Direct Effects of poly(ε-caprolactone) lipid-core Nanocapsules on Human Immune Cells

Sandri, Silvana; Hebeda, Cristina Bichels; Loiola, Rodrigo Azevedo; Calgaroto, Selma; Uchiyama, Mayara Klimuk; Araki, Koji; Frank, Luíza Abrahão; Paese, Karina; Guterres, Sílvia Stanisçuaski; Pohlmann, Adriana Raffin; Farsky, Sandra Helena Poliselli

doi:10.2217/nnm-2018-0484

Cited by 13 publications

(10 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another interesting study looked at the direct effects of drug-free poly(ε-caprolactone) lipid-core nanocapsules (LNCs) on leukocytes and found that these particles inhibit the secretory abilities of leukocytes in both basal and stimulated conditions. This suggest that even carrier particles can have distinct effects on leukocyte function and must be carefully evaluated and then used to guide their therapeutic applications to avoid discrepancies between the immunological effects of the carrier and the drug itself [99].…”

Section: Leukocyte Function In Hemostasis and The Mechanisms Involmentioning

confidence: 99%

The Hemocompatibility of Nanoparticles: A Review of Cell–Nanoparticle Interactions and Hemostasis

Harpe

Kondiah

Choonara

et al. 2019

Cells

250

143

View full text Add to dashboard Cite

Understanding cell–nanoparticle interactions is critical to developing effective nanosized drug delivery systems. Nanoparticles have already advanced the treatment of several challenging conditions including cancer and human immunodeficiency virus (HIV), yet still hold the potential to improve drug delivery to elusive target sites. Even though most nanoparticles will encounter blood at a certain stage of their transport through the body, the interactions between nanoparticles and blood cells is still poorly understood and the importance of evaluating nanoparticle hemocompatibility is vastly understated. In contrast to most review articles that look at the interference of nanoparticles with the intricate coagulation cascade, this review will explore nanoparticle hemocompatibility from a cellular angle. The most important functions of the three cellular components of blood, namely erythrocytes, platelets and leukocytes, in hemostasis are highlighted. The potential deleterious effects that nanoparticles can have on these cells are discussed and insight is provided into some of the complex mechanisms involved in nanoparticle–blood cell interactions. Throughout the review, emphasis is placed on the importance of undertaking thorough, all-inclusive hemocompatibility studies on newly engineered nanoparticles to facilitate their translation into clinical application.

show abstract

Section: Leukocyte Function In Hemostasis and The Mechanisms Involmentioning

confidence: 99%

The Hemocompatibility of Nanoparticles: A Review of Cell–Nanoparticle Interactions and Hemostasis

Harpe

Kondiah

Choonara

et al. 2019

Cells

250

143

View full text Add to dashboard Cite

show abstract

“…For instance, lipid‐core nanocapsules (LCNs) decrease cells migration rate, IL‐8 production, intracellular Ca 2+ level, and phosphorylation of p38 and ERK1/2. [ 142 ] Certain types of NPs, such as liposomes and PS NPs, neither stimulate nor inhibit NΦ functions and viability. [ 143 ]…”

Section: Nanoparticles‐induced Neutrophil Responses: the Safety Concerns Of Cell‐based Shippingmentioning

confidence: 99%

“…For instance, lipid-core nanocapsules (LCNs) decrease cells migration rate, IL-8 production, intracellular Ca 2+ level, and phosphorylation of p38 and ERK1/2. [142] Certain types of NPs, such as liposomes and PS NPs, neither stimulate nor inhibit NΦ functions and viability. [143] Based on the available data on NP-NΦ interaction it is problematic to find the correlation between any one single parameter of NP and cell response.…”

Section: Nanoparticles-induced Neutrophil Responses: the Safety Concerns Of Cell-based Shippingmentioning

confidence: 99%

See 1 more Smart Citation

Neutrophil and Nanoparticles Delivery to Tumor: Is It Going to Carry That Weight?

Vishnevskiy

Garanina

Chernysheva

et al. 2021

Adv Healthcare Materials

View full text Add to dashboard Cite

The application of cell carriers for transporting nanodrugs to the tumor draws much attention as the alternative to the passive drug delivery. In this concept, the neutrophil (NΦ) is of special interest as this cell is able to uptake nanoparticles (NPs) and cross the vascular barrier in response to tumor signaling. There is a growing body of literature describing NP–NΦ interactions in vitro and in vivo that demonstrates the opportunity of using these cells to improve the efficacy of cancer therapy. However, a number of conceptual and technical issues need to be resolved for translating the technology into clinics. The current review summarizes the recent advances and challenges associated with NP–NΦ interactions, with the special focus on the complex interplay between the NP internalization pathways and the modulation of NΦ activity, and its potential consequences for nanodrug delivery.

show abstract

“…Different types of nanomaterials have been used as targeted carriers, including poly(ε-caprolactone) (PCL) lipid-core nanocapsules (LNCs) [ 20 ]. PCL-LNCs, which are composed of an oil nucleus revested by a PCL polymeric schedule, have a high encapsulation capacity of lipophilic substances and are considered a promising device in drug delivery [ 21 , 22 ]. The use of PCL as a polymer is appropriate once it presents biodegradability and biocompatibility capacity, which makes it an up-and-coming drug carrier with high potential for therapeutic applications [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice

et al. 2021

Self Cite

View full text Add to dashboard Cite

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are inflammatory and oxidative imbalance lung conditions with no successful pharmacological therapy and a high mortality rate. Resveratrol (RSV) is a plant-derived stilbene that presents anti-inflammatory and antioxidant effects. However, its therapeutic application remains limited due to its poor bioavailability, which can be solved by the use of nanocarriers. Previously, we demonstrated that nanoencapsulated RSV (RSV-LNC) pre-treatment, performed 4 h before lipopolysaccharide (LPS) stimulation in mice, increased its anti-inflammatory properties. In this study, we evaluated the anti-inflammatory and antioxidant effects, and lung distribution of RSV-LNCs administered therapeutically (6 h post LPS exposure) in a lung injury mouse model. The results showed that RSV-LNCs posttreatment improved lung function and diminished pulmonary inflammation. Moreover, RSV-LNC treatment enhanced the antioxidant catalase level together with a decrease in the oxidative biomarker in mouse lungs, which was accompanied by an increase in pulmonary Nrf2 antioxidant expression. Finally, the presence of RSV in lung tissue was significantly detected when mice received RSV-LNCs but not when they received RSV in its free form. Together, our results confirm that RSV nanoencapsulation promotes an increase in RSV bioavailability, enhancing its therapeutic effects in an LPS-induced lung injury model.

show abstract

Direct Effects of poly(ε-caprolactone) lipid-core Nanocapsules on Human Immune Cells

Cited by 13 publications

References 52 publications

The Hemocompatibility of Nanoparticles: A Review of Cell–Nanoparticle Interactions and Hemostasis

The Hemocompatibility of Nanoparticles: A Review of Cell–Nanoparticle Interactions and Hemostasis

Neutrophil and Nanoparticles Delivery to Tumor: Is It Going to Carry That Weight?

Resveratrol-Loaded Lipid-Core Nanocapsules Modulate Acute Lung Inflammation and Oxidative Imbalance Induced by LPS in Mice

Contact Info

Product

Resources

About