Direct detection of whole bacteria using a nonlinear acoustic resonator

Khobragade, Shilpa; Granja, Carlos da Silva; Sandström, Niklas; Efimov, Igor; Ostanin, Victor P.; Wijngaart, Wouter van der; Klenerman, David; Ghosh, Sourav

doi:10.1016/j.snb.2020.128086

Cited by 7 publications

(3 citation statements)

References 23 publications

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“…A custom-built network analyser with PC-based graphical user interface control and a facility to drive at a wide range of frequency and amplitude was employed for actuating and sensing the QCR [105,108]. Wolfram Mathematica 10 was used for processing the experimental data.…”

Section: Experimental Set-upmentioning

confidence: 99%

Simpler and faster quartz crystal microbalance for macromolecule detection using fixed frequency drive

Guha

Sandström

Ostanin

et al. 2022

Sensors and Actuators B: Chemical

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Section: Experimental Set-upmentioning

confidence: 99%

Simpler and faster quartz crystal microbalance for macromolecule detection using fixed frequency drive

Guha

Sandström

Ostanin

et al. 2022

Sensors and Actuators B: Chemical

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“…The sensitive detection of bacteria is of vital importance for early diagnosis and treatment of bacteria-induced diseases. Compared to traditional methods, microfluidics technology can achieve rapid and efficient detection, by integrating functional components and various detection approaches including optical, electrical-based, or acoustic-based sensing methods. − …”

Section: Microfluidics-based Analysis Of Biospeciesmentioning

confidence: 99%

Microfluidics-Based Sensing of Biospecies

Xing

Zhao

Cheng

et al. 2020

ACS Appl. Bio Mater.

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Over the past decades, microfluidic devices based on many advanced techniques have aroused widespread attention in the fields of chemical, biological, and analytical applications. Integration of microdevices with a variety of chip designs will facilitate promising functionality. Notably, the combination of microfluidics with functional nanomaterials may provide creative ideas to achieve rapid and sensitive detection of various biospecies. In this review, focused on the microfluids and microdevices in terms of their fabrication, integration, and functions, we summarize the up-to-date developments in microfluidics-based analysis of biospecies, where biomarkers, small molecules, cells, and pathogens as representative biospecies have been explored in-depth. The promising applications of microfluidic biosensors including clinical diagnosis, food safety control, and environmental monitoring are also discussed. This review aims to highlight the importance of microfluidics-based biosensors in achieving high throughput, highly sensitive, and low-cost analysis and to promote microfluidics toward a wider range of applications.

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“…Yu et al [13] reported a LOD of 1.46 × 10 3 CFU/ mL for E. coli O157:H7 detection by QCM. Most recently, Khobragade et al [19] achieved a LOD of 10 4 CFU/mL for E. coli using aptasensors based on a non-linear quartz crystal resonator method (QCR).…”

Section: Introductionmentioning

confidence: 99%

Detection of E. coli Bacteria in Milk by an Acoustic Wave Aptasensor with an Anti-Fouling Coating

Spagnolo

Franier

Davoudian

et al. 2022

Sensors

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Milk is a significant foodstuff around the world, being produced and consumed in large quantities. The safe consumption of milk requires that the liquid has an acceptably low level of microbial contamination and has not been subjected to spoiling. Bacterial safety limits in milk vary by country but are typically in the thousands per mL of sample. To rapidly determine if samples contain an unsafe level of bacteria, an aptamer-based sensor specific to Escherichia coli bacteria was developed. The sensor is based on an ultra-high frequency electromagnetic piezoelectric acoustic sensor device (EMPAS), with the aptamer being covalently bound to the sensor surface by the anti-fouling linker, MEG-Cl. The sensor is capable of the selective measurement of E. coli in PBS and in cow’s milk samples down to limits of detection of 35 and 8 CFU/mL, respectively, which is well below the safe limits for commercial milk products. This sensing system shows great promise for the milk industry for the purpose of rapid verification of product safety.

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Direct detection of whole bacteria using a nonlinear acoustic resonator

Cited by 7 publications

References 23 publications

Simpler and faster quartz crystal microbalance for macromolecule detection using fixed frequency drive

Simpler and faster quartz crystal microbalance for macromolecule detection using fixed frequency drive

Microfluidics-Based Sensing of Biospecies

Detection of E. coli Bacteria in Milk by an Acoustic Wave Aptasensor with an Anti-Fouling Coating

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