Direct Condensation Reaction for Grafting of Polyethylene Glycol Monomethyl Ether on Poly(Methacrylic Acid-co-Methyl Methacrylate) for Application in Biomedical Engineering

Shirazi, Ali Negahi; Imani, Mohammad; Sharifi, Shahriar

doi:10.5923/j.ajbe.20110101.03

Cited by 4 publications

(4 citation statements)

References 44 publications

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“…For PEG grafting, pAAc−SFs were immersed in an aqueous solution containing 1:1 equivalent EDC and 5 mol % 4-(dimethylamino)phenol for 30 min. The films were then incubated with PEG for 6 h. 25 After completion of the reaction, the side products were washed three times with 70% methanol and finally rinsed with deionized (DI) water.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Controlling the Cell Adhesion Property of Silk Films by Graft Polymerization

Dhyani

Singh

2014

ACS Appl. Mater. Interfaces

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We report here a graft polymerization method to improve the cell adhesion property of Bombyx mori silk fibroin films. B. mori silk has evolved as a promising material for tissue engineering because of its biocompatibility and biodegradability. However, silk's hydrophobic character makes cell adhesion and proliferation difficult. Also, the lack of sufficient reactive amino acid residues makes biofunctionalization via chemical modification challenging. Our study describes a simple method that provides increased chemical handles for tuning of the surface chemistry of regenerated silk films (SFs), thus allowing manipulation of their bioactivity. By grafting pAAc and pHEMA via plasma etching, we have increased carboxylic acid and hydroxyl groups on silk, respectively. These modifications allowed us to tune the hydrophilicity of SFs and provide functional groups for bioconjugation. Our strategy also allowed us to develop silk-based surface coatings, where spatial control over cell adhesion can be achieved. This control over cell adhesion in a particular region of the SFs is difficult to obtain via existing methods of modifying the silk fibroin instead of the SF surface. Thus, our strategy will be a valuable addition to the toolkit of biofunctionalization for enhancing SFs' tissue engineering applications.

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Section: ■ Experimental Sectionmentioning

confidence: 99%

Controlling the Cell Adhesion Property of Silk Films by Graft Polymerization

Dhyani

Singh

2014

ACS Appl. Mater. Interfaces

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“…Alternative strategies leading to functionalized poly(methacrylates) include the condensation of poly(methacrylic acid) with alcohols in the presence of coupling agents, tandem catalysis of monomer transesterification and living radical polymerization, and utilization of polymeric active esters, such as poly(pentafluorophenyl methacrylate) . The drawbacks of these methods are the utilizations of costly reagents and the requirement of separate polymerization reactions for each desired material.…”

Section: Introductionmentioning

confidence: 99%

Direct access to functional (Meth)acrylate copolymers through transesterification with lithium alkoxides

Fleischmann

Anastasaki

Gutekunst

et al. 2017

J. Polym. Sci. Part A: Polym. Chem.

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A straightforward and efficient synthetic method that transforms poly(methyl methacrylate) (PMMA) into value-added materials is presented. Specifically, PMMA is modified by transesterification to produce a variety of functional copolymers from a single starting material. Key to the reaction is the use of lithium alkoxides, prepared by treatment of primary alcohols with LDA, to displace the methyl esters. Under optimized conditions, up to 65% functionalization was achieved and copolymers containing alkyl, alkene, alkyne, benzyl, and (poly)ether side groups could be prepared. The versatility of this protocol was further demonstrated through the functionalization of both PMMA homo and block copolymers obtained through either radical polymerization (traditional and controlled) or anionic procedures. The scope of this strategy was illustrated by extension to a range of architectures and polymer backbones.

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“…Instead we have chosen to inactivate tannins in vivo during the feeding and growth assays. PEG is known to form strong insoluble complexes with tannins and other poly acids resulting from the direct esterfication of hydroxyl and carboxyl functional groups (Makkar, 2003;Shirazi, Imani & Sharifi, 2011;Etuk et al, 2012).…”

Section: Experiments 3: Tannin Binding Experimentsmentioning

confidence: 99%

“…Besides its ability to bind tannins, PEG is highly biocompatible. Industry commonly utilizes PEG in medicine and agriculture because it is inert and has a low level of toxicity (Shirazi, Imani & Sharifi, 2011).…”

Section: Experiments 3: Tannin Binding Experimentsmentioning

confidence: 99%

Evidence that Treehoppers Induce Susceptibility of Oak Trees to Dietary Generalist Caterpillars

Comerford¹

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Lab group for helping me with field collections and colony care. Thanks to A. Agrawal for technical advice. Thanks to A. Burke and J. Coolon for being on the thesis committee and providing comments. A special thanks to M. Bernardo for helping me navigate the laboratory and to R. Clark for all the hours he spent guiding me through the statistics. Finally, my complete admiration and thanks to M. S. Singer for his guidance, support and unwavering patience over the past three years. Funding for this project came from Wesleyan University.

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Direct Condensation Reaction for Grafting of Polyethylene Glycol Monomethyl Ether on Poly(Methacrylic Acid-co-Methyl Methacrylate) for Application in Biomedical Engineering

Cited by 4 publications

References 44 publications

Controlling the Cell Adhesion Property of Silk Films by Graft Polymerization

Controlling the Cell Adhesion Property of Silk Films by Graft Polymerization

Direct access to functional (Meth)acrylate copolymers through transesterification with lithium alkoxides

Evidence that Treehoppers Induce Susceptibility of Oak Trees to Dietary Generalist Caterpillars

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