases was aglycone dependent. 8 Modulation of affinity and selectivity towards various glycosidases by ligand multivalency has been demonstrated for mono-, diand tri-valent iminosugars 9 (Fig.…”
Section: Introductionmentioning
confidence: 99%
“…5 Recently, endocyclic sulfur or selenium containing carbohydrate mimetics with the positively charged heteroatom have been reported to act as potent glycosidase inhibitors, 6 while glycosyl sulfoxides displayed only weak activity towards glycosidases. 7 Various fuco-configured pyrrolidotriazoles have been found to exhibit enhanced inhibition of α-fucosidase and their impact on several α-glucosidases was aglycone dependent. 8 Modulation of affinity and selectivity towards various glycosidases by ligand multivalency has been demonstrated for mono-, diand tri-valent iminosugars 9 (Fig.…”
Section: Introductionmentioning
confidence: 99%