Direct auditory cortical input to the lateral periaqueductal gray controls sound-driven defensive behavior

Wang, Haitao; Chen, Jiahui; Xu, Xin; Sun, Wenli; Chen, Xi; Zhao, Fei; Luo, Min‐Hua; Liu, Chunhua; Guo, Yiping; Xie, Wen; Zhong, Hui; Bai, Tongjian; Tian, Yanghua; Mao, Yu; Ye, Chonghuan; Tao, Wenjuan; Li, Jie; Farzinpour, Zahra; Li, Juan; Zhou, Jiang‐Ning; Wang, Kai; He, Jufang; Chen, Lin; Zhang, Zhi

doi:10.1371/journal.pbio.3000417

Cited by 30 publications

(30 citation statements)

References 51 publications

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“…Beyond behavioral selection, cortical circuits are also well positioned to transmit to the dPAG sensory information important for escape behavior. The auditory cortex in particular has recently been shown to form a monosynaptic pathway with excitatory dPAG neurons, and modulating its activity has the ability to enhance and decrease sound-evoked escape behavior [41]. This pathway might be useful for complex or ambiguous sounds that may require cortical processing to establish stimulus identity, such as vocalizations, and future studies could test this hypothesis directly.…”

Section: Integrating Brain-wide Information To Modulate Escapementioning

confidence: 99%

The role of the periaqueductal gray in escape behavior

Lefler¹,

Campagner

Branco³

2020

Current Opinion in Neurobiology

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Escape behavior is a defensive action deployed by animals in response to imminent threats. In mammalian species, a variety of different brain circuits are known to participate in this critical survival behavior. One of these circuits is the periaqueductal gray, a midbrain structure that can command a variety of instinctive behaviors. Recent experiments using modern systems neuroscience techniques have begun to elucidate the specific role of the periaqueductal gray in controlling escape. These have shown that periaqueductal gray neurons are critical units for gating and commanding the initiation of escape, specifically activated in situations of imminent, escapable threat. In addition, it is becoming clear that the periaqueductal gray integrates brainwide information that can modulate escape initiation to generate flexible defensive behaviors.

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Section: Integrating Brain-wide Information To Modulate Escapementioning

confidence: 99%

The role of the periaqueductal gray in escape behavior

Lefler¹,

Campagner

Branco³

2020

Current Opinion in Neurobiology

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“…3 A , B ). The AS experiment was conducted with the same structure as the VR experiment and using auditory stimulus previously used to induce a defensive behavior detectable as a pupillary and behavioral response ( Xiong et al, 2015 ; Wang et al, 2019 ; Hersman et al, 2020 ; Li et al, 2021 ). An initial period of habituation was followed by auditory stimulation using two tones (tone 1, 3 kHz; tone 2, 4 kHz; duration, 20 s; interstimulus interval, 120 s; Fig.…”

Section: Resultsmentioning

confidence: 99%

MEYE: Web App for Translational and Real-Time Pupillometry

Mazziotti

Carrara

Viglione

et al. 2021

eNeuro

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Pupil dynamics alterations have been found in patients affected by a variety of neuropsychiatric conditions, including autism. Studies in mouse models have used pupillometry for phenotypic assessment and as a proxy for arousal. Both in mice and humans, pupillometry is noninvasive and allows for longitudinal experiments supporting temporal specificity; however, its measure requires dedicated setups. Here, we introduce a convolutional neural network that performs online pupillometry in both mice and humans in a web app format. This solution dramatically simplifies the usage of the tool for the nonspecialist and nontechnical operators. Because a modern web browser is the only software requirement, this choice is of great interest given its easy deployment and setup time reduction. The tested model performances indicate that the tool is sensitive enough to detect both locomotor-induced and stimulus-evoked pupillary changes, and its output is comparable to state-of-the-art commercial devices.

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“…However, pathways from the auditory system to the PAG target its dorsolateral and lateral sectors and are associated with sound driven flight behaviour (e.g. Wang et al, 2019), so presumably some other pathway is responsible. For example, the medial prefrontal cortex and the bed nucleus of stria terminalis have extensive projections to the PAG (Holstege et al, 1985;An et al, 1998), and after fear conditioning both show sustained changes in activity during presentation of the CS+ (Haufler et al, 2013;Gilmartin et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Cerebellar modulation of fear behaviour and memory encoding in the PAG

Lawrenson¹,

Paci²,

Drake³

et al. 2021

Preprint

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The pivotal role of the periaqueductal grey (PAG) in fear learning is reinforced by the identification of neurons in rat ventral (vPAG) that encode fear memory through signalling the onset and offset of an auditory conditioned stimulus during retrieval. Within this framework, understanding of cerebellar contributions to survival circuits is advanced by the discovery that: (i) reversible inactivation of the medial cerebellar nucleus (MCN) during fear consolidation (a) reduces the temporal precision of vPAG offset, but not onset responses and (b) increases rearing behaviour during retrieval, and (ii) chemogenetic inhibition of the MCN-vPAG projection during fear acquisition (a) reduces the emission of fear-related ultrasonic vocalisations and (b) slows the extinction rate of fear-related freezing. These findings show that the cerebellum regulates fear memory processes at multiple timescales and in multiple ways. The current findings indicate that dysfunctional interactions in the cerebellar-survival network may underlie fear-related disorders and comorbidities.

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Direct auditory cortical input to the lateral periaqueductal gray controls sound-driven defensive behavior

Cited by 30 publications

References 51 publications

The role of the periaqueductal gray in escape behavior

The role of the periaqueductal gray in escape behavior

MEYE: Web App for Translational and Real-Time Pupillometry

Cerebellar modulation of fear behaviour and memory encoding in the PAG

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