Direct coupling of supported liquid membranes to capillary electrophoresis for analysis of complex samples: A tutorial

Kubáň, Pavel; Boček, Petr

doi:10.1016/j.aca.2013.04.065

Cited by 31 publications

(7 citation statements)

References 67 publications

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“…Among the readily available detection techniques, HPLC is of specific interest for the analysis of antibiotics because of its sensitivity and user-friendliness. It is a challenge to determine these trace contaminants directly as they exist in complex matrices, which necessitates the use of preconcentration methods [13]. To eliminate the matrix effect, various preconcentration methods have been routinely employed, including liquid-liquid extraction (LLE) [14], dispersive liquid-liquid extraction (DLLME) [15], dispersive solid-phase extraction (DSPE) [16], and the most commonly used, solid-phase extraction (SPE).…”

Section: Introductionmentioning

confidence: 99%

Application of activated carbon-decorated polyacrylonitrile nanofibers as an adsorbent in dispersive solid-phase extraction of fluoroquinolones from wastewater

Dimpe

Nomngongo

2019

Journal of Pharmaceutical Analysis

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A cheap and simple sample preparation method, consisting of a dispersive solid-phase method and an adsorbent, activated carbon decorated PAN nanofibers, was employed and used for the extraction of antibiotics (ciprofloxacin, danofloxacin, and enrofloxacin) in wastewater. Electrospun PAN nanofibers that were decorated with activated carbon produced from waste tires were used as the solid phase and the antibiotics analyzed by using high-performance liquid chromatography. Parameters such as pH, mass of adsorbent (MA), extraction volume (EV), and extraction time (ET) were optimized owing to their potential effect on the extraction of antibiotics from water. The recovery of all antibiotics was satisfactory, in the range of 90%–99%. The limits of detection and quantification were 0.05, 0.11, 0.20, and 0.53, 1.21, 2.17 µg/L, respectively. The precision was determined from the repeatability and reproducibility and expressed as the intra-day ( n = 20) and inter-day ( n = 5) precision. The intra-day and inter-day precision was reported in terms of the percentage relative standard deviation, which was 3% and 4%, respectively. The adsorption capacity of the activated carbon-decorated PAN nanofibers was satisfactory, and the reusability of the adsorbent was impressive when reused ten times. The accuracy of the dispersive solid phase extraction (DSPE) was validated by spike recovery tests; the results proved the reliability and efficiency of adsorbing antibiotics from wastewater. Finally, the proposed method was applied to wastewater samples collected from a wastewater treatment plant, which included influent, secondary, and effluent wastewater.

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Section: Introductionmentioning

confidence: 99%

Application of activated carbon-decorated polyacrylonitrile nanofibers as an adsorbent in dispersive solid-phase extraction of fluoroquinolones from wastewater

Dimpe

Nomngongo

2019

Journal of Pharmaceutical Analysis

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“…In subsequent experiments, extraction characteristics of PA6 membrane were compared to PP membrane, which has been typically used for in‐line coupling of SLM extractions to CE . Nortriptyline, haloperidol, loperamide and papaverine were selected as model basic drugs, which cover wide range of pK a and log P values (https://www.drugbank.ca/drugs, 16 th November 2018).…”

Section: Resultsmentioning

confidence: 99%

“…For non‐agitated SLM‐CE system, stable concentrations of transferred analytes are achieved faster at the membrane surface rather than in the entire acceptor solution and analytes were injected hydrodynamically directly from the SLM. Capillary injection end was inserted into acceptor unit (the top part) of the microextraction device and gently contacted the SLM surface.…”

Section: Methodsmentioning

confidence: 99%

In‐line coupling of supported liquid membrane extraction across nanofibrous membrane to capillary electrophoresis for analysis of basic drugs from undiluted body fluids

Dvorak

Kubáň

2019

Electrophoresis

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Planar polyamide 6 nanofibrous membrane was for the first time used in direct coupling of supported liquid membrane (SLM) extraction to CE analysis. Disposable microextraction device with the nanofibrous membrane was preassembled and stored for immediate use. The membrane in the device was impregnated with 1 µL of 1‐ethyl‐2‐nitrobenzene and the device was subsequently filled with 10 µL of acceptor solution (10 mM HCl) and 15 µL of donor solution (sample). The device was in‐line coupled to CE system for selective extraction and direct injection, separation and quantification of model basic drugs (nortriptyline, haloperidol, loperamide and papaverine) from standard saline solutions (150 mM NaCl) and from undiluted human body fluids (urine and blood plasma). Compared to standard polypropylene supporting material, the nanofibrous membrane demonstrated superior characteristics in terms of lower consumption of organic solvents, constant volumes of operational solutions, full transparency and possibility to preassemble the devices. Extraction parameters were better or comparable for the nanofibrous vs. the polypropylene membrane and the hyphenated SLM‐CE method with the nanofibrous membrane was characterized by good repeatability (RSD ≤ 11.3%), linearity (r2 ≥ 0.9953; 0.5–20 mg/L), sensitivity (LOD ≤ 0.4 mg/L) and transfer (27–126%) of the basic drugs.

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“…The SLM consists of a porous polymeric material, which is impregnated with a water‐immiscible organic solvent and adopted as a selective barrier between two aqueous solutions. Recently, Kubáň and Boček published a detailed overview on the practicability of direct coupling of flat sheet based SLMs to CE, covering fundamental and instrumental aspects. Pantůčková and co‐workers proposed a simple device that enables direct in‐line coupling of SLM extraction to a commercial CE system for rapid determination of selected basic drugs spiked in human urine and serum.…”

Section: Extractionmentioning

confidence: 99%

Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2012–2014)

et al. 2015

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One of the most cited limitations of capillary (and microchip) electrophoresis is the poor sensitivity. This review continues to update this series of biannual reviews, first published in Electrophoresis in 2007, on developments in the field of on-line/in-line concentration methods, covering the period July 2012-July 2014. It includes developments in the field of stacking, covering all methods from field-amplified sample stacking and large-volume sample stacking, through to ITP, dynamic pH junction, and sweeping. Attention is also given to on-line or in-line extraction methods that have been used for electrophoresis.

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Direct coupling of supported liquid membranes to capillary electrophoresis for analysis of complex samples: A tutorial

Cited by 31 publications

References 67 publications

Application of activated carbon-decorated polyacrylonitrile nanofibers as an adsorbent in dispersive solid-phase extraction of fluoroquinolones from wastewater

Application of activated carbon-decorated polyacrylonitrile nanofibers as an adsorbent in dispersive solid-phase extraction of fluoroquinolones from wastewater

In‐line coupling of supported liquid membrane extraction across nanofibrous membrane to capillary electrophoresis for analysis of basic drugs from undiluted body fluids

Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2012–2014)

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