Direct effects of potassium on renin secretion and renal function

Vander, AJ

doi:10.1152/ajplegacy.1970.219.2.455

Cited by 161 publications

(58 citation statements)

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“…The only persistent abnormality which could be plasma aldosterone was observed. observed in our patients was hypokalemia, which is known to Blood sodium and potassium remained unchanged during A I1 induce high PRA levels (6,26). Therefore, we strongly support the infusion.…”

Section: Sodium Restrictionsupporting

confidence: 77%

Effect of Sodium Restriction and Angiotensin II Infusion in Bartter's Syndrome

et al. 1976

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Section: Sodium Restrictionsupporting

confidence: 77%

Effect of Sodium Restriction and Angiotensin II Infusion in Bartter's Syndrome

et al. 1976

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“…This suppressing effect of potassium could be an indirect consequence of potassium stimulation of aldosterone secretion or a more direct effect of potassium on renal renin secretion. The latter mechanism is supported by two reports which describe an acute reduction of plasma renin in dogs given potassium infusions (15,16).…”

mentioning

confidence: 66%

The influence of potassium administration and of potassium deprivation on plasma renin in normal and hypertensive subjects

Brunner¹,

Baer²,

Sealey³

et al. 1970

J. Clin. Invest.

223

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A B S T R A C T The effect of potassium administration and of dietary potassium deprivation on plasma renin activity and aldosterone excretion has been studied in 10 normal subjects and in 12 hypertensive patients maintained on a constant dietary regimen.Potassium administration reduced plasma renin activity in 18 of 28 studies of both normal and hypertensive subjects. Suppression of renin often occurred despite sodium diuresis induced by potassium administration. The renin suppression was related to induced changes in plasma potassium concentration and urinary potassium excretion.The failure of suppression of plasma renin in 10 studies could be accounted for by the smaller amounts of potassium administered to these subjects, together with a possibly overriding influence of an induced sodium diuresis.In six studies potassium deprivation invariably increased plasma renin activity even though a tendency for sodium retention often accompanied this procedure.The data indicate that both the suppression of plasma renin activity induced by potassium administration and the stimulation of renin activity which follows potassium depletion occur independently of associated changes in either aldosterone secretion or in sodium balance. However, the results do suggest that in various situations, the influence of potassium on plasma renin activity may be either amplified or preempted by changes in sodium balance.These interactions between potassium and plasma renin could be mediated by an ill-defined extrarenal pathway. But the findings are more consistent with an

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“…In this study, aldosterone was not responsible since its concentration decreased despite the marked increase in plasma renin activity. The latter may be a direct /2 effect (Vander, 1970, Salvetti, Poli, Arzille, Sassano, Pedrinelli & Motelesem, 1978 or may be mediated by hypokalaemia (Vander, 1970). The lack of electrocardiographic changes attributable to hypokalaemia may be explained by the normal cell potassium content (Surawicz, 1967).…”

Section: Methodsmentioning

confidence: 99%

Metabolic and cardiovascular side effects of the beta 2‐adrenoceptor agonists salbutamol and rimiterol.

Phillips¹,

Vedig²,

Jones³

et al. 1980

Brit J Clinical Pharma

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The metabolic and cardiovascular side‐effects of intravenous infusions of therapeutic doses of beta 2‐adrenoceptor agonists salbutamol and rimiterol have been determined in four healthy male subjects. There were dose‐related increases in plasma glucose, renin activity, serum insulin and heart rate, and significant hyperlactataemia and ketonaemia. There were dose‐related decreases in plasma potassium, phosphate and corticosteroids and significant hypocalcaemia and hypomagnesaemia. The effects of equivalent molar amounts of salbutamol and rimiterol were similar. Whichever drug is used, special care is required with patients who may have abnormal glucose tolerance, potassium depletion, or be predisposed to lactic acidosis. Rimiterol may be preferable for infusion because of its short plasma half‐life.

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Direct effects of potassium on renin secretion and renal function

Cited by 161 publications

References 0 publications

Effect of Sodium Restriction and Angiotensin II Infusion in Bartter's Syndrome

Effect of Sodium Restriction and Angiotensin II Infusion in Bartter's Syndrome

The influence of potassium administration and of potassium deprivation on plasma renin in normal and hypertensive subjects

Metabolic and cardiovascular side effects of the beta 2‐adrenoceptor agonists salbutamol and rimiterol.

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