2003
DOI: 10.1161/01.cir.0000088784.25089.d9
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Direct Imaging of Exercise-Induced Myocardial Ischemia With Fluorine-18–Labeled Deoxyglucose and Tc-99m-Sestamibi in Coronary Artery Disease

Abstract: Background-Scintigraphic myocardial perfusion imaging is the most widely used noninvasive modality for the detection of coronary artery disease (CAD). A technique for direct imaging of exercise-induced myocardial ischemia is highly desirable and preferable over perfusion imaging but is presently unavailable. We evaluated the feasibility and diagnostic accuracy of direct imaging of exercise-induced myocardial ischemia with fluorine-18-2-deoxyglucose ( 18 FDG). Methods and Results-Twenty-six patients with known … Show more

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Cited by 89 publications
(80 citation statements)
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“…18 FDG, a radiolabeled glucose analogue has been evaluated is several relatively small experimental animal as well as clinical studies as a potential myocardial ischemia imaging agent with highly encouraging results. [20][21][22][23][24][25][26][27][28][29][30][31][32] Although earlier studies indicated its feasibility, the clinical potential of this technique was appreciated only after it was possible to precisely localize any observed or perceived increased 18 FDG uptake to the myocardium either by simultaneous perfusion and 18 FDG imaging using PET imaging capable gamma cameras or by PET-CT imaging. 24,28 In this issue of the journal Sasikumar et al have presented their preliminary data on successful use of 18 FDG PET-CT for imaging of exercise-induced myocardial ischemia.…”
mentioning
confidence: 99%
“…18 FDG, a radiolabeled glucose analogue has been evaluated is several relatively small experimental animal as well as clinical studies as a potential myocardial ischemia imaging agent with highly encouraging results. [20][21][22][23][24][25][26][27][28][29][30][31][32] Although earlier studies indicated its feasibility, the clinical potential of this technique was appreciated only after it was possible to precisely localize any observed or perceived increased 18 FDG uptake to the myocardium either by simultaneous perfusion and 18 FDG imaging using PET imaging capable gamma cameras or by PET-CT imaging. 24,28 In this issue of the journal Sasikumar et al have presented their preliminary data on successful use of 18 FDG PET-CT for imaging of exercise-induced myocardial ischemia.…”
mentioning
confidence: 99%
“…Our group has recently shown that 18 F-FDG injected at peak exercise under fasting conditions is taken up selectively by the ischemic myocardium and this can be used as a hot spot imaging agent for the detection of CAD in clinical practice. [5][6][7][8] Under fasting conditions (particularly after fasting for over 12 hours), normal myocardium has very little myocardial 18 F-FDG uptake due to low blood sugar and insulin levels. However, myocardial ischemia results in a profound increase in regional glucose and 18 F-FDG uptake, which is not dependent upon blood glucose and insulin levels.…”
Section: See Related Article Pp 763-768mentioning
confidence: 99%
“…This is consistent with our clinical studies, where 18 F-FDG uptake following its injection at peak exercise in patients with coronary artery disease fasted for C12 hours was seen only in ischemic myocardium. [6][7][8] Yu et al studied only resting myocardial uptake of 18 F-BMS-747158-02 and 18 F-FDG in normal rats under different physiological studies. It would have been very helpful had the authors also included a parallel group of animals, who were given a catecholamine agent under fasting or fed conditions just before the administration of 18 F-BMS747158-02 or 18 F-FDG to mimic the effect of exercise to determine the differences between 18 F-BMS747158-02 and 18 F-FDG myocardial uptake at rest and on pharmacological stress.…”
Section: See Related Article Pp 763-768mentioning
confidence: 99%
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“…One technique, dual-isotope imaging, traces two different radiopharmaceuticals (a positron emitter and a gamma emitter) under the same experimental conditions [6][7][8]. We have developed a pinhole collimator suitable for small animal imaging in such studies.…”
Section: Introductionmentioning
confidence: 99%