Direct capillary electrophoresis analysis of basic and acidic drugs from microliter volume of human body fluids after liquid-phase microextraction through nano-fibrous membrane

Román-Hidalgo, Cristina; Dvorak, M.W.; Kubáň, Pavel; Martín-Valero, María Jesús; Bello‐López, Miguel Ángel

doi:10.1007/s00216-019-02225-y

Cited by 13 publications

(2 citation statements)

References 29 publications

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“…Separation techniques such as HPLC, GC, and CE are widely used for quality control of samples with the presence of more than one analyte (single run analysis). These techniques were used for the quantification of ARG [6–8] and IBU [9–13] in the presence of other compounds. However, only one study was found showing the possibility of simultaneous determination of ARG and IBU [14].…”

Section: Introductionmentioning

confidence: 99%

Ultra‐rapid capillary zone electrophoresis method for simultaneous determination of arginine and ibuprofen

Prado

Ribeiro

Richter

2021

J of Separation Science

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The combination of arginine and ibuprofen is widely used for pain relief with a faster onset of action than conventional ibuprofen. Therefore, the determination of both compounds in a single run is highly desirable for rapid quality control applications. This paper reports an ultra‐fast method (100 injections/h) for simultaneous determination of arginine and ibuprofen using capillary electrophoresis with capacitively coupled contactless conductivity detection. The separation of arginine as cation and ibuprofen as anion was achieved using a background electrolyte composed by an equimolar mixture of 10 mmol/L of 2‐(cyclohexylamino) ethanesulfonic acid and boric acid with pH adjusted to 8.4 using potassium hydroxide. The limits of detections were 5.3 and 10.0 μmol/L for arginine and ibuprofen, respectively. The proposed method is simple, fast (one analysis every 35 s), environmentally friendly (minimal waste generation) and accurate (recovery values between 95 and 98%).

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Section: Introductionmentioning

confidence: 99%

Ultra‐rapid capillary zone electrophoresis method for simultaneous determination of arginine and ibuprofen

Prado

Ribeiro

Richter

2021

J of Separation Science

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“…Therefore, developing rapid, simple, and effective detection methods of naproxen is highly desirable. Traditional approaches for analysing the existence of naproxen include electrochemical techniques, 4,5 high performance liquid chromatography(HPLC), 6 flow injection analysis, 7 magnetic-solid phase extraction (M-SPE), 8 capillary electrophoresis (CE), 9 and absorption spectrophotometry. 10 These methods, however, demand specialized training, costly instruments, and complex sample preprocessing.…”

Section: Introductionmentioning

confidence: 99%

Highly sensitive and selective detection of naproxen via molecularly imprinted carbon dots as a fluorescent sensor

Zhang

et al. 2021

RSC Adv.

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Development of a 3D disposable device for the electrochemical determination of diclofenac in different matrices

et al. 2022

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Direct capillary electrophoresis analysis of basic and acidic drugs from microliter volume of human body fluids after liquid-phase microextraction through nano-fibrous membrane

Cited by 13 publications

References 29 publications

Ultra‐rapid capillary zone electrophoresis method for simultaneous determination of arginine and ibuprofen

Ultra‐rapid capillary zone electrophoresis method for simultaneous determination of arginine and ibuprofen

Highly sensitive and selective detection of naproxen via molecularly imprinted carbon dots as a fluorescent sensor

Development of a 3D disposable device for the electrochemical determination of diclofenac in different matrices

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