Direct brain recordings reveal occipital cortex involvement in memory development

Yin, Qin; Johnson, Elizabeth L.; Tang, Lingfei; Auguste, Kurtis I.; Knight, Robert T.; Asano, Eishi; Ofen, Noa

doi:10.1016/j.neuropsychologia.2020.107625

Cited by 23 publications

(33 citation statements)

References 62 publications

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“…Building on this foundational literature, we previously showed that attention-related alpha oscillations in primary visual cortex speed up with age during performance of the same task. 43 Here, we reveal that development is not only associated with the speeding of oscillations but also differentiation of the memory-relevant theta band to adult levels. Whereas faster oscillations reflect faster fluctuations between neuronal excitation and inhibition, 37 potentially subserving increased information processing during visual attention, 43 slower oscillations reflect more prolonged periods of excitation, potentially subserving increased information integration.…”

Section: Discussionmentioning

confidence: 72%

“…Previous research in large non-clinical samples has consistently demonstrated modest positive relationships between performance and age in children and adolescents, with marked variability among adolescents. 6,14,18,[44][45][46] More robust relationships have been reported in investigations that subdivided individual data based on stimulus and response criteria (e.g., scene complexity, recognition confidence) with consistent outcomes in ECoG 43 and non-clinical samples. 45 Thus, we show that these data reflect typical memory development and, in the second study aim, identify ECoG signatures of memory formation that differentiate top performing adolescents from both lower performing adolescents and children.…”

Section: Typical Trajectory Of Memory Developmentmentioning

confidence: 96%

“…To control for attention at study, trials with incorrect indoor/outdoor responses were excluded from all further analysis. 42,43 Of studied scenes with correct indoor/outdoor responses, a mean of 0.67 were correctly identified as old (i.e., hit), and the remaining 0.33 were incorrectly identified as new (miss; SD, 0.17). Of scenes used as foils at recognition, a mean of 0.69 were correctly identified as new, and the remaining 0.31 were incorrectly identified as old (false alarm; SD, 0.18).…”

Section: Typical Trajectory Of Memory Developmentmentioning

confidence: 99%

“…A time-frequency representation of power for each study trial was computed from 1.5 to 250 Hz, and event-related activity was quantified using statistical bootstrapping. 42,43 To identify signatures of memory formation, individual subsequent hit-and miss-trial outputs were averaged across electrodes within a region and submitted to permutation testing with cluster-based correction for multiple comparisons. 48 We first determined spectral signatures of memory formation in MTL by comparing activity during the encoding of subsequently recognized relative to forgotten scenes (i.e., subsequent memory analysis 1,6 ).…”

Section: Medial Temporal Spectral Signatures Of Memory Formationmentioning

confidence: 99%

“…To test these predictions, we analyzed electrocorticography (ECoG) data recorded during the performance of an established task of recognition memory for visual scenes. 6,14,18,[42][43][44][45][46][47] ECoG affords multiple advantages over noninvasive measures, including millisecond temporal and millimeter spatial resolution and high signal-to-noise ratio enabling single-trial precision, and thus provides a powerful tool in the study of human memory. 6,22,27 The aims were 3-fold.…”

Section: Introductionmentioning

confidence: 99%

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Dissociable oscillatory theta signatures of memory formation in the developing brain

Johnson¹,

Yin²,

O'Hara³

et al. 2022

Current Biology

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Section: Discussionmentioning

confidence: 72%

Section: Typical Trajectory Of Memory Developmentmentioning

confidence: 96%

Section: Typical Trajectory Of Memory Developmentmentioning

confidence: 99%

Section: Medial Temporal Spectral Signatures Of Memory Formationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Dissociable oscillatory theta signatures of memory formation in the developing brain

Johnson¹,

Yin²,

O'Hara³

et al. 2022

Current Biology

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Lower‐resolution retrieval of scenes in older adults with subjective cognitive decline

Ruiz‐Rizzo

Pruitt

Finke

et al. 2020

Alzheimer's & Dementia

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Background Subjective cognitive decline (SCD) can predict the progression to mild cognitive impairment. Visual memory deficits in mildly impaired patients relate to decreased activity in brain regions beyond the medial temporal lobe, such as the parahippocampal place area (PPA). PPA's response to visual scenes is weaker in healthy older than younger adults but equally associated with memory recognition. PPA's response to scenes' perceptual details during encoding might support that association. Whether perceptual detail processing is reduced in SCD can help elucidate the disparity between perceived decline and normal performance. Here we test whether older adults with SCD ('SCD') use perceptual details to a lesser extent than older adults without SCD ('CON') and whether this is observed during the encoding or retrieval of a scene memory task. Methods We measured BOLD‐fMRI activity in 37 healthy older adults (SCD: 16) during encoding, and calculated hit rate, false alarm rate, and total recognition accuracy during retrieval. We analyzed BOLD‐fMRI activity during scene encoding in PPA. PPA was defined based on a functional Neurosynth meta‐analysis of studies including the term "place" and further constrained to the lingual and posterior parahippocampal gyri, and posterior‐temporal and temporal‐occipital fusiform cortices. Scenes' perceptual details were quantified as the number of unique objects in it (high‐load: > 4; low‐load: < 4). Results During encoding, PPA activity was higher for high‐load than low‐load scenes (P = 2.08e‐06) but did not differ between SCD and CON (P = .763), indicating comparable encoding of perceptual details across groups. Nevertheless, during retrieval, SCD appeared to benefit significantly less from perceptual details than CON (P = .018), as their false alarm rates were similar for high‐ and low‐load scenes (P = .879), whereas CON's were significantly lower for high‐load than low‐load scenes (P = .002). Conclusions Although tentative, our results suggest that SCD encode perceptual details similar to CON but use details to a lesser extent than CON when new information must be differentiated from old information during retrieval. Accordingly, memory complaints in SCD may reflect the perception of a 'lower‐resolution' retrieval, especially in the face of new information.

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Common and unique dysconnectivity profiles of dorsal and median raphe in Parkinson's disease

Wang

Sun

Gao

et al. 2022

Human Brain Mapping

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The serotonergic (5‐HT) system, which undergoes degeneration in Parkinson's disease (PD), is involved in the pathogenesis of motor and nonmotor symptoms. The dorsal raphe (DR) and median raphe (MR) nuclei are the main source of 5‐HT neurons, however, brain connectivity changes in these two nuclei have not been delineated in PD. Here we used resting‐state fMRI (rs‐fMRI) to characterize functional connectivity profiles of DR and MR and further examine the associations between dysconnectivity of raphe nuclei and clinical phenotypes of PD. We found that DR and MR commonly hypo‐connected with the sensorimotor, temporal, and occipital cortex, limbic system, left thalamus, putamen, and cerebellum in PD. DR had unique decreased connectivity with the bilateral prefrontal and cingulate cortices, while MR had lower connectivity with the pons. Moreover, reduced connectivity of DR correlated with depression, drowsiness, and anxiety, whereas dysconnectivity of MR correlated with depression, cognitive deficits, sleep disturbances, and pain. Our findings highlight the complex roles of raphe nuclei in motor and nonmotor symptoms, providing novel insights into the neurophysiological mechanisms underlying pathogenesis of PD.

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Direct brain recordings reveal occipital cortex involvement in memory development

Cited by 23 publications

References 62 publications

Dissociable oscillatory theta signatures of memory formation in the developing brain

Dissociable oscillatory theta signatures of memory formation in the developing brain

Lower‐resolution retrieval of scenes in older adults with subjective cognitive decline

Common and unique dysconnectivity profiles of dorsal and median raphe in Parkinson's disease

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