Direct comparison between negative wound pressure therapy and negatively charged polystyrene microspheres in wound bed preparation for split skin grafting in two large symmetric whole circumference leg ulcers, a single patient experience

Deluca, Jenny; Gatscher, Barbara; Tappeiner, Lukas; Pichler, Maria; Eisendle, Klaus

doi:10.1111/jdv.12527

Cited by 8 publications

(6 citation statements)

References 11 publications

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“…Ten articles were identified by handsearching the reference list of included studies. Finally, 102 17‐118 articles were included in this systematic review (Figure 1). The studies included were 53 case reports, 28 case series, 15 letters, and 6 conference abstracts published between 1930 and 2019.…”

Section: Resultsmentioning

confidence: 99%

Efficacy and safety of skin grafting in treatment of vasculitic ulcer and pyoderma gangrenosum—A systematic review

Morgenstjerne‐Schwenck

Knudsen

Prasad

2020

Wound Repair Regeneration

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Chronic painful ulcers caused by pyoderma gangrenosum (PG) and cutaneous vasculitis remain to be a therapeutic challenge. Skin grafts have been used with success in selected cases but are generally avoided due to the fear of pathergy. The aim of this study was to investigate the safety and efficacy of skin grafting in the treatment of primary vasculitic ulcer (PVU) and PG. MEDLINE, Embase, the Cochrane Library, http://clinicaltrial.gov, and WHO International Clinical Trials Registry Platform (ICTRP) were searched from inception to March 2020. A search for grey literature was conducted in May 2020. We included studies assessing the efficacy and safety of skin grafting in the treatment of PG and PVU. Studies were only included if skin grafting was performed after establishment of PG or PVU diagnosis. A total of 721 articles was identified through the database search of which 92 were included in this study. Ten articles were identified by handsearching the reference list of included studies. Finally, 102 articles describing 212 wounds in 153 patients were included. Complete healing was found in 75.5% of the wounds. The average time to complete was 10.8 weeks (95% CI 6.1‐15.6). The mean donor site healing time was 1.9 weeks (95% CI 0.52‐3.20). Pathergy was reported in 8 (5.2%) patients. One patient had severe infection related to skin grafting. A statistically significant difference in the number of patients receiving preoperative (P = .0079) and postoperative (P = .002) immunosuppressive therapy was found between the groups with complete healing/reduction and no improvement/aggravation. This systematic review finds the current evidence on efficacy and safety of skin grafting in treatment of PG and PVU to be promising but limited to the size and lack of studies superior to case reports and case series. Future placebo‐controlled trials are required to draw a stronger conclusion.

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Section: Resultsmentioning

confidence: 99%

Efficacy and safety of skin grafting in treatment of vasculitic ulcer and pyoderma gangrenosum—A systematic review

Morgenstjerne‐Schwenck

Knudsen

Prasad

2020

Wound Repair Regeneration

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“…According to our systematic review, few cases have a good evolution with the use of NPWT before starting immunosuppressive therapy or without association with immunosuppressive therapy. 8,15,[20][21][22][23][24][25][26][27] On the other hand, the absence of wound improvement after using the NPWT has also been described in the literature (Table 2). In most cases, this outcome occurred when NPWT was performed without association with systemic immunosuppressive therapy, which increases the likelihood of active disease, with an exacerbated inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

“…58 Other authors suggest that there is no reduction in wound pain or report pain when changing the dressing. 20,25,42,66 For pain relief change from the classic black polyurethane foam (V.A.C. GranuFoam) to the white alcohol polyvinyl foam (V.A.C.…”

Section: Discussionmentioning

confidence: 99%

“…It was analysed patients who had a successful healing outcome, comparing those who performed NPWT with a skin graft (n = 34)22,[25][26][27][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57] with those who performed NPWT alone (n = 13),20,21,24,33,44,[58][59][60][61][62][63][64][65] correlating with the healing time reported. 64.7% of patients who received NPWT with a skin graft (n = 22) had a healing time of less than or equal to 2 months, and 76.9% of patients who received NPWT alone (n = 10)…”

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confidence: 99%

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The role of negative pressure wound therapy (NPWT) on the treatment of pyoderma gangrenosum: A systematic review and personal experience

Almeida

Coltro

Gonçalves

et al. 2021

Wound Repair Regeneration

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Pyoderma gangrenosum (PG) is a rare painful ulcerative neutrophilic inflammatory skin disease, necessitating a high level of diagnostic suspicion associated with appropriate treatment to avoid progression. Negative pressure wound therapy (NPWT) has been efficiently used in the treatment of different types of wounds. However, the role of NPWT in the management of PG is still controversial, due to the risk of the pathergy phenomenon. In this article, we conducted a systematic review (according

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“…На результат свободной кожной пластики расщепленным трансплантатом влияют несколько факторов: кровоснабжение реципиентного ложа [4], техника выполнения операции, толщина кожного трансплантата [10], свойства местных лекарственных средств, входящих в состав повязки, накладываемой на рану [8,9]. Но одним из самых значимых факторов является микробный пейзаж хронической раны [7]. Особенностью таких ран, что и подтвердилось в нашем исследовании, является контаминация раневой поверхности антибиотикорезистентными штаммами микроорганизмов.…”

Section: оригинальное исследованиеunclassified

The results of monitoring the dynamics and antibiotic resistance of microflora when performing split-skin grafting in a general surgical hospital

Pavlenko¹,

Кичин²,

Бесчастнов³

2019

VECS

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Relevance. One of the effective ways to close chronic wounds according to many authors is split-skin grafting. To obtain good results of plastic operations, a constant monitoring of the structure of microbiological associations of chronic wounds and their sensitivity to antimicrobial agents is necessary. Aim. Analysis of the structure and properties of pathogens of wound infections when performing split-skin grafting and optimizing the choice of drugs for starting empirical antibacterial therapy. Materials and methods. A retrospective analysis of the results of microbiological studies was conducted in 86 patients who underwent split-skin grafting. For statistical processing of the data obtained, the computer program Statistica 6.0 was used. Results. Microbial contamination in patients on admission to hospital was (Me [Q1; Q3]) 106 [102; 108] CFU/ml. Unsatisfactory results of split-skin grafting were noted in 15 patients (17%). In this group of patients, strains of non-fermenting gram-negative bacteria - Pseudomonas aeruginosa (in 6 cases) and Acinetobacter baumannii (in 4 cases), which retained sensitivity to carbapenems in 65% of cases, were most often detected. Conclusions. Non-fermenting gram-negative microorganisms sharply reduce the likelihood of good results of plastic operations. If found in the recipient wound after split-skin grafting signs of an infectious process, it is advisable to use carbapenems.

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Direct comparison between negative wound pressure therapy and negatively charged polystyrene microspheres in wound bed preparation for split skin grafting in two large symmetric whole circumference leg ulcers, a single patient experience

Cited by 8 publications

References 11 publications

Efficacy and safety of skin grafting in treatment of vasculitic ulcer and pyoderma gangrenosum—A systematic review

Efficacy and safety of skin grafting in treatment of vasculitic ulcer and pyoderma gangrenosum—A systematic review

The role of negative pressure wound therapy (NPWT) on the treatment of pyoderma gangrenosum: A systematic review and personal experience

The results of monitoring the dynamics and antibiotic resistance of microflora when performing split-skin grafting in a general surgical hospital

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