2011
DOI: 10.1103/physrevlett.107.088102
|View full text |Cite
|
Sign up to set email alerts
|

Direct Determination of the Base-Pair Force Constant of DNA from the Acoustic Phonon Dispersion of the Double Helix

Abstract: Quantifying the molecular elasticity of DNA is fundamental to our understanding of its biological functions. Recently different groups, through experiments on tailored DNA samples and numerical models, have reported a range of stretching force constants (0.3 to 3 N=m). However, the most direct, microscopic measurement of DNA stiffness is obtained from the dispersion of its vibrations. A new neutron scattering spectrometer and aligned, wet spun samples have enabled such measurements, which provide the first dat… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

2
16
0

Year Published

2012
2012
2023
2023

Publication Types

Select...
7
2

Relationship

1
8

Authors

Journals

citations
Cited by 27 publications
(18 citation statements)
references
References 26 publications
2
16
0
Order By: Relevance
“…These apparent discrepancies between macroscopic and microscopic flexibilities are not unexpected. Even for DNA, it has been difficult to reconcile microscopic flexibility with mesoscopic persistence length measurements (9,10). …”
Section: Introductionmentioning
confidence: 99%
“…These apparent discrepancies between macroscopic and microscopic flexibilities are not unexpected. Even for DNA, it has been difficult to reconcile microscopic flexibility with mesoscopic persistence length measurements (9,10). …”
Section: Introductionmentioning
confidence: 99%
“…This interest exceeds the domain of physics and extends to biological structures such as DNA. 5,6 However, none of the existing 1D systems was stable at high temperature. This is why the discovery of single-walled carbon nanotube (SWNT) inclusion compounds has once again highlighted 1D systems and their particular thermodynamics.…”
Section: Introductionmentioning
confidence: 99%
“…The dynamical structure factor of such a system can be 396 C. Bousige et al calculated exactly (8)(9)(10). Inelastic neutron scattering (INS) experiments were successfully performed with Hg 3-δ AsF 6 single crystals where long 1D mercury chains were shown to be 1D harmonic liquid above the critical temperature of 120 K (11), and the same type of study was also performed on water chains in DNA (12,13). Nevertheless, the common problem of these compounds is that they are not stable at high temperature, and that when lowering the temperature a long range order establishes due to the interaction with the three-dimensional (3D) network (14)(15)(16), preventing one from studying 1D properties on a wide temperature range.…”
Section: Introductionmentioning
confidence: 88%